Results 131 to 140 of about 2,261,376 (387)

Bacterial peptidoglycan levels have brain area, time of day, and sleep loss-induced fluctuations

Frontiers in Neuroscience
Sleep-inducing bacterial cell wall components isolated from brain and urine of sleep deprived animals were identified as peptidoglycan (PG) and muropeptides in the 1980s.
Erika L. English, James M. Krueger
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Coxsackie B1 virus-like particle vaccine modified to exclude a highly conserved immunoreactive region from the capsid induces potent neutralizing antibodies and protects against infection in mice

Journal of Biomedical Science
Background Enteroviruses, including Coxsackie B (CVB) viruses, can cause severe diseases such as myocarditis, pancreatitis, and meningitis. Vaccines can prevent these complications, but conserved non-neutralizing epitopes in the viral capsid may limit ...
Saana Soppela, Martín González-Rodríguez, Virginia M. Stone, Iiris Mustonen, Niila V. V. Jouppila, Vili Lampinen, Teemu Haikarainen, Malin Flodström-Tullberg, Ilkka S. Junttila, Minna M. Hankaniemi   +9 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. [PDF]

, 1996
The mechanism by which the mammalian mother accepts the implanting fetus as an allograft remains unexplained, but is likely to be the result of a combination of factors.
Abrams, JS, Corry, DB, Fisher, SJ, Litton, MJ, Locksley, RM, Roth, I   +5 more
core   +1 more source

Peripheral blood inflammatory score using a cytokine multiplex assay predicts clinical outcomes in patients treated with atezolizumab-bevacizumab for unresectable HCC

Frontiers in Immunology
BackgroundSeveral serum cytokines have been proposed as biomarkers for predicting the outcomes of patients with hepatocellular carcinoma (HCC) receiving tyrosine kinase inhibitors. However, their role in atezolizumab plus bevacizumab (AB) treatment needs
Hee Sun Cho, Hee Sun Cho, Hee Sun Cho, Soon Kyu Lee, Soon Kyu Lee, Ji Won Han, Ji Won Han, Jung Hyun Kwon, Jung Hyun Kwon, Soon Woo Nam, Soon Woo Nam, Jaejun Lee, Jaejun Lee, Keungmo Yang, Keungmo Yang, Pil Soo Sung, Pil Soo Sung, Jeong Won Jang, Jeong Won Jang, Seung Kew Yoon, Seung Kew Yoon, Jong Young Choi, Jong Young Choi   +22 more
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

The course of cytokine and chemokine gene expression in clinically suspect arthralgia patients during progression to inflammatory arthritis [PDF]

, 2023
Judith W Heutz, Cleo Rogier, Ellis Niemantsverdriet, Susan J. F. van den Eeden, Pascal H P de Jong, Erik Lubberts, Annemieke Geluk, Annette H M van der Helm–van Mil   +7 more
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Cytokine Activation Leads to Acidification and Increases Maturation of Mycobacterium avium-Containing Phagosomes in Murine Macrophages [PDF]

, 1998
Ulrich E. Schaible, Sheila Sturgill-Koszycki, Paul H. Schlesinger, David G. Russell   +3 more
openalex   +1 more source