Results 21 to 30 of about 1,857,465 (364)

COVID-19 spike polypeptide vaccine reduces the pathogenesis and viral infection in a mouse model of SARS-CoV-2

open access: yesFrontiers in Immunology, 2023
The SARS-CoV-2 coronavirus, which causes a respiratory disease called COVID-19, has been declared a pandemic by the World Health Organization (WHO) and is still ongoing. Vaccination is the most important strategy to end the pandemic.
Yasmin Hisham   +18 more
doaj   +1 more source

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

open access: yesCytokine & growth factor reviews, 2020
Highlights • COVID-19 pandemic is raging worldwide and is putting health-care systems under severe strain.• The “cytokine storm” and the subsequent ARDS result from the effects of the combination of several immune-active molecules.• The “cytokine storm ...
F. Coperchini   +4 more
semanticscholar   +1 more source

Effect of Recombinant α1-Antitrypsin Fc-Fused (AAT-Fc) Protein on the Inhibition of Inflammatory Cytokine Production and Streptozotocin-Induced Diabetes

open access: yesMolecular Medicine, 2013
α1-Antitrypsin (AAT) is a member of the serine proteinase inhibitor family that impedes the enzymatic activity of serine proteinases, including human neutrophil elastase, cathepsin G and neutrophil proteinase 3.
Siyoung Lee   +11 more
doaj   +1 more source

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

open access: yesMolecules, 2014
Curcumin (diferuloylmethane), a golden pigment from turmeric, has been linked with antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antidiabetic properties. Most of the these activities have been assigned to methoxy, hydroxyl, α,
Bharat B. Aggarwal   +2 more
doaj   +1 more source

Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

open access: yesCell Stress, 2020
Natural products and traditional herbal medicine are an important source of alternative bioactive compounds but very few plant-based preparations have been scientifically evaluated and validated for their potential as medical treatments.
Alejandra Gomez-Cadena   +3 more
doaj   +1 more source

The lymph node transcriptome of unicentric and idiopathic multicentric Castleman disease

open access: yesHaematologica, 2022
Castleman disease is a polyclonal lymphoproliferative disorder characterized by unicentric or multicentric lymphadenopathy with characteristic histomorphological features, in addition to variable inflammatory symptomatology. The molecular mechanisms and
Pedro Horna   +4 more
doaj   +1 more source

Cytokines and autoimmunity [PDF]

open access: yesClinical and Experimental Immunology, 1994
SUMMARYAlthough the immunopathology of most autoimmune diseases has been well defined, the mechanisms responsible for the breakdown of self-tolerance and which lead to the development of systematic and organ-specific autoaggression are still unclear. Evidence has accumulated which supports a role for a disregulated production of cytokines by leucocytes
CAVALLO, Maria Gisella   +2 more
openaire   +3 more sources

Cytokine Storm

open access: yesNew England Journal of Medicine, 2020
From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory (D.C.F.), and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy (C.H.J ...
D. Fajgenbaum, C. June
semanticscholar   +1 more source

Immunopharmacological aspects of the cytokine system

open access: yesБюллетень сибирской медицины, 2019
Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common ...
A. S. Simbirtsev
doaj   +1 more source

Cytokines and Disease [PDF]

open access: yesMediators of Inflammation, 2014
Recent evidence in biology and medicine has expanded the knowledge of cytokines function in many disease states and conditions as well as the severe adverse effects implicated in the escalated production associated with specific disease conditions.
Arkadiusz Orzechowski   +3 more
openaire   +4 more sources

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