Results 31 to 40 of about 5,759,209 (333)
The molecular details of cytokine signaling via the JAK/STAT pathway
Protein Science, 2018 More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis, induce inflammation and control the immune response. Cytokines are secreted glycoproteins that act as intercellular messengers, inducing proliferation, differentiation ...
Rhiannon Morris, N. Kershaw, J. Babon
semanticscholar +1 more source
Extraordinary effects of unnatural pairings
eLife, 2017 Engineered molecules based on human cytokines have potential uses in research and medicine.
Alejandro Villarino, John J O'Shea
doaj +1 more source
eLife, 2017 Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation.
Ignacio Moraga +6 more
doaj +1 more source
Antioxidants, 2020 The chronic activation of the Janus kinase/signal transducer and activator of the transcription (JAK/STAT) pathway is linked to oxidative stress, inflammation and cell proliferation.
Sara La Manna +7 more
doaj +1 more source
Frontiers in Immunology, 2020 Cytokines are small signaling proteins that have central roles in inflammation and cell survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty cytokines have been identified. Amongst these is interleukin (IL)
R. Metcalfe +2 more
semanticscholar +1 more source
Retrovirus Entry by Endocytosis and Cathepsin Proteases
Advances in Virology, 2012 Retroviruses include infectious agents inducing severe diseases in humans and animals. In addition, retroviruses are widely used as tools to transfer genes of interest to target cells.
Yoshinao Kubo +4 more
doaj +1 more source
JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation
Frontiers in Immunology, 2019 Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from hematopoietic stem cells (HSCs) that differentiate through common ...
D. Gotthardt +3 more
semanticscholar +1 more source
Platelet regulation of myeloid suppressor of cytokine signaling 3 accelerates atherosclerosis
Science Translational Medicine, 2019 Platelet-induced myeloid Socs3 expression in humans and mice contributes to unresolved atherosclerosis inflammation and sustained plaque growth. Platelets and plaques Platelet activation promotes inflammation, and macrophage-platelet aggregates have been
Tessa J. Barrett +7 more
semanticscholar +1 more source
Frontiers in Immunology, 2019 SATB1 is a genome organizer protein that is expressed in a lineage specific manner in CD4+ T-cells. SATB1 plays a crucial role in expression of multiple genes throughout the thymic development and peripheral differentiation of T cells.
Satyajeet P. Khare +10 more
doaj +1 more source
Features of cytokine signaling forming T-helper immune response in COPD of varying severity
Russian Open Medical Journal, 2020 Introduction — Currently, chronic obstructive pulmonary disease (COPD) is a global public health problem. However, molecular mechanisms of the development of this pathology are still poorly understood.
Tatyana I. Vitkina +1 more
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