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Criteria for Cytokine Storm Syndromes
In the past two decades, there has been a great deal of work aimed to devise diagnostic guidelines, classification criteria, and diagnostic scores for cytokine storm syndromes (CSSs). The most notable effort has been the large-scale multinational study that led to the development of the 2016 classification criteria for macrophage activation syndrome ...Francesca, Minoia, Angelo, Ravelli
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Criteria for Cytokine Storm Syndromes
2019In the past two decades, there has been a great deal of work aimed to devise diagnostic guidelines, classification criteria, and diagnostic scores for cytokine storm syndromes. The most notable effort has been the large-scale multinational study that led to the development of the 2016 classification criteria for macrophage activation syndrome (MAS ...
Francesca Minoia +3 more
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Clinical Features of Cytokine Storm Syndrome
2019Cytokine storm syndrome (CSS) is a severe life-threatening condition characterized by a clinical phenotype of overwhelming systemic inflammation, hyperferritinemia, hemodynamic instability, and multiple organ failure (MOF), and, if untreated, it can potentially lead to death.
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JAK Inhibitors in Cytokine Storm Syndromes
Cytokine storm syndromes (CSSs) comprise a group of severe and often fatal hyperinflammatory conditions driven by the overproduction of pro-inflammatory cytokines by activated cells of the immune system. Many of the CSS-associated cytokines mediate their downstream effects by signaling through the Janus kinases (JAKs) and signal transducers and ...Camille, Keenan +3 more
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Cytokine Storm Syndrome as a Manifestation of Primary HIV Infection
2019HIV infection triggers an inflammatory response that manifests as acute retroviral syndrome (ARS) in most individuals infected by HIV. While this syndrome is usually self-limited, primary HIV infection sometimes triggers a fulminant inflammatory process consistent with cytokine storm syndrome (CSS).
Nathaniel, Erdmann, Sonya L, Heath
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Primary Immunodeficiencies and Cytokine Storm Syndromes
2019Primary immunodeficiency diseases (PIDs) are a diverse and growing category of more than 300 chronic disorders that share a susceptibility to infections. Whether the result of a genetic lesion that causes defective granule-dependent cytotoxicity, excessive lymphoproliferation, or an overwhelming infection representing a unique antigenic challenge, PIDs
David A. Hill, Neil Romberg
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Kawasaki Disease-Associated Cytokine Storm Syndrome
Kawasaki disease (KD) is a hyperinflammatory syndrome manifesting as an acute systemic vasculitis characterized by fever, nonsuppurative conjunctival injection, rash, oral mucositis, extremity changes, and cervical lymphadenopathy. KD predominantly affects young children and shares clinical features and immunobiology with other hyperinflammation ...Paul, Tsoukas, Rae S M, Yeung
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Murine Models of Secondary Cytokine Storm Syndromes
Hemophagocytic lymphohistiocytosis (HLH) comprises a broad spectrum of life-threatening cytokine storm syndromes, classified into primary (genetic) or secondary (acquired) HLH. The latter occurs in a variety of medical conditions, including infections, malignancies, autoimmune and autoinflammatory diseases, acquired immunodeficiency, and metabolic ...Ellen, Brisse +5 more
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Alternative Therapies for Cytokine Storm Syndromes
2019Cytokine storm syndromes (CSS) are a challenge for physicians, both due to their aggressive nature and the need for tailored treatment for each patient. While hematopoietic stem cell transplantation (HSCT) has changed the fate of primary hemophagocytic lymphohistiocytosis (HLH), and biologics of macrophage activation syndrome (MAS)/secondary HLH, there
ÖZEN, SEZA, ESENBOĞA, SALİHA
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Cytokines and metabolic syndrome: The perfect storm for arterial aging
Atherosclerosis, 2011N ...
RIZZA, STEFANO, FEDERICI, MASSIMO
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