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Cytokine storm syndrome (CSS), which is frequently fatal, has garnered increased attention with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions associated with multiorgan system failure can be lumped under the CSS umbrella, including familial hemophagocytic lymphohistiocytosis (HLH) and secondary HLH associated with ...
Randy Quentin Cron, W Winn Chatham
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Cytokine Storm Syndromes in Pediatric Patients
The Journal of Allergy and Clinical Immunology: In Practice, 2023Cytokine storm syndromes (CSS) represent a diverse group of disorders characterized by severe overactivation of the immune system. In the majority of patients, CSS arise from a combination of host factors, including genetic risk and predisposing conditions, and acute triggers such as infections.
Caroline Diorio +2 more
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Bacteria-Associated Cytokine Storm Syndrome
2019While viruses are considered the most common infectious triggers for cytokine storm syndromes (CSS), a growing list of bacterial pathogens, particularly intracellular organisms, have been frequently reported to be associated with this syndrome. Both familial and sporadic cases of CSS are often precipitated by acute infections.
Esraa M, Eloseily, Randy Q, Cron
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Etoposide Therapy of Cytokine Storm Syndromes
2019Etoposide has revolutionized the treatment of primary as well as secondary hemophagocytic lymphohistiocytosis (HLH), and it is, together with corticosteroids, the most widely used therapy for HLH. In the early 1980s, long-term survival in primary HLH was
Jan-Inge, Henter +1 more
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Cytokines in Cytokine Storm Syndrome
2019As the eponymous mediators of the cytokine storm syndrome, cytokines are a pleomorphic and diverse set of soluble molecules that activate or suppress immune functions in a wide variety of ways. The relevant cytokines for each CSS are likely a result of differing combinations of environmental triggers and host susceptibilities.
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Laboratory Features and Pathology of Cytokine Storm Syndromes
2019The laboratory diagnosis of cytokine storm syndromes (CSSs), i.e., hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS), is often challenging. The laboratory features using routinely available tests lack specificity, whereas confirmatory testing is available in only few laboratories in the United States.
Flavia G, Rosado, Purva, Gopal
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Cytokine storm syndrome in SARS-CoV-2: a review
Zeitschrift für Naturforschung C, 2021Abstract After wreaking havoc on a global level with a total of 5,488,825 confirmed cases and 349,095 deaths as of May 2020, severe acute respiratory syndrome coronavirus 2 is truly living up to the expectations of a 21st-century pandemic.
Braira Wahid +2 more
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