Results 21 to 30 of about 1,481,271 (307)

Effect of Recombinant α1-Antitrypsin Fc-Fused (AAT-Fc) Protein on the Inhibition of Inflammatory Cytokine Production and Streptozotocin-Induced Diabetes

open access: yesMolecular Medicine, 2013
α1-Antitrypsin (AAT) is a member of the serine proteinase inhibitor family that impedes the enzymatic activity of serine proteinases, including human neutrophil elastase, cathepsin G and neutrophil proteinase 3.
Siyoung Lee   +11 more
doaj   +1 more source

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

open access: yesMolecules, 2014
Curcumin (diferuloylmethane), a golden pigment from turmeric, has been linked with antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antidiabetic properties. Most of the these activities have been assigned to methoxy, hydroxyl, α,
Bharat B. Aggarwal   +2 more
doaj   +1 more source

Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

open access: yesCell Stress, 2020
Natural products and traditional herbal medicine are an important source of alternative bioactive compounds but very few plant-based preparations have been scientifically evaluated and validated for their potential as medical treatments.
Alejandra Gomez-Cadena   +3 more
doaj   +1 more source

The lymph node transcriptome of unicentric and idiopathic multicentric Castleman disease

open access: yesHaematologica, 2022
Castleman disease is a polyclonal lymphoproliferative disorder characterized by unicentric or multicentric lymphadenopathy with characteristic histomorphological features, in addition to variable inflammatory symptomatology. The molecular mechanisms and
Pedro Horna   +4 more
doaj   +1 more source

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma [PDF]

open access: yes, 2017
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP as a
Beyaert, Rudi   +14 more
core   +3 more sources

Immunopharmacological aspects of the cytokine system

open access: yesБюллетень сибирской медицины, 2019
Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common ...
A. S. Simbirtsev
doaj   +1 more source

Serum cholestenoic acid as a potential marker of pulmonary cholesterol homeostasis

open access: yesJournal of Lipid Research, 2004
The conversion of cholesterol into the more polar metabolites 27-hydroxycholesterol (27-OH) and cholestenoic acid by the cytochrome P450 sterol 27-hydroxylase is a cholesterol-removal mechanism used by almost all cells.
Steve Meaney   +5 more
doaj   +1 more source

Environmental and microbial factors influence affective and cognitive behavior in C57BL/6 sub-strains

open access: yesFrontiers in Immunology, 2023
C57BL/6 mice are one of the most widely used inbred strains in biomedical research. Early separation of the breeding colony has led to the development of several sub-strains.
Nada Abdel Aziz   +10 more
doaj   +1 more source

Cytokine Modulation of Keratinocyte Cytokines

open access: yesJournal of Investigative Dermatology, 1990
There is increasing evidence that epidermal cytokines may have an important role in mediating inflammatory and immune responses in the skin. A number of cell types in the epidermis are capable of secreting cytokines including keratinocytes, Langerhans cells, melanocytic cells, and even Merkle cells.
Ansel, John   +7 more
openaire   +2 more sources

Cytokines of Birds: Conserved Functions [PDF]

open access: yes, 2001
Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine signaling cascades convincingly revealed the important roles of these molecules in immunologic processes. Cytokines are used at present as drugs to fight
Göbel, Thomas W. F.   +4 more
core   +1 more source

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