Results 81 to 90 of about 1,176,895 (316)

Determinants of the relationship between cytokine production in pregnant women and their infants. [PDF]

, 2009
Exposure to environmental factors during fetal life and infancy is thought to play an important role in the early development of innate and adaptive immunity.
Supali, Taniawati, Ariawan, Iwan, Ariawan Iwan, Djuardi, Yenny, Yazdanbakhsh, Maria, Robbert G M Bredius, Rodrigues Laura C., Yazdanbakhsh Maria, Sartono Erliyani, Sartono, Erliyani, Erliyani Sartono, Bredius Robbert G. M., Yenny Djuardi, Wibowo, Heri, Heri Wibowo, Taniawati Supali, Djuardi Yenny, Laura C Rodrigues, Supali Taniawati, Rodrigues, Laura C, Wibowo Heri, Iwan Ariawan, Bredius, Robbert GM, Maria Yazdanbakhsh   +23 more
core   +2 more sources

Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli

, 2023
Background: Describing the kinetics of cytokines involved as biomarkers of sepsis progression could help to optimise interventions in septic patients. This work aimed to quantitively characterise the cytokine kinetics upon exposure to live E.
Lipcsey, Miklós, Hanslin, Katja,, Salma M. Bahnasawy, Friberg, Lena, Friberg, Lena,, Lipcsey, Miklós,, Nielsen, Elisabet I.,, Hanslin, Katja, Elisabet I. Nielsen, Nielsen, Elisabet I., Skorup, Paul, Katja Hanslin, Bahnasawy, Salma M., Bahnasawy, Salma M.,, Lena E. Friberg, Miklós Lipcsey, Paul Skorup, Skorup, Paul,   +17 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Effects of a diabetes-like environment in vitro on cytokine production by mouse splenocytes

, 2008
Elevated levels of glucose and free fatty acids as well as changes in the cytokine production are common features of both type 1 and type 2 diabetes. Especially regarding type 1 diabetes, immunological factors are believed to be responsible for much of ...
Sandler, Stellan,, Thorvaldson, Lina,, Stålhammar, Stefan,   +2 more
core   +1 more source

Extraordinary effects of unnatural pairings

eLife, 2017
Engineered molecules based on human cytokines have potential uses in research and medicine.
Alejandro Villarino, John J O'Shea
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Increase in Vascular Endothelial Growth Factor (VEGF) Expression and the Pathogenesis of iMCD-TAFRO

Biomedicines
TAFRO (thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (F/R), renal failure (R), and organomegaly (O)) is a heterogeneous clinical subtype of idiopathic multicentric Castleman disease (iMCD) associated with a significantly poorer ...
Gordan Srkalovic, Sally Nijim, Maya Blanka Srkalovic, David Fajgenbaum   +3 more
doaj   +1 more source

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

eLife, 2017
Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation.
Ignacio Moraga, Jamie B Spangler, Juan L Mendoza, Milica Gakovic, Tom S Wehrman, Peter Krutzik, K Christopher Garcia   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Moléculas de adhesión endotelial y fallo multiorgánico en pacientes con sepsis grave

, 2016
Mortality rates for patients with severe sepsis and septic shock range from 40% to 60%, costing the United States health care system approximately $17 billion annually [1].
Habib, Sheila A., Amalakuhan, Bravein, Mangat, Mandeep, Reyes, Luis F.   +3 more
core   +1 more source