Results 31 to 40 of about 799,218 (270)

Altered Plasma Metabolic Profiles in Chinese Patients With Multiple Sclerosis

Frontiers in Immunology, 2021
Multiple sclerosis (MS) is an autoimmune disease that leads to the demyelination of nerve axons. An increasing number of studies suggest that patients with MS exhibit altered metabolic profiles, which might contribute to the course of MS.
Fan Yang, Fan Yang, Fan Yang, Shao-chang Wu, Zong-xin Ling, Zong-xin Ling, Shan Chao, Li-juan Zhang, Xiu-mei Yan, Lin He, Li-mei Yu, Long-you Zhao   +11 more
doaj   +1 more source

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

Journal of Clinical Investigation, 1998
Apoptosis in vivo is followed almost inevitably by rapid uptake into adjacent phagocytic cells, a critical process in tissue remodeling, regulation of the immune response, or resolution of inflammation.
V. Fadok, D. Bratton, A. Konowal, Peter W. Freed, J. Westcott, P. Henson   +5 more
semanticscholar   +1 more source

Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor

Frontiers in Immunology, 2021
Interleukin-1 (IL-1) family cytokines are potent mediators of inflammation, acting to coordinate local and systemic immune responses to a wide range of stimuli. Aberrant signaling by IL-1 family cytokine members, however, is linked to myriad inflammatory
James K. Fields, James K. Fields, James K. Fields, Kyle Kihn, Gabriel S. Birkedal, Erik H. Klontz, Erik H. Klontz, Erik H. Klontz, Kjell Sjöström, Sebastian Günther, Robert Beadenkopf, Göran Forsberg, David Liberg, Greg A. Snyder, Greg A. Snyder, Daniel Deredge, Eric J. Sundberg   +16 more
doaj   +1 more source

Genetic Regulation of Cytokine Response in Patients with Acute Community-acquired Pneumonia [PDF]

arXiv, 2021
Background: Community-acquired pneumonia (CAP) is an acute disease condition with a high risk of rapid deteriorations. We analysed the influence of genetics on cytokine regulation to obtain a better understanding of patient's heterogeneity. Methods: For up to N=389 genotyped participants of the PROGRESS study of hospitalised CAP patients, we performed ...
arxiv  

Cytokine release syndrome

Journal of Immunotherapy for Cancer, 2018
During the last decade the field of cancer immunotherapy has witnessed impressive progress. Highly effective immunotherapies such as immune checkpoint inhibition, and T-cell engaging therapies like bispecific T-cell engaging (BiTE) single-chain antibody ...
A. Shimabukuro-Vornhagen, Philipp Gödel, M. Subklewe, H. Stemmler, H. Schlößer, M. Schlaak, M. Kochanek, B. Böll, M. von Bergwelt-Baildon   +8 more
semanticscholar   +1 more source

ACE2 Expression in Organotypic Human Airway Epithelial Cultures and Airway Biopsies

Frontiers in Pharmacology, 2022
Coronavirus disease 2019 (COVID-19) caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an acute respiratory disease with systemic complications.
Qianyu Chen, Qianyu Chen, Shenna Langenbach, Shenna Langenbach, Meina Li, Meina Li, Yuxiu C. Xia, Xumei Gao, Xumei Gao, Matthew J. Gartner, Elizabeth A. Pharo, Sinéad M. Williams, Shawn Todd, Nadeene Clarke, Sarath Ranganathan, Sarath Ranganathan, Michelle L. Baker, Kanta Subbarao, Kanta Subbarao, Alastair G. Stewart, Alastair G. Stewart   +20 more
doaj   +1 more source

Modeling Microglia Activation and Inflammation-Based Neuroprotectant Strategies During Ischemic Stroke [PDF]

Bulletin of Mathematical Biology 83 (2021) 72, 2020
Neural inflammation immediately follows the onset of ischemic stroke. During this process, microglial cells can be activated into two different phenotypes: the M1 phenotype, which can worsen brain injury by producing pro-inflammatory cytokines; or the M2 phenotype, which can aid in long term recovery by producing anti-inflammatory cytokines.
arxiv   +1 more source

Mitochondrial Displacement Loop Region SNPs Modify Sjögren’s Syndrome Development by Regulating Cytokines Expression in Female Patients

Frontiers in Genetics, 2022
Mitochondrial dysfunction could induce innate immune response with cytokines releasing to initiate Sjögren’s syndrome (SS) onset. Single nucleotide polymorphisms (SNPs) in the mitochondrial displacement loop (D-loop) and mitochondrial DNA (mtDNA) copy ...
Yufei Zhao, Chenxing Peng, Jingjing Zhang, Ruixue Lai, Xiaoyun Zhang, Zhanjun Guo   +5 more
doaj   +1 more source

A Fast Second-Order Explicit Predictor-Corrector Numerical Technique To Investigating And Predicting The Dynamic Of Cytokine Levels And Human Immune Cells Activation In Response To Gram-Positive Bacteria: Staphylococcus Aureus [PDF]

arXiv, 2023
This paper develops a second-order explicit predictor-corrector numerical approach for solving a mathematical model on the dynamic of cytokine expressions and human immune cell activation in response to the bacterium staphylococcus aureus (S. aureus). The proposed algorithm is at least zero-stable and second-order accurate.
arxiv  

Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

bioRxiv, 2020
The COVID-19 pandemic has caused significant morbidity and mortality. Currently, there is a critical shortage of proven treatment options and an urgent need to understand the pathogenesis of multi-organ failure and lung damage.
Rajendra Karki, B. Sharma, Shraddha Tuladhar, E. P. Williams, Lillian Zalduondo, Parimal Samir, Min Zheng, Balamurugan Sundaram, B. Banoth, R. Malireddi, P. Schreiner, G. Neale, P. Vogel, R. Webby, C. Jonsson, T. Kanneganti   +15 more
semanticscholar   +1 more source