Results 91 to 100 of about 57,995 (204)
Cytokinesis, as the last stage of the cell division cycle, is a tightly controlled process amongst all eukaryotes, with defective division leading to severe cellular consequences and implicated in serious human diseases and conditions such as cancer ...
Imane M. Rezig +2 more
doaj +1 more source
The Secret (Mitotic) Life of Clathrin
A perspective on the function of clathrin at the mitotic spindle during cell division. ABSTRACT The discovery of clathrin was a foundational event in membrane traffic research. Its identification as the major protein component of the coat that surrounds endocytic vesicles kickstarted the biochemical and molecular characterization of endocytosis. During
Stephen J. Royle
wiley +1 more source
The Roles of Septins in Regulating Fission Yeast Cytokinesis
Cytokinesis is required to separate two daughter cells at the end of mitosis, and septins play crucial roles in many aspects of cytokinesis. While septins have been intensively studied in many model organisms, including the budding yeast Saccharomyces ...
Shengnan Zheng, Biyu Zheng, Chuanhai Fu
doaj +1 more source
The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein has been described as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is also known as a potent oncogene, commonly amplified in several human tumors.
Stefano Sechi +7 more
doaj +1 more source
Mimicking Cellular Membranes With Micropatterned Lipid Bilayers
This Perspective spotlights micropatterning of as a key tool to model membrane systems which capture the complexities of cellular membranes, specifically of bacterial ones. Through precise manipulation of compositional heterogeneity, morphology, and topography in artificial bilayers, these synthetic membranes serve as in vitro analogs of cellular ...
Thuy An Nguyen, Zexi Xu, Petra Schwille
wiley +1 more source
Condensates on the Move: Midbody Remnants as Large, Translation‐Competent Extracellular Vesicles
Mitotic cells produce three EV types: exosomes and microvesicles (green/blue) delivering pre‐formed molecules, and midbody remnants (magenta) containing functional ribosomes and translation machinery within biomolecular condensates. Unlike passive cargo carriers, MBRs actively synthesize proteins after release, transforming from cellular debris to ...
Ahna R. Skop
wiley +1 more source
The power of many: when genetics met yeasts and high‐throughput
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley +1 more source
ABSTRACT Adipocyte hypertrophy poses an important mechanical challenge—adipocytes can increase in volume up to a thousand‐fold while still maintaining their structural integrity. Although lipid metabolism is well studied, little is known about the cytoskeletal adaptations that are required to accommodate this expansion and the resulting pathological ...
Dhakshmi Sasankan, Renu Mohan
wiley +1 more source
ABSTRACT Chondrosarcomas are malignant cartilage‐forming bone tumors with heterogeneous behavior, making prognostication and clinical management challenging. Histological grading is the primary tool for predicting clinical outcomes in conventional chondrosarcoma.
Sara Cardoso +15 more
wiley +1 more source

