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The ‘Cytokine Storm’: molecular mechanisms and therapeutic prospects
Trends in immunology, 2021 Cytokine storm syndrome has generally been described as a collection of clinical manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are associated with various pathologies, as observed in infectious diseases, certain ...
Rajendra Karki, T. Kanneganti
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, 2015 As a potent immune regulator, heat shock protein 70 derived from Mycobacterium tuberculosis (Mtb Hsp70) has adjuvant effect and activates immune cells such as macrophages and dendritic cells (DCs). Although Toll-like receptors (TLRs) are known to involve
신성재
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Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies
Frontiers in Immunology, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes coronavirus disease 2019 (COVID-19). As of 25 May 2020, the outbreak of COVID-19 has caused 347,192 deaths around the world.
Yujun Tang +5 more
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, 2015 Der f 1, a major house dust mite allergen and member of the papain-like cysteine protease family, can provoke immune responses with its proteolytic activity.
김태윤 +5 more
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, 2020 The COVID-19 pandemic has led to twin public health and economic crises around the world. Not only has it cost hundreds of thousands of lives but also severely impacted livelihoods and placed enormous strain on community healthcare and welfare services ...
Mahmud-Al-Rafat, Abdullah +9 more
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F1000Research, 2012 The recent development of mammalian target of rapamycin (mTOR) kinase domain inhibitors and genetic dissection of rapamycin-sensitive and -insensitive mTOR protein complexes (mTORC1 and mTORC2) have revealed that phosphorylation of the mTOR substrate 4E ...
Mark Livingstone, Michael Bidinosti
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Interleukin-10: A double-edged sword in breast cancer
Tzu Chi Medical Journal, 2021 Breast cancer (BC) is a frequently diagnosed cancer among women worldwide. Currently, BC can be divided into different subgroups according to the presence of the following hormone receptors: estrogen receptor, progesterone receptor, and human epidermal ...
Chun-Ming Chang +3 more
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Journal of Immunotherapy for Cancer, 2018 During the last decade the field of cancer immunotherapy has witnessed impressive progress. Highly effective immunotherapies such as immune checkpoint inhibition, and T-cell engaging therapies like bispecific T-cell engaging (BiTE) single-chain antibody ...
A. Shimabukuro-Vornhagen +8 more
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, 2017 Mycobacterium tuberculosis is a causative agent leading to pleural effusion, characterized by the accumulation of fluid and immune cells in the pleural cavity.
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International Journal of Obesity, 1998 Cytokines inhibit feeding through peripheral and brain mechanisms. Behavioral, cellular, and molecular studies show that interactions among cytokines, neurotransmitters, and peptides and modulation of hypothalamic neurons are involved in cytokine-induced feeding inhibition.
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