Results 101 to 110 of about 1,857,465 (364)

Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia

Journal of Infection in Developing Countries, 2019
Introduction: Immune response to genital Chlamydia trachomatis infection is involved in both immunity and pathology. The cytokine profile during infection has been implicated in the disease outcome, either resolution or severe sequelae.
Alessandra Bua, Sara Cannas, Stefania Zanetti, Paola Molicotti   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Cytokine Storm in COVID-19—Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper

Frontiers in Immunology, 2020
Cytokine storm is an acute hyperinflammatory response that may be responsible for critical illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure.
S. Bhaskar, A. Sinha, Maciej Banach, S. Mittoo, Robert Weissert, J. Kass, Santhosh K. Rajagopal, Anupama R Pai, S. Kutty   +8 more
semanticscholar   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Effects of a diabetes-like environment in vitro on cytokine production by mouse splenocytes

, 2008
Elevated levels of glucose and free fatty acids as well as changes in the cytokine production are common features of both type 1 and type 2 diabetes. Especially regarding type 1 diabetes, immunological factors are believed to be responsible for much of ...
Sandler, Stellan,, Thorvaldson, Lina,, Stålhammar, Stefan,   +2 more
core   +1 more source

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

Cytokine & growth factor reviews, 2020
The outbreak of the novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) responsible for coronavirus disease 2019 (COVID-19) has developed into a major health hazard across the globe.
S. Nile, A. Nile, Jia-yin Qiu, Lin Li, Xu Jia, Guoyin Kai   +5 more
semanticscholar   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Th1 and Th2 cytokine immunomodulation by gangliosides in experimental autoimmune encephalomyelitis

, 2015
In experimental autoimmune encephalomyelitis, a classical model for multiple sclerosis, the cytokines provide the necessary signals to activate specific T cells for self-antigens.
Ashimine, R, de Castro, GM, Zollner, RD, Zanin, ME, Vilella, CA, Ventura-Oliveira, D   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Down-regulation of specific antigen-driven cytokine production in a population with endemic Schistosoma japonicum infection.

, 2002
Schistosome antigen-driven cytokine responses and antischistosome antibody levels of residents of a Schistosoma japonicum endemic island in Poyang Lake, Jiangxi Province were studied before and 45 days after treatment with praziquantel. IL-4, IL-5, IL-10
Z W XIE, C SU, M J JI, Zhang, ZS, L SHEN, Hu, LS, Su, C, Taylor, MG, Xie, ZW, R E WEIR, Ji, MJ, Q D BICKLE, L S HU, H W WU, S N COUSENS, Cousens, SN, Weir, RE, Shen, L, G L WU, Zhang, Y, Wu, GL, Bickle, QD, Z S ZHANG, Wu, HW, Chen, SZ, M G TAYLOR, S Z CHEN, Y ZHANG   +27 more
core   +1 more source