Results 91 to 100 of about 1,857,465 (364)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Moléculas de adhesión endotelial y fallo multiorgánico en pacientes con sepsis grave
, 2016 Mortality rates for patients with severe sepsis and septic shock range from 40% to 60%, costing the United States health care system approximately $17 billion annually [1].
Habib, Sheila A. +3 more
core +1 more source
eLife, 2017 Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation.
Ignacio Moraga +6 more
doaj +1 more source
Cytokine storm induced by SARS-CoV-2
Clinica chimica acta; international journal of clinical chemistry, 2020 Highlights • Dysregulated and excessive cytokine storm is vital for critical COVID-19 patients.• Mechanisms of SARS-CoV-2-infected included ACE2 mediated and other pathway response.• Infected lung epithelial cells and macrophages mainly release cytokines
Peipei Song +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Increase in Vascular Endothelial Growth Factor (VEGF) Expression and the Pathogenesis of iMCD-TAFRO
BiomedicinesTAFRO (thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (F/R), renal failure (R), and organomegaly (O)) is a heterogeneous clinical subtype of idiopathic multicentric Castleman disease (iMCD) associated with a significantly poorer ...
Gordan Srkalovic +3 more
doaj +1 more source
Cytokine storm intervention in the early stages of COVID-19 pneumonia
Cytokine & growth factor reviews, 2020 Highlights • COVID-19 infection can lead to the development of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome MODS within a few days of disease onset.• A powerful cytokine storm accompanies COVID-19 pneumonia.• The
Xin-Juan Sun +11 more
semanticscholar +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
, 2007 We have investigated phosphatidylinositol 3-kinase (PI3K)-dependent survival signalling pathways using several cytokines in three different hemopoietic cell lines, MC/9, FDC-P1, and TF-1. Cytokines caused PI3K- and PKB-dependent phosphorylation of FOXO3a
core +1 more source
Breast-implant associated unicentric castleman disease: a case report
Current Problems in Cancer: Case ReportsALK-negative anaplastic large cell lymphoma is a well-established hematologic complication of prosthetic breast implantation, but other rare conditions should also be considered.
Saishravan Shyamsundar +12 more
doaj +1 more source