Results 31 to 40 of about 1,542,731 (346)
Frontiers in Immunology, 2020 Circadian rhythms are a very exquisite mechanism to influence on transcriptional levels and physiological activities of various molecules that affect cell metabolic pathways.
Masato Kubo, Masato Kubo
doaj +1 more source
Journal of Clinical Investigation, 1998 Apoptosis in vivo is followed almost inevitably by rapid uptake into adjacent phagocytic cells, a critical process in tissue remodeling, regulation of the immune response, or resolution of inflammation.
V. Fadok +5 more
semanticscholar +1 more source
Journal of Immunotherapy for Cancer, 2018 During the last decade the field of cancer immunotherapy has witnessed impressive progress. Highly effective immunotherapies such as immune checkpoint inhibition, and T-cell engaging therapies like bispecific T-cell engaging (BiTE) single-chain antibody ...
A. Shimabukuro-Vornhagen +8 more
semanticscholar +1 more source
F1000Research, 2012 The recent development of mammalian target of rapamycin (mTOR) kinase domain inhibitors and genetic dissection of rapamycin-sensitive and -insensitive mTOR protein complexes (mTORC1 and mTORC2) have revealed that phosphorylation of the mTOR substrate 4E ...
Mark Livingstone, Michael Bidinosti
doaj +1 more source
Immunity, 2019 Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerbated Type 2 response.
Hamida Hammad +3 more
openaire +3 more sources
bioRxiv, 2020 The COVID-19 pandemic has caused significant morbidity and mortality. Currently, there is a critical shortage of proven treatment options and an urgent need to understand the pathogenesis of multi-organ failure and lung damage.
Rajendra Karki +15 more
semanticscholar +1 more source
Cytokine Networks in the Pathogenesis of Rheumatoid Arthritis
International Journal of Molecular Sciences, 2021 Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic inflammation causing progressive joint damage that can lead to lifelong disability. The pathogenesis of RA involves a complex network of various cytokines and cells that
N. Kondo, T. Kuroda, D. Kobayashi
semanticscholar +1 more source
Seizure, 2011 Epilepsy is a common chronic neurological disorder affecting approximately 8 out of 1000 people. Its pathophysiology, however, has remained elusive in many regards. Consequently, adequate seizure control is still lacking in about one third of patients. Cytokines are soluble mediators of cell communication that are critical in immune regulation.
Braxton A. Norwood +8 more
openaire +3 more sources
Current concepts in the diagnosis and management of cytokine release syndrome.
Blood, 2014 As immune-based therapies for cancer become potent, more effective, and more widely available, optimal management of their unique toxicities becomes increasingly important.
Daniel W. Lee +7 more
semanticscholar +1 more source
On the Alert for Cytokine Storm: Immunopathology in COVID‐19
Arthritis & Rheumatology, 2020 Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care ...
L. Henderson +18 more
semanticscholar +1 more source