Results 81 to 90 of about 1,857,465 (364)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A comparison of biofluid cytokine markers across platform technologies: Correspondence or divergence? [PDF]

, 2018
BACKGROUND: Quantification of biofluid cytokines is a rapidly growing area of translational research. However, comparability across the expanding number of available assay platforms for detection of the same proteins remains to be determined. We aimed to
Casaletto, KB, Fox, E, Fitch, R., Bettcher, B, J.C. Rojas, Kramer, J. H., J.H. Kramer, Karydas, A, E. Fox, Boxer, AL, F.M. Elahi, Bettcher, BM, Kramer, JH, Walters, S., Elahi, F. M., Fitch, R, Rojas, JC, A.M. Staffaroni, Karydas, A., Walters, S, Fox, E., Zetterberg, H, S. Walters, Zetterberg, Henrik,, A. Karydas, Staffaroni, AM, B.M. Bettcher, Rojas, J. C., R. Fitch, Bettcher, B., Boxer, A. L., Elahi, FM, Casaletto, K. B., H. Zetterberg, A.L. Boxer, Staffaroni, A. M., K.B. Casaletto   +36 more
core   +1 more source

Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation

Tzu Chi Medical Journal, 2020
Objective: Human interleukin-10 (IL-10) is a dimeric and pleiotropic cytokine that plays a crucial role in cellular immunoregulatory responses. As IL-10 binds to its receptors, IL-10Ra and IL-10Rb, it will suppress or induce the downstream cellular ...
Chun-Chun Chang, Cheng-Der Liu, Sheng-Feng Pan, Wei-Han Huang, Chih-Wen Peng, Hao-Jen Hsu   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

a regulated cytokine network balance

, 2019
Aim: Uncertainty about the safety of cell therapy continues to be a major challenge to the medical community. Inflammation and the associated immune response represent a major safety concern hampering the development of long-term clinical therapy.
El Taghdouini, Adib, van Grunsven, Lea A., Lagneaux, Laurence, Fayyad-Kazan, Hussein, Najar, Mehdi, Sokal, Etienne, Faour, Wissam H., Najmi, Mustapha, Toungouz, Michel, Raicevic, Gordana   +9 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Cytokine Regulation Networks in the Cancer Microenvironment

, 2009
During carcinoma formation, cancer cells release various cytokines and growth factors into their surroundings and recruit and reprogram many other types of cells in order to establish a tumor microenvironment.
許博欽;張文君;林鶴雄;張道遠;黃思誠, SHEU, BOR-CHING;CHANG, WEN-CHUN;LIN, HO -HSIUNG;CHANG, DAW-YUAN;HUANG, SU-CHENG   +1 more
core   +1 more source

Determinants of the relationship between cytokine production in pregnant women and their infants. [PDF]

, 2009
Exposure to environmental factors during fetal life and infancy is thought to play an important role in the early development of innate and adaptive immunity.
Supali, Taniawati, Ariawan, Iwan, Ariawan Iwan, Djuardi, Yenny, Yazdanbakhsh, Maria, Robbert G M Bredius, Rodrigues Laura C., Yazdanbakhsh Maria, Sartono Erliyani, Sartono, Erliyani, Erliyani Sartono, Bredius Robbert G. M., Yenny Djuardi, Wibowo, Heri, Heri Wibowo, Taniawati Supali, Djuardi Yenny, Laura C Rodrigues, Supali Taniawati, Rodrigues, Laura C, Wibowo Heri, Iwan Ariawan, Bredius, Robbert GM, Maria Yazdanbakhsh   +23 more
core   +1 more source

Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli

, 2023
Background: Describing the kinetics of cytokines involved as biomarkers of sepsis progression could help to optimise interventions in septic patients. This work aimed to quantitively characterise the cytokine kinetics upon exposure to live E.
Lipcsey, Miklós, Hanslin, Katja,, Salma M. Bahnasawy, Friberg, Lena, Friberg, Lena,, Lipcsey, Miklós,, Nielsen, Elisabet I.,, Hanslin, Katja, Elisabet I. Nielsen, Nielsen, Elisabet I., Skorup, Paul, Katja Hanslin, Bahnasawy, Salma M., Bahnasawy, Salma M.,, Lena E. Friberg, Miklós Lipcsey, Paul Skorup, Skorup, Paul,   +17 more
core   +1 more source

Extraordinary effects of unnatural pairings

eLife, 2017
Engineered molecules based on human cytokines have potential uses in research and medicine.
Alejandro Villarino, John J O'Shea
doaj   +1 more source