Results 81 to 90 of about 86,839 (276)

Cytokine Storm in COVID-19: An Overview, Mechanism, Treatment Strategies, and Stem Cell Therapy Perspective

Pharmaceutical Sciences and Research, 2020
Coronavirus disease 2019 (COVID-19) is the disease caused by the highly transmittable novel coronavirus (SARS-CoV-2) infections. The disease was found at the end of December 2019, in Wuhan, China, and quickly spread worldwide with a higher mortality rate
Nuriza Ulul Azmi, Meidi Utami Puteri, Donny Lukmanto   +2 more
doaj   +1 more source

Is butyrate a natural alternative to dexamethasone in the management of CoVID-19? [version 1; peer review: 2 approved]

F1000Research, 2021
Coronavirus disease 2019 (CoVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has affected more than 100 million lives. Severe CoVID-19 infection may lead to acute respiratory distress syndrome and death of the patient, and is associated ...
Nithin K. K, Prakash Patil, Satheesh Kumar Bhandary, Vikram Haridas, Suchetha Kumari N, Sarathkumar E, Praveenkumar Shetty   +6 more
doaj   +1 more source

Extracorporeal blood purification for sepsis [PDF]

, 2016
published_or_final_versio
Chan, DTM, Shum, HP, Yan, WW
core   +1 more source

IL-6 Blockade in Cytokine Storm Syndromes [PDF]

, 2019
Interleukin-6 (IL-6) is a pro-inflammatory cytokine elevated in cytokine storm syndromes, including hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS). It is also elevated in cytokine release syndrome (CRS) after immune activating cancer therapies such as chimeric antigen receptor (CAR) T-cells or bispecific T-cell ...
openaire   +2 more sources

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology [PDF]

, 2020
Combination immunotherapy (CIT) is currently applied as a treatment for different cancers and is proposed as a cure strategy for chronic viral infections. Whether such therapies are efficient during an acute infection remains elusive.
Akhmetzyanova, Ilseyar [u.v.m.], David, Paul David, Drabczyk-Pluta, Malgorzata, Gruber, Achim D., Honke, Nadine, Kershaw, Olivia, Knuschke, Torben, Megger, Dominik A., Pastille, Eva, Werner, Tanja   +9 more
core   +1 more source

CALM BEFORE THE STORM: COVID-19 AND CYTOKINE STORM SYNDROME [PDF]

Chest, 2020
SESSION TITLE: Medical Student/Resident Lung Pathology SESSION TYPE: Med Student/Res Case Rep Postr PRESENTED ON: October 18-21, 2020 INTRODUCTION: COVID-19 is responsible for a large pandemic worldwide Multiple cases have been reported of a hyperinflammatory immune response, similar to cytokine storm syndrome (CSS) usually seen in cancer patients ...
Chahal, Japjot, Habib, Gaston, Masuta, Pardeep, Manta, Dragos, Ramakrishna, Kartik   +4 more
europepmc   +3 more sources

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

A Human β-Defensin-Based Recombinant Protein DF₂-HSA Ameliorates Cytokine Storm

Cells
Cytokine storm is a critical driver of acute respiratory distress syndrome and multiple organ failure. Human β-defensin 2 (HBD-2) is the first inducible defensin discovered in human body.
Yibo Du, Zhuojun Yu, Weijin Sheng, Yi Li, Lei Hou, Yanbo Zheng, Xiujun Liu, Yongsu Zhen   +7 more
doaj   +1 more source

Nutraceutical Targeting of Inflammation-Modulating microRNAs in Severe Forms of COVID-19: A Novel Approach to Prevent the Cytokine Storm

Frontiers in Pharmacology, 2020
The coronavirus disease 2019 (COVID-19) pandemic has become the number one health problem worldwide. As of August 2020, it has affected more than 18 million humans and caused over 700,000 deaths worldwide.
Michel Desjarlais, Michel Desjarlais, Maëlle Wirth, Maëlle Wirth, Isabelle Lahaie, Pakiza Ruknudin, Pierre Hardy, Alain Rivard, Sylvain Chemtob, Sylvain Chemtob   +9 more
doaj   +1 more source