Results 71 to 80 of about 1,481,271 (307)

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

eLife, 2017
Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation.
Ignacio Moraga, Jamie B Spangler, Juan L Mendoza, Milica Gakovic, Tom S Wehrman, Peter Krutzik, K Christopher Garcia   +6 more
doaj   +1 more source

Placental-mediated increased cytokine response to lipopolysaccharides: a potential mechanism for enhanced inflammation susceptibility of the preterm fetus. [PDF]

, 2012
BackgroundCerebral palsy is a nonprogressive motor impairment syndrome that has no effective cure. The etiology of most cases of cerebral palsy remains unknown; however, recent epidemiologic data have demonstrated an association between fetal neurologic ...
Belkacemi, Louiza, Beloosesky, Ron, Boles, Julie L, Desai, Mina, Ross, Michael G   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Increase in Vascular Endothelial Growth Factor (VEGF) Expression and the Pathogenesis of iMCD-TAFRO

Biomedicines
TAFRO (thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (F/R), renal failure (R), and organomegaly (O)) is a heterogeneous clinical subtype of idiopathic multicentric Castleman disease (iMCD) associated with a significantly poorer ...
Gordan Srkalovic, Sally Nijim, Maya Blanka Srkalovic, David Fajgenbaum   +3 more
doaj   +1 more source

Inhaled Interleukin-10 before and after induction of experimental endotoxemia in the rat : effects on the inflammatory response [PDF]

, 2007
To determine the effects of inhaled IL-10 at different doses and different time points on the pulmonary and systemic inflammatory response during endotoxemia, 48 ventilated, anaesthetized rats (mean body weight ± standard deviation, 500 ± 33g) were ...
Nguyen, Ngoc-Thach
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Breast-implant associated unicentric castleman disease: a case report

Current Problems in Cancer: Case Reports
ALK-negative anaplastic large cell lymphoma is a well-established hematologic complication of prosthetic breast implantation, but other rare conditions should also be considered.
Saishravan Shyamsundar, Mateo Sarmiento Bustamante, Larissa Borys, Megan S. Lim, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Gordan Srkalovic, Frits van Rhee, Bridget Austin, Joshua D. Brandstadter, David C. Fajgenbaum   +12 more
doaj   +1 more source

Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia

Journal of Infection in Developing Countries, 2019
Introduction: Immune response to genital Chlamydia trachomatis infection is involved in both immunity and pathology. The cytokine profile during infection has been implicated in the disease outcome, either resolution or severe sequelae.
Alessandra Bua, Sara Cannas, Stefania Zanetti, Paola Molicotti   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Distinct cytokine patterns in Occult Hepatitis C and Chronic Hepatitis C Virus Infection [PDF]

, 2011
Background & Aim: The immunopathogenesis of chronic hepatitis C virus (HCV) infection is a matter of great controversy. The imbalance of T-helper lymphocyte cell cytokine production was believed to play an important pathogenic role in ...
Azza Azza Abdel-Aziz, Mohamed Abd-elmaksoud, Mona Elhadidy, Nashwa Abousamra, Nasser Mousa, Yahia Gad   +5 more
core   +1 more source