Results 81 to 90 of about 1,637,423 (248)

Macrophage Activation Led Acute Heart Failure Managed Successfully with Immunosuppression

Journal of Blood Medicine, 2021
Karan Seegobin,1 Muhamad Alhaj Moustafa,1 Umair Majeed,1 Jordan C Ray,2 Marwan Shaikh,1 Liuyan Jiang,3 Han W Tun1 1Department of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, 32224, USA; 2Departmentof Cardio-Oncology, Mayo Clinic ...
Seegobin K, Alhaj Moustafa M, Majeed U, Ray JC, Shaikh M, Jiang L, Tun HW   +6 more
doaj  

Treatment of Electrical Storm with Amiodarone in Brugada Syndrome- an Unexpected Protective Effect [PDF]

, 2013
We are reporting on a 53 year old man with proven Brugada syndrome and ICD implantation for resuscitation in context of polymorphic VT. After recurrent arrhythmia he was treated with Amiodarone.
Novak, J, Lambiase, PD
core  

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Immunomodulating Phytochemicals: An Insight Into Their Potential Use in Cytokine Storm Situations [PDF]

Advanced Pharmaceutical Bulletin
Phytochemicals are compounds found in plants that possess a variety of bioactive properties, including antioxidant and immunomodulatory properties. Recent studies have highlighted the potential of phytochemicals in targeting specific signalling pathways ...
Abdusalam Abdullah Alarabei, Nur Aimi Liyana Abd Aziz, Nur Izah AB Razak, Razif Abas, Hasnah Bahari, Maizaton Atmadini Abdullah, Mohd Khairi Hussain, Amin Malik Shah Abdul Majid, Rusliza Basir   +8 more
doaj   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Persistent Interleukin‐18 Fuels Expansion of CD38+HLA‐DR+CD8+ T Cells in Still Disease and Macrophage Activation Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani, Remco G. A. Erkens, Alejandra Bodelón, Tim R. Mocking, Marein T. M. Putmans, Freya M. C. H. Huijsmans, Lyanne J. P. M. Sijbers, Aafke M. De Ligt, Maurice J. H. Van Haaren, Rianne C. Scholman, Noël M. M. Dautzenberg, Joyce I. Meesters‐Ensing, Martina Rossano, Laura Porretti, Stefan Nierkens, Francesca S. Minoia, Sebastiaan J. Vastert, Jorg van Loosdregt   +17 more
wiley   +1 more source

Is COVID-19-associated cytokine storm distinct from non-COVID-19 secondary hemophagocytic lymphohistiocytosis?

, 2022
Cytokine storm is an umbrella term that describes an inflammatory syndrome characterized by elevated levels of circulating cytokines and hyperactivation of innate and/or adaptive immune cells.
Chi, Jeffrey, Liu, Johnson M
core   +2 more sources

Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications

Therapeutic Advances in Respiratory Disease, 2020
The lung is a key target of the cytokine storm that can be triggered by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for the widespread clinical syndrome known as coronavirus disease 2019 (COVID-19). Indeed, in some patients,
Corrado Pelaia, Caterina Tinello, Alessandro Vatrella, Giovambattista De Sarro, Girolamo Pelaia   +4 more
doaj   +1 more source

A combinational approach to restore cytokine balance and to inhibit virus growth may promote patient recovery in severe COVID-19 cases

, 2020
The COVID-19 pandemic has led to twin public health and economic crises around the world. Not only has it cost hundreds of thousands of lives but also severely impacted livelihoods and placed enormous strain on community healthcare and welfare services ...
Mahmud-Al-Rafat, Abdullah, Muktadir, Hasneen, Billah, Morsaline, Muktadir, Abdul, Khan, Imran, Karim, Mahbubul, Haque Asim, Muzammal, Majumder, Apurba, Taylor-Robinson, Andrew W., Mainul Ahasan, Mohammad   +9 more
core   +1 more source

Ultraefficiently Calming Cytokine Storm Using Ti3 C2 Tx MXene.

, 2022
During the global outbreak of COVID-19 pandemic, "cytokine storm" conditions are regarded as the fatal step resulting in most mortality. Hemoperfusion is widely used to remove cytokines from the blood of severely ill patients to prevent uncontrolled ...
Guan, J, Wang, G, Yao, H, Han, J, Guo, X, Yang, J, Wang, T, Tao, S, Sun, X, Wang, C, Zhou, L, Zhang, J   +11 more
core   +1 more source