Results 31 to 40 of about 1,857,465 (364)

Serum cholestenoic acid as a potential marker of pulmonary cholesterol homeostasis

Journal of Lipid Research, 2004
The conversion of cholesterol into the more polar metabolites 27-hydroxycholesterol (27-OH) and cholestenoic acid by the cytochrome P450 sterol 27-hydroxylase is a cholesterol-removal mechanism used by almost all cells.
Steve Meaney, Tracey L. Bonfield, Magnus Hansson, Amir Babiker, Mani S. Kavuru, Mary Jane Thomassen   +5 more
doaj   +1 more source

Environmental and microbial factors influence affective and cognitive behavior in C57BL/6 sub-strains

Frontiers in Immunology, 2023
C57BL/6 mice are one of the most widely used inbred strains in biomedical research. Early separation of the breeding colony has led to the development of several sub-strains.
Nada Abdel Aziz, Nada Abdel Aziz, Nada Abdel Aziz, Inssaf Berkiks, Inssaf Berkiks, Paballo Mosala, Paballo Mosala, Tiroyaone M. Brombacher, Tiroyaone M. Brombacher, Frank Brombacher, Frank Brombacher   +10 more
doaj   +1 more source

Engineering cytokine therapeutics

Nature Reviews Bioengineering, 2023
Cytokines have pivotal roles in immunity, making them attractive as therapeutics for a variety of immune-related disorders. However, the widespread clinical use of cytokines has been limited by their short blood half-lives and severe side effects caused ...
Jeroen Deckers, Tom Anbergen, Ayla M. Hokke, Anne de Dreu, David P. Schrijver, Koen de Bruin, Y. C. Toner, Thijs J. Beldman, Jamie B. Spangler, T. D. de Greef, F. Grisoni, R. van der Meel, L. Joosten, M. Merkx, M. Netea, W. Mulder   +15 more
semanticscholar   +1 more source

Diurnal Rhythmicity Programs of Microbiota and Transcriptional Oscillation of Circadian Regulator, NFIL3

Frontiers in Immunology, 2020
Circadian rhythms are a very exquisite mechanism to influence on transcriptional levels and physiological activities of various molecules that affect cell metabolic pathways.
Masato Kubo, Masato Kubo
doaj   +1 more source

Immunopathogenesis and treatment of cytokine storm in COVID-19

Theranostics, 2021
Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-inflammation, acute respiratory distress syndrome, and multiple organ failure.
Jae Seok Kim, Jun Young Lee, Jae-Won Yang, Keumwha Lee, M. Effenberger, W. Szpirt, A. Kronbichler, J. Shin   +7 more
semanticscholar   +1 more source

Complex cytokine profiles induced by BCG vaccination in UK infants. [PDF]

, 2009
IFNgamma plays an important part in immunity to tuberculosis (TB), but although it is necessary, it is not on its own sufficient for protection against TB.
Fine, Paul E, Fine, Paul E., Hazel M. Dockrell, Dockrell, Hazel M., Floyd, Sian, Weir, Rosemary E., Paul E. Fine, Rose Blitz, Blitz, Rose, Maeve K. Lalor, Lalor, Maeve K., Steven G. Smith, Weir, Rosemary E, Smith, Steven G., Keith Branson, Smith, Steven G, Lalor, Maeve K, Dockrell, Hazel M, Gorak-Stolinska, Patricia, Rosemary E. Weir, Branson, Keith, Patricia Gorak-Stolinska, Sian Floyd   +22 more
core   +1 more source

The Ratio of Plasma angiopoietin-2 to angiopoietin-1 as a Prognostic Biomarker in Patients With Sepsis

, 2020
Background: We aimed to investigate the role of angiopoietin (Angpt) as a predictive biomarker for sepsis by evaluating associations between plasma Angpt and various inflammatory cytokines and mortality in critically ill patients with sepsis ...
이수환, 설창환, 임아영, 정경수, 용승현, 박무석, 김영삼   +6 more
core   +1 more source

BCG vaccination induces different cytokine profiles following infant BCG vaccination in the UK and Malawi [PDF]

, 2011
BACKGROUND: BCG vaccination of infants is thought to provide good protection in all settings. This study investigated whether Malawian infants made weaker responses across a cytokine panel after BCG vaccination, compared with UK infants.METHODS: Diluted ...
Hazel M. Dockrell, Newport, Melanie J, Mvula, Hazzie, Weir, Rosemary E., Rose Blitz, Fine, P.E., Steven G. Smith, Nuala McGrath (230042), Crampin, Amelia C, Keith Branson (239422), Hazel M Dockrell (10414616), Sian Floyd, Fine, Paul E, Crampin, Amelia C., Weir, R.E., McGrath, N., Floyd, Sian, Rose Blitz (356877), Newport, M.J., Anne Ben-Smith (244056), Melanie Newport (4461202), Lalor, Maeve K., Hazzie Mvula, Lalor, M.K., Maeve K Lalor (16181825), Sian Floyd (239400), Weir, Rosemary E, Lalor, Maeve K, Gorak-Stolinska, P., Fine, Paul E., Nuala McGrath, Crampin, A.C., Ben-Smith, A., Steven G Smith (16181831), Maeve K. Lalor, Hazzie Mvula (271278), Smith, S.G., Mvula, H., Smith, Steven G., Smith, Steven G, Patricia Gorak-Stolinska (356875), Floyd, S., Blitz, R., McGrath, Nuala, Amelia C. Crampin, Gorak-Stolinska, Patricia, Rosemary E. Weir, Branson, K., Amelia C Crampin (10281422), Ben-Smith, Anne, Dockrell, Hazel M., Paul E. Fine, Paul E Fine (16181834), Blitz, Rose, Dockrell, H.M., Rosemary E Weir (16181828), Keith Branson, Anne Ben-Smith, Dockrell, Hazel M, Newport, Melanie J., Branson, Keith, Patricia Gorak-Stolinska, Melanie J. Newport   +62 more
core   +1 more source

Cytokine Modulation of Keratinocyte Cytokines

Journal of Investigative Dermatology, 1990
There is increasing evidence that epidermal cytokines may have an important role in mediating inflammatory and immune responses in the skin. A number of cell types in the epidermis are capable of secreting cytokines including keratinocytes, Langerhans cells, melanocytic cells, and even Merkle cells.
Ansel, John, Perry, Patricia, Brown, Jeffrey, Damm, David, Phan, Tuan, Hart, Charles, Luger, Thomas, Hefeneider, Stephen   +7 more
openaire   +2 more sources

Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

Autoimmunity Reviews, 2020
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December 2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up extraordinary challenges.
Y. Jamilloux, T. Henry, A. Belot, S. Viel, M. Fauter, T. El Jammal, T. Walzer, B. François, P. Sève   +8 more
semanticscholar   +1 more source