Results 91 to 100 of about 1,176,895 (316)

Association between preoperative inflammatory biomarkers and postoperative morbidity and mortality in stage I–III colorectal cancer patients: a single-centre prospective study

BMJ Surgery, Interventions, & Health Technologies
Objective To investigate whether preoperative inflammatory biomarkers have prognostic value in terms of postoperative surgical morbidity in stage I–III resectable colorectal cancer.Design Prospective observational cohort study.Setting This is a single ...
Meriem Fella Guerni, Lilya Khelifi, Hakim Chatter, Meriem Mokhbi, Fetoma El Metennani, Kaouther Boughezala, Manel Amri, Imene Soufli, Houda Belguendouz, Rania Sihem Boussa, Chafia Touil-boukoffa, Batoul Latreche, Nassim Sid Idris   +12 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Effect of nutrient deficiencies on in vitro Th1 and Th2 cytokine response of peripheral blood mononuclear cells to Plasmodium falciparum infection. [PDF]

, 2010
BACKGROUND: An appropriate balance between pro-inflammatory and anti-inflammatory cytokines that mediate innate and adaptive immune responses is required for effective protection against human malaria and to avoid immunopathology.
Veenemans, J., Chilongola, Jaffu O, Veenemans, Jacobien, Meijerink, M., Mbugi Erasto V, Huub FJ Savelkoul, Shao John F, Meijerink Marjolein, Savelkoul, H.F.J., Savelkoul, Huub FJ, Hans Verhoef, Matthew McCall, Jaffu O Chilongola, Olomi, Raimos M, McCall Matthew, Raimos M Olomi, Veenemans Jacobien, Shao, J.F., Mbugi, Erasto V, McCall, Matthew, Jeurink, P.V., McCall, M., Verhoef, H., Marjolein Meijerink, Verhoef Hans, Savelkoul, H.F., Chilongola Jaffu O, Erasto V Mbugi, Savelkoul Huub FJ, Chilongola, J.O., John F Shao, Jeurink, Prescilla V, Shao, John F, Olomi, R.M., Jeurink Prescilla V, Mbugi, E.V., Jacobien Veenemans, Verhoef, Hans, Chilongola, J., Meijerink, Marjolein, Olomi Raimos M, Prescilla V Jeurink   +41 more
core   +1 more source

Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia

Journal of Infection in Developing Countries, 2019
Introduction: Immune response to genital Chlamydia trachomatis infection is involved in both immunity and pathology. The cytokine profile during infection has been implicated in the disease outcome, either resolution or severe sequelae.
Alessandra Bua, Sara Cannas, Stefania Zanetti, Paola Molicotti   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cytokine Regulation Networks in the Cancer Microenvironment

, 2009
During carcinoma formation, cancer cells release various cytokines and growth factors into their surroundings and recruit and reprogram many other types of cells in order to establish a tumor microenvironment.
許博欽;張文君;林鶴雄;張道遠;黃思誠, SHEU, BOR-CHING;CHANG, WEN-CHUN;LIN, HO -HSIUNG;CHANG, DAW-YUAN;HUANG, SU-CHENG   +1 more
core   +1 more source

Breast-implant associated unicentric castleman disease: a case report

Current Problems in Cancer: Case Reports
ALK-negative anaplastic large cell lymphoma is a well-established hematologic complication of prosthetic breast implantation, but other rare conditions should also be considered.
Saishravan Shyamsundar, Mateo Sarmiento Bustamante, Larissa Borys, Megan S. Lim, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Gordan Srkalovic, Frits van Rhee, Bridget Austin, Joshua D. Brandstadter, David C. Fajgenbaum   +12 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Down-regulation of specific antigen-driven cytokine production in a population with endemic Schistosoma japonicum infection.

, 2002
Schistosome antigen-driven cytokine responses and antischistosome antibody levels of residents of a Schistosoma japonicum endemic island in Poyang Lake, Jiangxi Province were studied before and 45 days after treatment with praziquantel. IL-4, IL-5, IL-10
Z W XIE, C SU, M J JI, Zhang, ZS, L SHEN, Hu, LS, Su, C, Taylor, MG, Xie, ZW, R E WEIR, Ji, MJ, Q D BICKLE, L S HU, H W WU, S N COUSENS, Cousens, SN, Weir, RE, Shen, L, G L WU, Zhang, Y, Wu, GL, Bickle, QD, Z S ZHANG, Wu, HW, Chen, SZ, M G TAYLOR, S Z CHEN, Y ZHANG   +27 more
core   +1 more source