Results 41 to 50 of about 799,218 (270)
F1000Research, 2012 The recent development of mammalian target of rapamycin (mTOR) kinase domain inhibitors and genetic dissection of rapamycin-sensitive and -insensitive mTOR protein complexes (mTORC1 and mTORC2) have revealed that phosphorylation of the mTOR substrate 4E ...
Mark Livingstone, Michael Bidinosti
doaj +1 more source
Microbiology Spectrum, 2022 The vascular endothelial injury occurs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, but the mechanisms are poorly understood.
Anita Kovacs-Kasa +8 more
doaj +1 more source
Stochastic approach to study the properties of the complex patterns observed in cytokine and T-cells interaction process [PDF]
arXiv, 2022 Patterns in complex systems store hidden information of the system which is needed to be explored. We present a simple model of cytokine and T-cells interaction and studied the model within stochastic framework by constructing Master equation of the system and solving it.
arxiv
Current concepts in the diagnosis and management of cytokine release syndrome.
Blood, 2014 As immune-based therapies for cancer become potent, more effective, and more widely available, optimal management of their unique toxicities becomes increasingly important.
Daniel W. Lee +7 more
semanticscholar +1 more source
Journal of Leukocyte Biology, 2020 Clinical evidence indicates that the fatal outcome observed with severe acute respiratory syndrome‐coronavirus‐2 infection often results from alveolar injury that impedes airway capacity and multi‐organ failure—both of which are associated with the ...
Jin Wang +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2022 The transforming growth factor-βs (TGF-βs) are multifunctional cytokines capable of regulating a wide range of cellular behaviors and play a key role in maintaining the homeostasis of the immune system.
Siqi Liu +23 more
doaj +1 more source
On the Alert for Cytokine Storm: Immunopathology in COVID‐19
Arthritis & Rheumatology, 2020 Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care ...
L. Henderson +18 more
semanticscholar +1 more source
Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer
Gastroenterology Research and Practice, 2015 Gastrointestinal (GI) cancer, a cancer of different organs of the digestive system, is one of the most common cancers around the world. The incidence and death rate of some of these cancers are very high.
Sahdeo Prasad, Amit K. Tyagi
doaj +1 more source
From secretome analysis to immunology: chitosan induces major alterations in the activation of dendritic cells via a TLR4-dependent mechanism [PDF]
Mol Cell Proteomics 8, 6 (2009) 1252-64, 2009 Dendritic cells are known to be activated by a wide range of microbial products, leading to cytokine production and increased levels of membrane markers such as major histocompatibility complex class II molecules. Such activated dendritic cells possess the capacity to activate na\"ive T cells.
arxiv +1 more source
The dual nature of TDC – bridging dendritic and T cells in immunity
FEBS Letters, EarlyView.TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source