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Is there a Role for Cytokine-Induced Killer Cells in Cancer Immunotherapy?
Immunotherapy, 2012867 ISSN 1750-743X 10.2217/IMT.12.89 © 2012 Future Medicine Ltd Immunotherapy (2012) 4(9), 867–869 “There is no doubt that the use of cytokine-induced killer cells holds promise but only the future will tell us whether this relatively simple form of adoptive cellular immunotherapy will really have an impact on the still dismal prognosis of patients ...
Rutella, Sergio, Locatelli, Franco
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Promising immunotherapy: Highlighting cytokine‐induced killer cells
Journal of Cellular Biochemistry, 2018AbstractFor many years, cancer therapy has appeared to be a challenging issue for researchers and physicians. By the introduction of novel methods in immunotherapy, the prospect of cancer therapy even more explained than before. Cytokine‐induced killer (CIK) cell‐based immunotherapy demonstrated to have potentiality in improving clinical outcomes and ...
Solmaz Shirjang +6 more
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Activated T cells and cytokine-induced CD3 + CD56 + killer cells
Annals of Hematology, 1997Over the past two decades, attempts have been made to develop immunotherapy for patients with cancer. A significant obstacle to the development of successful adoptive immunotherapy has been the availability of appropriate cytotoxic cells. Immunologic effector cells such as lymphokine-activated killer (LAK) cells, activated T cells such as tumor ...
R S Negrin, Ingo G H Schmidt-Wolf
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Cytokine Induced Killer (CIK) cells for the treatment of haematological neoplasms
Immunology Letters, 2013Cytokine Induced Killer (CIK) cells are in vitro activated human CD8 T cells which have maintained several characteristics of T-EMRA cells and additionally acquired non specific anti tumoral cytotoxicity and CD56 overexpression, thus representing a cell population with double T and NK phenotype.
Martino Introna +2 more
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Immunotherapy with Cytokine-Induced Killer Cells in Metastatic Renal Cell Carcinoma
Cancer Biotherapy and Radiopharmaceuticals, 2010Cytokine-induced killer (CIK) cells have shown antitumor activity against several tumor cells both in vitro and in vivo. This study reports on the large-scale expansion of CIK cells and also present preliminary results from a pilot clinical trial.
Xiaosan, Su +6 more
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Clinical expansion of cytokine induced killer (CIK) cells
ISBT Science Series, 2012Cytokine induced killer (CIK) cells are polyclonal T cells that can be expanded from marrow or peripheral blood lymphocytes with potent non‐MHC‐restricted cytotoxicity against a variety of tumor target cells. Earlier work had established the superiority of CIK cells over LAK cells in terms expansion and cytotoxicity.
M. B. C. Koh, Y. Ching Linn
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Ultrastructure of cytokine induced human natural killer cells
Cytotherapy, 2019Background & Aim Natural Killer (NK) cells account for 3.66-26.74% of lymphocytes in the human peripheral blood. They secrete exosomes which express both NK-cell markers and cytokines. It has been shown that Interkin-2 (IL-2) stimulated the proliferation of natural killer cells, a sub-class of lymphocytes in human.
W. Ng, D. Tam, D. Liao, W. Lee, F. Chan
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Inhibition of human ovarian tumor growth by cytokine-induced killer cells
Archives of Pharmacal Research, 2007Despite the recent improvement in the treatment of ovarian cancer, this disease is still leading cause of cancer death in women. In this study, the anti-tumor activity of cytokine-induced killer (CIK) cells against human ovarian cancer was evaluated in vitro and in vivo.
Hwan Mook, Kim +12 more
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Cytokine-induced Killer Cells: NK-like T Cells with Cytotolytic Specificity against Leukemia
Leukemia and Lymphoma, 2003Kam M Hui
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