Results 131 to 140 of about 2,225,287 (343)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Correlation between IL-10 and microRNA-187 expression in epileptic rat hippocampus and patients with temporal lobe epilepsy

Frontiers in Cellular Neuroscience, 2015
Accumulating evidence is emerging that microRNAs (miRs) are key regulators controlling neuroinflammatory processes, which are known to play a potential role in the pathogenesis of temporal lobe epilepsy (TLE).
Walid A. Alsharafi, Bo eXiao, Mutasem M Abuhamed, Fangfang eBi, Zhaohui eLuo   +4 more
doaj   +1 more source

Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. [PDF]

, 2010
Peroxisome proliferator-activated receptors (PPARs; PPAR-alpha, PPAR-delta, and PPAR-gamma) comprise a family of nuclear receptors that sense fatty acid levels and translate this information into altered gene transcription.
Axtell, Robert, Bhat, Roopa, Chawla, Ajay, Dugas, Jason C, Dunn, Shannon E, Johnson, Amanda, Moshkova, Marina, Mukundan, Lata, Nguyen, Kim, Sobel, Raymond A, Steinman, Lawrence, Straus, Daniel S   +11 more
core   +3 more sources

Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. [PDF]

, 1994
Peter J. Jose, D A Griffiths-Johnson, Paul Collins, Desmond T. Walsh, Redwan Moqbel, Nick Totty, O Truong, J. Justin Hsuan, Timothy J. Williams   +8 more
openalex   +1 more source

Hyperbaric oxygen treatment is associated with a decrease in cytokine levels in patients with necrotizing soft‐tissue infection [PDF]

, 2021
Morten Hedetoft, Peter Garred, Martin Bruun Madsen, Ole Hyldegaard   +3 more
openalex   +1 more source

COVID-19: consider cytokine storm syndromes and immunosuppression

The Lancet, 2020
Puja Mehta, Daniel F McAuley, Michael Brown, Emilie Sanchez, R. S. Tattersall, Jessica J. Manson   +5 more
semanticscholar   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases

Frontiers in Immunology, 2019
Inflammation underpins and contributes to the pathogenesis of many retinal degenerative diseases. The recruitment and activation of both resident microglia and recruited macrophages, as well as the production of cytokines, are key contributing factors ...
Yvette Wooff, Yvette Wooff, Si Ming Man, Riemke Aggio-Bruce, Riccardo Natoli, Riccardo Natoli, Nilisha Fernando   +6 more
doaj   +1 more source

An inflammatory cytokine signature predicts COVID-19 severity and survival

Nature Medicine, 2020
D. D. Del Valle, S. Kim-Schulze, Hsin-Hui Huang, N. Beckmann, Sharon Nirenberg, Bo Wang, Yonit Lavin, Talia H. Swartz, D. Madduri, A. Stock, T. Marron, H. Xie, Manishkumar Patel, K. Tuballes, O. Van Oekelen, Adeeb H. Rahman, P. Kovatch, J. Aberg, E. Schadt, S. Jagannath, M. Mazumdar, A. Charney, A. Firpo-Betancourt, D. R. Mendu, J. Jhang, D. Reich, K. Sigel, C. Cordon-Cardo, M. Feldmann, S. Parekh, M. Merad, S. Gnjatic   +31 more
semanticscholar   +1 more source

Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan, Ya‐Fang Chen, Cheng‐Hsuan Li, Yih‐Chih Kuo, Ni‐Chung Lee, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Tai‐Chung Tseng, Tung‐Hung Su, Chien‐Ting Hsu, Huey‐Ling Chen, Chin‐Hsien Lin, Yen‐Hsuan Ni   +12 more
wiley   +1 more source