Results 51 to 60 of about 799,218 (270)

A thermodynamical perspective of immune capabilities [PDF]

Journal of Theoretical Biology 287 (2011) 48-63, 2011
We consider the mutual interactions, via cytokine exchanges, among helper lymphocytes, B lymphocytes and killer lymphocytes, and we model them as a unique system by means of a tripartite network. Each part includes all the different clones of the same lymphatic subpopulation, whose couplings to the others are either excitatory or inhibitory (mirroring ...
arxiv   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Mucosal Associated Invariant T Cells Were Activated and Polarized Toward Th17 in Chronic Obstructive Pulmonary Disease

Frontiers in Immunology, 2021
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by airway limitation accompanied with infiltration of inflammatory cells.
Wenjia Qiu, Ning Kang, Yanxu Wu, Yongjun Cai, Li Xiao, Haiyan Ge, Huili Zhu   +6 more
doaj   +1 more source

Potential of proteasome inhibitors to inhibit cytokine storm in critical stage COVID-19 patients [PDF]

arXiv, 2020
Patients infected with SARS-CoV-2 show a wide spectrum of clinical manifestations ranging from mild febrile illness and cough up to acute respiratory distress syndrome, multiple organ failure and death. Data from patients with severe clinical manifestations compared to patients with mild symptoms indicate that highly dysregulated exuberant inflammatory
arxiv  

Asporin expression is highly regulated in human chondrocytes [PDF]

Molecular Medicine, Feinstein Institute for Medical Research, 2010, 17 (7-8), pp.816-23, 2015
A significant association between a polymorphism in the D repeat of the gene encoding asporin and osteoarthritis, the most frequent of articular diseases, has been recently reported. The goal of the present study was to investigate the expression of this new class I small leucine-rich proteoglycan (SLRP) in human articular chondrocytes.
arxiv   +1 more source

Cytokine Storm in COVID-19—Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper

Frontiers in Immunology, 2020
Cytokine storm is an acute hyperinflammatory response that may be responsible for critical illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure.
S. Bhaskar, A. Sinha, Maciej Banach, S. Mittoo, Robert Weissert, J. Kass, Santhosh K. Rajagopal, Anupama R Pai, S. Kutty   +8 more
semanticscholar   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Neutralizing Anti-IL-17A Antibody Demonstrates Preclinical Activity Enhanced by Vinblastine in Langerhans Cell Histiocytosis

Frontiers in Oncology, 2022
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasm characterised by the accumulation into granulomas of apoptosis-resistant pathological dendritic cells (LCH-DCs). LCH outcome ranges from self-resolving to fatal.
Selma Olsson Åkefeldt, Selma Olsson Åkefeldt, Selma Olsson Åkefeldt, Mohamad Bachar Ismail, Mohamad Bachar Ismail, Mohamad Bachar Ismail, Alexandre Belot, Alexandre Belot, Alexandre Belot, Giulia Salvatore, Giulia Salvatore, Nathalie Bissay, Nathalie Bissay, Désirée Gavhed, Désirée Gavhed, Maurizio Aricò, Jan-Inge Henter, Jan-Inge Henter, Hélène Valentin, Christine Delprat, Christine Delprat   +20 more
doaj   +1 more source

Characterization of differences in immune responses during bolus and continuous infusion endotoxin challenges using mathematical modeling [PDF]

arXiv, 2023
Endotoxin administration is commonly used to study the inflammatory response, and though traditionally given as a bolus injection, it can be administered as a continuous infusion over multiple hours. Several studies hypothesize that the latter better represents the prolonged and pronounced inflammation observed in conditions like sepsis.
arxiv  

A mathematical model of granulopoiesis incorporating the negative feedback dynamics and kinetics of G-CSF/neutrophil binding and internalisation [PDF]

Bulletin of Mathematical Biology, 78(12). 2304-2357 (2016), 2015
We develop a physiological model of granulopoiesis which includes explicit modelling of the kinetics of the cytokine granulocyte colony-stimulating factor (G-CSF) incorporating both the freely circulating concentration and the concentration of the cytokine bound to mature neutrophils.
arxiv   +1 more source