Results 31 to 40 of about 2,184,274 (341)

Immunopathogenesis and treatment of cytokine storm in COVID-19

Theranostics, 2021
Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-inflammation, acute respiratory distress syndrome, and multiple organ failure.
Jae Seok Kim, Jun Young Lee, Jae-Won Yang, Keumwha Lee, M. Effenberger, W. Szpirt, A. Kronbichler, J. Shin   +7 more
semanticscholar   +1 more source

Amyloid beta and diabetic pathology cooperatively stimulate cytokine expression in an Alzheimer's mouse model [PDF]

, 2020
Background Diabetes is a risk factor for developing Alzheimer's disease (AD); however, the mechanism by which diabetes can promote AD pathology remains unknown.
Fernández Ponce, Cecilia Matilde, García Alloza, Mónica, Hierro-Bujalance, Carmen, Infante-Garcia, Carmen, Ramos-Rodríguez, Juan José, Sankar, Sitara B., Weinstock, Laura D., Wood, Levi B.   +7 more
core   +3 more sources

Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

Scientific Reports, 2017
The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with GR’s ligand ...
Ioanna Petta, Nadia Bougarne, Jolien Vandewalle, Lien Dejager, Sofie Vandevyver, Marlies Ballegeer, Sofie Desmet, Jonathan Thommis, Lode De Cauwer, Sam Lievens, Claude Libert, Jan Tavernier, Karolien De Bosscher   +12 more
doaj   +1 more source

Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: A multicenter study [PDF]

, 2008
The increase of proinflammatory cytokines in vaginal secretions may serve as a surrogate marker of unwanted inflammatory reaction to microbicide products topically applied for the prevention of sexually transmitted diseases, including HIV-1. Interleukin (
Alfano, M, Belec, L, Carbonneil, C, Chen, S, Cosentino, L, Cummins, JE, Curtis, K, Dezzutti, CS, Donaghay, M, Doncel, GF, Donoval, B, Fichorova, RN, Grivel, JC, Guzman, E, Hayes, M, Herold, B, Hillier, S, Lackman-Smith, C, Landay, A, Margolis, L, Mayer, KH, Pallansch-Cokonis, M, Pasicznyk, JM, Poli, G, Reichelderfer, P, Richardson-Harman, N, Roberts, P, Rodriguez, I, Saidi, H, Sassi, RR, Shattock, R   +30 more
core   +2 more sources

COVID-19 spike polypeptide vaccine reduces the pathogenesis and viral infection in a mouse model of SARS-CoV-2

Frontiers in Immunology, 2023
The SARS-CoV-2 coronavirus, which causes a respiratory disease called COVID-19, has been declared a pandemic by the World Health Organization (WHO) and is still ongoing. Vaccination is the most important strategy to end the pandemic.
Yasmin Hisham, Sun-Min Seo, Sinae Kim, Sinae Kim, Saerok Shim, Jihyeong Hwang, Eun-Seon Yoo, Na-Won Kim, Chang-Seon Song, Hyunjhung Jhun, Ho-Young Park, Youngmin Lee, Kyeong-Cheol Shin, Sun-Young Han, Je Kyung Seong, Je Kyung Seong, Yang-Kyu Choi, Soohyun Kim, Soohyun Kim   +18 more
doaj   +1 more source

Salivary cytokine panel indicative of non-small cell lung cancer. [PDF]

, 2018
Objective To develop a combinatorial panel of salivary cytokines that manifests the presence of non-small cell lung cancer (NSCLC) that will eventually improve prognosis by facilitating the early diagnosis and management of this common cancer. Methods We
Koizumi, Tomonobu, Shetty, Vivek, Yamaguchi, Masaki   +2 more
core   +3 more sources

The lymph node transcriptome of unicentric and idiopathic multicentric Castleman disease

Haematologica, 2022
Castleman disease is a polyclonal lymphoproliferative disorder characterized by unicentric or multicentric lymphadenopathy with characteristic histomorphological features, in addition to variable inflammatory symptomatology. The molecular mechanisms and
Pedro Horna, Rebecca L. King, Dragan Jevremovic, David C. Fajgenbaum, Angela Dispenzieri   +4 more
doaj   +1 more source

Ex vivo innate immune cytokine signature of enhanced risk of relapsing brucellosis. [PDF]

, 2013
BackgroundBrucellosis, a zoonotic infection caused by one of the Gram-negative intracellular bacteria of the Brucella genus, is an ongoing public health problem in Perú.
Feldman, Kristyn E, Gilman, Robert H, Gotuzzo, Eduardo, Hoffmann, Alexander, Loriaux, Paul M, Saito, Mayuko, Siva, Tenaya, Tuero, Iskra, Villaverde, Homarh, Vinetz, Joseph M   +9 more
core   +3 more sources

Cytokine Storm

New England Journal of Medicine, 2020
From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory (D.C.F.), and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy (C.H.J ...
D. Fajgenbaum, C. June
semanticscholar   +1 more source

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

Frontiers in Immunology, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes coronavirus disease 2019 (COVID-19). As of 25 May 2020, the outbreak of COVID-19 has caused 347,192 deaths around the world.
Yujun Tang, Jiajia Liu, Dingyi Zhang, Zhenghao Xu, Jinjun Ji, Chengping Wen   +5 more
semanticscholar   +1 more source