Results 101 to 110 of about 5,759,209 (333)

SUPPRESSOR OF CYTOKINE SIGNALING MEMBERS IN LUNG ADENOCARCINOMA: UNVEILING EXPRESSION PATTERNS, POSTTRANSLATIONAL MODIFICATIONS, AND CLINICAL SIGNIFICANCE

, 2023
Martínez Castro Jesús Alberto, Tat’y Mwata-Velu, Hubert Misonia, Mpangi Musungu Erick, Ayesha Qasim, Fida Ullah, Muhammad Tayyab Zamir, Miele Mboma Joachim, Juan Gabriel Avina‐Cervantes, Zahid Ullah, Sunga Baruti Jacob   +10 more
openalex   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Herbal Immunostimulants and Their Phytochemicals: Exploring Morinda citrifolia, Echinacea purpurea, and Phyllanthus niruri

Plants
The rising prevalence of infectious diseases and immune-related disorders underscores the need for effective and accessible therapeutic solutions. Herbal immunostimulants derived from medicinal plants offer promising alternatives, enhancing immune ...
Trivadila Trivadila, Dyah Iswantini, Min Rahminiwati, Mohamad Rafi, Adisa Putri Salsabila, Rut Novalia Rahmawati Sianipar, Susi Indariani, Anggia Murni   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Upregulation of SOCS-1 by Nutlin-3 in acute myeloid leukemia cells but not in primary normal cells

Clinics, 2014
OBJECTIVE: It has been shown that SOCS-1 plays an important role in the proper control of cytokine/growth factor responses and acts as a tumor suppressor in acute myeloid leukemias.
Veronica Tisato, Alessia Norcio, Claudio Celeghini, Daniela Milani, Arianna Gonelli, Paola Secchiero   +5 more
doaj   +1 more source

Cytokines and JAK–STAT Signaling

Experimental Cell Research, 1999
Characterization of the ability of IFNs to induce immediate early genes led to the identification of the STAT (signal transducers and activators of transcription) signaling paradigm. STATs are activated at the receptor and then directly transduce signals to the nucleus.
openaire   +2 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Editorial: Understanding and targeting neuro-immune interactions within disease and inflammation

Frontiers in Immunology, 2023
Eric H. Chang, Eric H. Chang, Eric H. Chang, Daniela Carnevale, Daniela Carnevale, Sangeeta S. Chavan, Sangeeta S. Chavan, Sangeeta S. Chavan   +7 more
doaj   +1 more source

HOXA10 and HOXA11 in Human Endometrial Benign Disorders: Unraveling Molecular Pathways and Their Impact on Reproduction

Biomolecules
HOX genes, a family of conserved transcription factors, are critical for reproductive tract development and endometrial functionality. This review highlights the molecular underpinnings of HOXA10/HOXA11 in reproductive health and their dysregulation in ...
Lorin-Manuel Pîrlog, Andrada-Adelaida Pătrășcanu, Mara-Diana Ona, Andreea Cătană, Ioana Cristina Rotar   +4 more
doaj   +1 more source

Significance of expression of suppressor of cytokine signaling proteins: Suppressor of cytokine signaling-1, suppressor of cytokine signaling-2, and suppressor of cytokine signaling-3 in papillary thyroid cancer

Journal of Cancer Research and Therapeutics, 2017
Uncontrolled cytokine signal transduction largely associated with oncogene activation, can have disastrous biological consequences. The suppressor of cytokine signaling (SOCS) proteins represent one of the mechanisms by which this rampant signaling can be dissipated.
Toral Pundrik, Kobawala, Trupti I, Trivedi, Kinjal Kevin, Gajjar, Girish H, Patel, Nandita R, Ghosh   +4 more
openaire   +2 more sources