Results 41 to 50 of about 71,915 (261)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

No evidence for active viral infection in unicentric and idiopathic multicentric Castleman disease by Viral-Track analysis

Scientific Reports
Castleman disease (CD) is a rare hematologic disorder characterized by pathologic lymph node changes and a range of symptoms due to excessive cytokine production.
Ira Miller, Melanie D. Mumau, Saishravan Shyamsundar, Mateo Sarmiento Bustamante, Pedro Horna, Michael V. Gonzalez, David C. Fajgenbaum   +6 more
doaj   +1 more source

Immunomodulating Phytochemicals: An Insight Into Their Potential Use in Cytokine Storm Situations [PDF]

Advanced Pharmaceutical Bulletin
Phytochemicals are compounds found in plants that possess a variety of bioactive properties, including antioxidant and immunomodulatory properties. Recent studies have highlighted the potential of phytochemicals in targeting specific signalling pathways ...
Abdusalam Abdullah Alarabei, Nur Aimi Liyana Abd Aziz, Nur Izah AB Razak, Razif Abas, Hasnah Bahari, Maizaton Atmadini Abdullah, Mohd Khairi Hussain, Amin Malik Shah Abdul Majid, Rusliza Basir   +8 more
doaj   +1 more source

The Roles of Neutrophils in Cytokine Storms

Viruses, 2021
A cytokine storm is an abnormal discharge of soluble mediators following an inappropriate inflammatory response that leads to immunopathological events.
Lily Chan, Negar Karimi, Solmaz Morovati, Kasra Alizadeh, Julia E. Kakish, Sierra Vanderkamp, Fatemeh Fazel, Christina Napoleoni, Kimia Alizadeh, Yeganeh Mehrani, Jessica A. Minott, Byram W. Bridle, Khalil Karimi   +12 more
doaj   +1 more source

Plasmin regulation of acute cytokine storm [PDF]

Blood, 2017
In this issue of Blood , Shimazu et al report that cytokine release and activation is mediated through a previously unrecognized TLR9/plasmin/MMP9 axis ...
Jesus Maria, Gomez-Salinero, Shahin, Rafii   +1 more
openaire   +2 more sources

The cytokine storm and COVID‐19 [PDF]

Journal of Medical Virology, 2020
AbstractCoronavirus disease 2019 (COVID‐19), which began in Wuhan, China, in December 2019, has caused a large global pandemic and poses a serious threat to public health. More than 4 million cases of COVID‐19, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), have been confirmed as of 11 May 2020.
Hu, Biying, Huang, Shaoying, Yin, Lianghong   +2 more
openaire   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Common connective tissue disorder and anti-cytokine autoantibodies are enriched in idiopathic multicentric castleman disease patients

Frontiers in Immunology
IntroductionIdiopathic Multicentric Castleman Disease (iMCD) is a polyclonal lymphoproliferative disorder involving cytokine storms that can lead to organ failure and death.
Allan Feng, Allan Feng, Michael V. Gonzalez, Muge Kalaycioglu, Muge Kalaycioglu, Xihui Yin, Xihui Yin, Melanie Mumau, Saishravan Shyamsundar, Mateo Sarmiento Bustamante, Sarah E. Chang, Sarah E. Chang, Shaurya Dhingra, Shaurya Dhingra, Tea Dodig-Crnkovic, Jochen M. Schwenk, Tarun Garg, Kazuyuki Yoshizaki, Frits van Rhee, David C. Fajgenbaum, Paul J. Utz, Paul J. Utz   +21 more
doaj   +1 more source

Treatment Options during Cytokine Storm

Dr. Sulaiman Al Habib Medical Journal, 2021
Cytokine storm is the major cause of death in patients with acute respiratory distress caused by COVID-19. Because cytokine storm is a life-threatening condition, it is important to treat patients with the most appropriate drugs depending on their ...
Abdullah Alkattan, Kentaro Oh-hashi, Mahmoud Kandeel   +2 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source