Results 111 to 120 of about 73,794 (208)

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Emerging Mechanisms and Roles for Asymmetric Cytokinesis

, 2017
Cytokinesis completes cell division by physically separating the contents of the mother cell between the two daughter cells. This event requires the highly coordinated reorganization of the cytoskeleton within a precise window of time to ensure faithful ...
E. Morais-de-Sá, Osório, DS, D.S. Osório, Thieleke-Matos, C, C. Thieleke-Matos, Morais-de-Sá, E, Carvalho, AX, A.X. Carvalho   +7 more
core   +1 more source

Comparative Evaluation of Ethanolic Extracts Obtained From the Seeds of White and Black Açai Exhibit Antioxidant and Cytoprotective Activity In Vitro

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Açai seed extracts (black/white) showed antioxidant activity (black ∼30% stronger), no cytotoxicity or genotoxicity, and transient cytoprotection in normal and cancer cell lines. Black extract (200 µg/mL) inhibited colony formation without reducing cisplatin efficacy. Phenolic‐rich seed waste warrants further therapeutic study. ABSTRACT The açai fruit (
Luana França Calandrini de Azevedo, Estanislaw Tairowite Prestes Correa, Hemilly Casanova Gonçalves Soeiro, Oscar Vinícius Moraes dos Santos, Gustavo Henrique da Silva Lopes, Karina Motta Melo, Vinicius Silva de Carvalho, Andryo Orfi de Almada Vilhena, Jorge das Dores Rissino, Karen Albuquerque Dias da Costa, Alberdan da Silva Santos, Cleusa Yoshiko Nagamachi, Julio Cesar Pieczarka   +12 more
wiley   +1 more source

GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster.

PLoS Genetics, 2014
The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein has been described as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is also known as a potent oncogene, commonly amplified in several human tumors.
Stefano Sechi, Gianni Colotti, Giorgio Belloni, Vincenzo Mattei, Anna Frappaolo, Grazia D Raffa, Margaret T Fuller, Maria Grazia Giansanti   +7 more
doaj   +1 more source

Primary data for EPFL thesis "Metabolic regulation of cytokinesis in Schizosaccharomyces pombe"

All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects ...
Uysal Özdemir, Özge
core   +1 more source

Proteomic Signatures of Noise‐Induced Hearing Loss in the Mouse Cochlea

Cell Biology International, Volume 50, Issue 10, October 2026.
ABSTRACT Hearing loss affects over 1.5 billion people worldwide and has substantial social, educational, and economic consequences. Although genetic studies have identified numerous hearing‐loss‐associated genes, the molecular changes accompanying noise‐induced hearing loss (NIHL) remain incompletely understood.
Ana Carla Batissoco, Danillo Alencar‐Coutinho, Ana Carolina Ferreira‐Scatone, Stella Diogo‐Cavassana, Jeanne Oiticica, Karina Lezirovitz, Ricardo Ferreira Bento   +6 more
wiley   +1 more source

Examining the role of SNAREs in mammalian cytokinesis [PDF]

, 2008
Cytokinesis is the terminal step in cell division and likely requires membrane trafficking and fusion events. To investigate the possible role of soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptors (SNAREs) in mammalian ...
Nagar, Kaajal
core  

Klotho Exerts an Emerging Role in Cytokinesis

, 2020
The Klotho gene functions as an anti-aging gene. A previous klotho-knockout mice study indicated that neither male nor female gametocytes could accomplish the first meiotic division. It suggested that Klotho might regulate cell division.
Chiao-Yin Sun, Kang-Chieh Lo, Yan-Liang Liou, Chi-Yuan Chou, Yu-Ying Hsieh, Yau-Hung Chen   +5 more
core   +1 more source

Integrative Bioinformatics and Machine Learning Approaches for Biomarker and Pathway Discovery in Malignant Pleural Mesothelioma

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Malignant pleural mesothelioma (MPM) is a highly aggressive thoracic cancer with limited treatment options and poor prognosis. Aims This study employed an integrative transcriptomic and computational approach to uncover potential biomarkers for MPM.
Md. Lotifur Rohman, Suman Biswas
wiley   +1 more source

Effect of Phosphorylation on Dbf2 in Cytokinesis

, 2016
Cytokinesis is the physical process of cell division, which divides the cytoplasm between the two new daughter cells. One important pathway that regulates Cytokinesis is called the Mitotic Exit Network, or MEN for short. The MEN is signaling pathway that
Ayres, Alexander
core   +1 more source