Results 271 to 280 of about 420,437 (312)

Protease‐Activated Plasmonic Nanosensors for Predictive Ultrasound‐Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy

Advanced Science, EarlyView.
Protease‐activated plasmonic nanosensors are demonstrated to noninvasively monitor antitumor T cell activity in tumors with anatomical information upon adoptive T cell transfer via ultrasound‐guided photoacoustic imaging. These nanosensors are actuated by granzyme B, a protease secreted by activated cytotoxic T cells during tumor cell killing, which ...
Myeongsoo Kim, Seoyoon Song, Ali Zamat, Paul S. Pelkowski, Shivashankar Subramanian, Melissa Cadena, Sydney Fabrega, Meredith Brienen, Jinhwan Kim, Gabriel A. Kwong, Stanislav Y. Emelianov   +10 more
wiley   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

Advanced Science, EarlyView.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li, Yun Li, Yating Hu, Yanbing Yao, Yaodong He, Jing Li, Jiaqi Tang, Zhenyan Zhao, Yan Wang, Yulun He, Xiaolong Zhang, Xinjie Yang, Jianhua Wei   +12 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Promising immunotherapy: Highlighting cytokine‐induced killer cells

Journal of Cellular Biochemistry, 2018
For many years, cancer therapy has appeared to be a challenging issue for researchers and physicians. By the introduction of novel methods in immunotherapy, the prospect of cancer therapy even more explained than before.
Solmaz Shirjang, Nazila Alizadeh, B. Mansoori, A. Mahmoodpoor, Hossein Samadi Kafil, M. Hojjat-Farsangi, M. Yousefi   +6 more
semanticscholar   +3 more sources

Dendritic-cell-activated-cytokine-induced-killer-cells

Reactions Weekly

semanticscholar   +2 more sources

A Single-Chain Variable Fragment Antibody/Chemokine Fusion Protein Targeting Human Endoglin to Enhance the Anti-Tumor Activity of Cytokine-Induced Killer Cells.

Journal of Biomedical Nanotechnology, 2021
Cytokine-induced killer cell immunotherapy is an ideal candidate for adoptive cell transfer therapy. However, therapeutic approaches to enhance the anti-tumor activity of cytokine-induced killer cells remain to be explored.
Xuandong Lin, Haixia Li, Xi Li, Xiao-mei Yang, Wei Shi, Ziqiang Ding, Dani Zhong, Yangzi Li, Wenli Yang, Xia Yu, Shenxia Xie, Xiaobing Jiang, Xiaoling Lu   +12 more
semanticscholar   +1 more source

Cancer Immunotherapy with Cytokine-Induced Killer Cells

Targeted Oncology, 2017
Cytokine-induced killer (CIK) cells form under certain stimulation conditions in cultures of peripheral blood mononuclear cells (PBMCs). They are a heterogeneous immune cell population and contain a high percentage of cells with a mixed T-NK phenotype (CD3+CD56+).
J. J. Mata-Molanes, M. Sureda González, B. Valenzuela Jiménez, Elena Mª Martínez Navarro, A. Brugarolas Masllorens   +4 more
semanticscholar   +3 more sources

Activated T cells and cytokine-induced CD3 + CD56 + killer cells

Annals of Hematology, 1997
Over the past two decades, attempts have been made to develop immunotherapy for patients with cancer. A significant obstacle to the development of successful adoptive immunotherapy has been the availability of appropriate cytotoxic cells. Immunologic effector cells such as lymphokine-activated killer (LAK) cells, activated T cells such as tumor ...
G D, Schmidt-Wolf, R S, Negrin, I G, Schmidt-Wolf   +2 more
openaire   +2 more sources