Results 81 to 90 of about 1,823,964 (347)

The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

Mediators of Inflammation, 2014
Osteoarthritis (OA) is the most common chronic disease of human joints. The basis of pathologic changes involves all the tissues forming the joint; already, at an early stage, it has the nature of inflammation with varying degrees of severity.
Piotr Wojdasiewicz, Łukasz A Poniatowski, D. Szukiewicz   +2 more
semanticscholar   +1 more source

Soluble CD14 Induces Pro-inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-Like Synovial Cells via Toll-Like Receptor 4 [PDF]

, 2020
Y. Ichise, Jun Saegusa, Shino Tanaka-Natsui, I. Naka, Shinya Hayashi, Ryosuke Kuroda, Akio Morinobu   +6 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

NOS2/ARG1 axis and immune cell ratios as promising prognostic and predictive biomarkers for Cetuximab combined with chemotherapy in wt-KRAS human colorectal cancer

Frontiers in Immunology
BackgroundResistance to epidermal growth factor receptor monoclonal antibodies (anti-EGFR), such as cetuximab, remains a major therapeutic challenge. Growing evidence suggests that local tumor immune cells and systemic inflammation influence therapeutic ...
Djehane Houria Mataam, Assia Galleze, Sarra Benkhelifa, Ryad Trari, Wafa Khelaifia, Said Belhadef, Sabrina Bouhara, Sonia Ait Younes, Anissa Benali, Hassan Mahfouf, Olivier Morales, Olivier Morales, Houda Belguendouz, Nadira Delhem, Chafia Touil-Boukoffa, Hayet Rafa, Hayet Rafa   +16 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Inflammasome signaling and regulation of interleukin-1 family cytokines

Journal of Experimental Medicine, 2019
Specific IL-1 family cytokines are initially expressed as inactive, cytosolic pro-forms. Chan and Schroder review inflammasome signaling and cell death decisions, mechanisms underpinning IL-1α, IL-1β, IL-18, and IL-37 maturation and release, and the ...
A. Chan, K. Schroder
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Comparative Analysis of Genetically Engineered Immunodeficient Mouse Strains as Recipients for Human Myoblast Transplantation

Cell Transplantation, 2005
The development of an optimized animal model for the in vivo analysis of human muscle cells remains an important goal in the search of therapy for muscular dystrophy.
Suse D. Silva-Barbosa, Gillian S. Butler-Browne, James P. Di Santo, Vincent Mouly   +3 more
doaj   +1 more source

Schistosomiasis Burden and Its Association With Lower Measles Vaccine Responses in School Children From Rural Cameroon

Frontiers in Immunology, 2018
Background and Methods: Schistosomiasis is debilitating and reported to impair immune responsiveness of infected hosts. In Cameroon, mass drug administration (MDA) is used in schoolchildren to reduce transmission of S. haematobium and S. mansoni.
Justin Komguep Nono, Justin Komguep Nono, Justin Komguep Nono, Justin Komguep Nono, Severin Donald Kamdem, Severin Donald Kamdem, Severin Donald Kamdem, Palmer Masumbe Netongo, Smritee Dabee, Michael Schomaker, Alim Oumarou, Frank Brombacher, Frank Brombacher, Frank Brombacher, Frank Brombacher, Roger Moyou-Somo   +15 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source