Results 21 to 30 of about 1,176,895 (316)

Engineering cytokines and cytokine circuits

open access: yesScience, 2020
Learning to speak the secret language of immune cells could improve ...
Aileen W, Li, Wendell A, Lim
openaire   +3 more sources

Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

open access: yesScientific Reports, 2017
The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with GR’s ligand ...
Ioanna Petta   +12 more
doaj   +1 more source

Effect of Recombinant α1-Antitrypsin Fc-Fused (AAT-Fc) Protein on the Inhibition of Inflammatory Cytokine Production and Streptozotocin-Induced Diabetes

open access: yesMolecular Medicine, 2013
α1-Antitrypsin (AAT) is a member of the serine proteinase inhibitor family that impedes the enzymatic activity of serine proteinases, including human neutrophil elastase, cathepsin G and neutrophil proteinase 3.
Siyoung Lee   +11 more
doaj   +1 more source

Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

open access: yesCell Stress, 2020
Natural products and traditional herbal medicine are an important source of alternative bioactive compounds but very few plant-based preparations have been scientifically evaluated and validated for their potential as medical treatments.
Alejandra Gomez-Cadena   +3 more
doaj   +1 more source

The lymph node transcriptome of unicentric and idiopathic multicentric Castleman disease

open access: yesHaematologica, 2022
Castleman disease is a polyclonal lymphoproliferative disorder characterized by unicentric or multicentric lymphadenopathy with characteristic histomorphological features, in addition to variable inflammatory symptomatology. The molecular mechanisms and
Pedro Horna   +4 more
doaj   +1 more source

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

open access: yesMolecules, 2014
Curcumin (diferuloylmethane), a golden pigment from turmeric, has been linked with antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antidiabetic properties. Most of the these activities have been assigned to methoxy, hydroxyl, α,
Bharat B. Aggarwal   +2 more
doaj   +1 more source

COVID-19 spike polypeptide vaccine reduces the pathogenesis and viral infection in a mouse model of SARS-CoV-2

open access: yesFrontiers in Immunology, 2023
The SARS-CoV-2 coronavirus, which causes a respiratory disease called COVID-19, has been declared a pandemic by the World Health Organization (WHO) and is still ongoing. Vaccination is the most important strategy to end the pandemic.
Yasmin Hisham   +18 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis. [PDF]

open access: yesAnn Clin Transl Neurol
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Bruno A   +19 more
europepmc   +2 more sources

Immunopharmacological aspects of the cytokine system

open access: yesБюллетень сибирской медицины, 2019
Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common ...
A. S. Simbirtsev
doaj   +1 more source

Cytokines and Disease [PDF]

open access: yesMediators of Inflammation, 2014
Recent evidence in biology and medicine has expanded the knowledge of cytokines function in many disease states and conditions as well as the severe adverse effects implicated in the escalated production associated with specific disease conditions.
Arkadiusz Orzechowski   +3 more
openaire   +5 more sources

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