Results 141 to 150 of about 5,332,469 (256)

Both cyclooxygenase- and cytokine-mediated inflammation are associated with carotid intima-media thickness

, 2007
BACKGROUND: Common carotid artery intima-media thickness (CCA-IMT) is a valid index of atherosclerosis, which is viewed as an inflammatory disease.
Basu, Samar,, Wohlin, Martin,, Larsson, Anders,, Lind, Lars,, Helmersson, Johanna,, Arnlöv, Johan,, Andrén, Bertil,, Sundström, Johan,, Vessby, Bengt,   +8 more
core   +1 more source

Rewiring tumor cytokine networks to enhance immune checkpoint blockade: mechanisms, engineering, and clinical translation

Journal of Experimental & Clinical Cancer Research
Immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 and CTLA-4 can produce durable remissions in multiple solid tumors, yet primary and acquired resistance remain frequent, often sustained by an immunosuppressive tumor microenvironment (TME ...
Xiaodong Wang, Junjie Wang, Qianqian Wang, Gouping Ding, Yiping Huang, Yeqian Feng   +5 more
doaj   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

An evaluation of cytokine-capture nanoparticle technology : stepping from bench-space into potential markets

, 2004
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2004.Includes bibliographical references (leaves 65-66).The feasibility of bringing a nascent technology for detection and quantification of local ...
Hong, Julee Y. (Julee Yang-A.), 1980-
core  

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

Cytokine-capture nanoparticles to quantify IL-2 concentrations within the immunological synapse during T cell activation

, 2003
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2003.Includes bibliographical references (leaf 29).The feasibility of bringing a nascent technology for detection and quantification of local cytokine ...
Hong, Julee Y. (Julee Yang-A.), 1980-
core  

a regulated cytokine network balance

, 2019
Aim: Uncertainty about the safety of cell therapy continues to be a major challenge to the medical community. Inflammation and the associated immune response represent a major safety concern hampering the development of long-term clinical therapy.
El Taghdouini, Adib, van Grunsven, Lea A., Lagneaux, Laurence, Fayyad-Kazan, Hussein, Najar, Mehdi, Sokal, Etienne, Faour, Wissam H., Najmi, Mustapha, Toungouz, Michel, Raicevic, Gordana   +9 more
core   +1 more source

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

Engineering cytokine secretion from Trypanosoma cruzi

Memorias do Instituto Oswaldo Cruz, 1994
A. C. La Flamme, F. Buckner, J. Swindle, J. Ajioka, L. Barrett, W. C. Van Voorhis   +5 more
doaj   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source