Results 11 to 20 of about 5,759,209 (333)

Editorial: Cytokine signaling and innate host defense in modulation of viral infections and the viral evasion [PDF]

Frontiers in Cellular and Infection Microbiology
M. Victoria Delpino, Jorge Quarleri
doaj   +2 more sources

Suppressors of cytokine signaling 1 protein in a regenerative model of the Gekko japonicus spinal cord [PDF]

Journal of Integrative Neuroscience, 2021
Demyelination is one of the pathological outcomes that occur immediately following spinal cord injury. Protection of oligodendrocytes against death/apoptosis proves to be beneficial for the preservation of neurological functions.
Bingqiang He, Wenjuan Wang, Chunshuai Sun, Ting Yang, Hui Li, Xiaojun Chen, Hao Liang, Honghua Song, Yongjun Wang, Yingjie Wang   +9 more
doaj   +1 more source

Cytokine Signaling Process [PDF]

Definitions, 2020
openaire   +2 more sources

IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation

Frontiers in Immunology, 2022
Regulation of innate immune responses is essential for maintenance of immune homeostasis and development of an appropriate immunity against microbial infection.
Françoise Vuillier, Françoise Vuillier, Zhi Li, Zhi Li, Iain Black, Iain Black, Melania Cruciani, Melania Cruciani, Erminia Rubino, Erminia Rubino, Frédérique Michel, Frédérique Michel, Sandra Pellegrini, Sandra Pellegrini   +13 more
doaj   +1 more source

Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21

Frontiers in Genetics, 2021
Ubiquitin-specific peptidase 18 (USP18) acts as gatekeeper of type I interferon (IFN) responses by binding to the IFN receptor subunit IFNAR2 and preventing activation of the downstream JAK/STAT pathway.
Erminia Rubino, Erminia Rubino, Melania Cruciani, Nicolas Tchitchek, Nicolas Tchitchek, Anna Le Tortorec, Antoine D. Rolland, Önay Veli, Leslie Vallet, Giulia Gaggi, Frédérique Michel, Nathalie Dejucq-Rainsford, Sandra Pellegrini   +12 more
doaj   +1 more source

Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment

Frontiers in Immunology, 2021
BackgroundInterferon beta (IFNβ) has been prescribed as a first-line disease-modifying therapy for relapsing-remitting multiple sclerosis (RRMS) for nearly three decades.
Priyanka Devi-Marulkar, Priyanka Devi-Marulkar, Carolina Moraes-Cabe, Carolina Moraes-Cabe, Pascal Campagne, Béatrice Corre, Béatrice Corre, Aida Meghraoui-Kheddar, Aida Meghraoui-Kheddar, Vincent Bondet, Alba Llibre, Darragh Duffy, Elisabeth Maillart, Caroline Papeix, Sandra Pellegrini, Sandra Pellegrini, Frédérique Michel, Frédérique Michel   +17 more
doaj   +1 more source

Systematic Investigation of Cytokine Signaling Activity at the Tissue and Single-Cell Level

Nature Methods, 2021
Cytokines are critical for intercellular communication in human health and disease, but the investigation of cytokine signaling activity has remained challenging due to the short half-lives of cytokines and the complexity/redundancy of cytokine functions.
Peng Jiang, Yu Zhang, Beibei Ru, Yuan Yang, Trang Vu, Rohit Paul, A. Mirza, G. Altan-Bonnet, Lingrui Liu, E. Ruppin, L. Wakefield, K. Wucherpfennig   +11 more
semanticscholar   +1 more source

Engineered Cytokine Signaling to Improve CAR T Cell Effector Function

Frontiers in Immunology, 2021
Adoptive immunotherapy with T cells genetically modified to express chimeric antigen receptors (CARs) is a promising approach to improve outcomes for cancer patients.
M. Bell, S. Gottschalk
semanticscholar   +1 more source

Cytokine signaling: Cytokine-inducible signaling inhibitors [PDF]

Current Biology, 1997
Seven members of a family of cytokine-inducible proteins have been identified, a number of which have been shown to act as negative regulators of cytokine action. All of these proteins contain a central Src homology 2 domain, as well as conserved motifs in their carboxy-terminal regions.
Aman, M.Javad, Leonard, Warren J
openaire   +2 more sources

Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines via the mTOR/GSK-3β Axis

Frontiers in Immunology, 2021
In human primary dendritic cells (DC) rapamycin—an autophagy inducer and protein synthesis inhibitor—overcomes the autophagy block induced by Mycobacterium tuberculosis (Mtb) and promotes a Th1 response via IL-12 secretion.
Marilena P. Etna, Martina Severa, Valerio Licursi, Manuela Pardini, Melania Cruciani, Fabiana Rizzo, Elena Giacomini, Gianfranco Macchia, Orazio Palumbo, Raffaella Stallone, Massimo Carella, Mark Livingstone, Rodolfo Negri, Sandra Pellegrini, Eliana M. Coccia   +14 more
doaj   +1 more source