Results 91 to 100 of about 73,794 (208)

The E‐cadherin‐Wnt‐mir‐994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance

Cell Proliferation, EarlyView.
In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu, Hiu Laam Yau, Runzhi Deng, Sarah E. Webb, Shiyuan Chen, Jianquan Ni, Ting Xie   +6 more
wiley   +1 more source

Regulation of the cytokinesis cleavage furrow by PKCε

, 2014
Cytokinesis is the final act of the cell cycle where the replicated DNA and cellular contents are finally split into two daughter cells. This process is very tightly controlled as DNA segregation errors and cytokinesis failure is commonly associated with
Pike, Tanya, Parker, Peter; id_orcid, Claus, Jeroen, Brownlow, Nicola, Crossland, Victoria   +4 more
core   +1 more source

Ploidy‐Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells

Cell Proliferation, EarlyView.
Using isogenic hESCs, differing only in their ploidy level, we show the effect of ploidy on the resistance to anticancer drugs. We demonstrate that polyploidy, by itself, confers sensitivity to chemotherapies, leading to higher apoptosis and delayed proliferation, while the loss of p53 reverses the phenotype, demonstrating higher resistance.
Guy Haim‐Abadi, Nissim Benvenisty
wiley   +1 more source

Rescue of pATOM36‐depleted T. brucei by human MTCH1/2 reveals common features of protein insertases

The FEBS Journal, EarlyView.
Human MTCH1 and MTCH2 (with an N‐terminal extension) functionally complement the loss of pATOM36 in T. brucei, indicating that these evolutionarily distant proteins recognize a common set of substrates and share fundamental principles of mitochondrial outer membrane protein insertion. Structural analyses reveal a common hydrophilic cavity, supporting a
Stephan Berger, Markus Daniel Gerber, Torsten Ochsenreiter, Christoph von Ballmoos, André Schneider   +4 more
wiley   +1 more source

Auxin response and PIN‐mediated transport in chlorophyte algae

Journal of Integrative Plant Biology, EarlyView.
Like multicellular plants, green algae respond to auxin and move it across their cells. However, their PIN‐like proteins do not act like plant auxin exporters, suggesting that basic auxin transport evolved early and specialized directional transport appeared later in plant evolution.
Adrijana Smoljan, Sarah Koutnik‐Abele, Dmitrii Vladimirtsev, Petr Klíma, Anita Bírošíková, Yuzhou Zhang, Jack Merrin, Maximilian Schuster, Katarina Kurtović, Ulrich Z. Hammes, Jan Petrášek, Jiří Friml   +11 more
wiley   +1 more source

Beyond single cells: Ten years of commercial lattice light‐sheet microscopy

Journal of Microscopy, EarlyView.
Abstract Lattice light‐sheet microscopy (LLSM) enables gentle, rapid, volumetric fluorescence imaging of living biological systems. The technique employs Bessel beam interference to produce a light‐sheet which retains its thickness over a relatively large field‐of‐view compared to other light‐sheets.
Helena L. E. Coker, David S. Corcoran
wiley   +1 more source

Subversion of plant endomembrane trafficking by a Plasmodiophora brassicae effector PbALE that recruits membrane components at the host–pathogen interface to aid in colonization

New Phytologist, EarlyView.
Schematics of ΔSPPbALE‐induced disruption of plant endomembrane trafficking impairs both preinvasive and postinvasive immunity against filamentous fungi and facilitates intracellular colonization by Plasmodiophora brassicae. Summary Plasmodiophora brassicae, an intracellular biotrophic protist that causes clubroot in crucifers, extensively alters the ...
Musharaf Hossain, Jiangying Tu, Yangdou Wei, Peta C. Bonham‐Smith, Christopher D. Todd   +4 more
wiley   +1 more source

A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth

Frontiers in Cell and Developmental Biology
While the structural organization and molecular biology of neurons are well characterized, the physical process of axonal elongation remains elusive. The classic view posited elongation occurs through the deposition of cytoskeletal elements in the growth
Erin M. Craig, Francesca Oprea, Sajid Alam, Ania Grodsky, Kyle E. Miller   +4 more
doaj   +1 more source

Cultivar‐Specific Production of Unreduced Pollen in the Ornamental Bigleaf Hydrangea (Hydrangea macrophylla ssp. macrophylla)

Plant Breeding, EarlyView.
ABSTRACT Unreduced gametes naturally promote polyploidization and are valuable in breeding polyploid offspring. Bigleaf hydrangea (Hydrangea macrophylla ssp. macrophylla), a major ornamental crop, has shown spontaneous polyploidization rates ranging from 0% to 94% in previous crosses.
Conny Tränkner, Anke Müller
wiley   +1 more source

Cytokinesis in animal cells.

, 2012
Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase spindle.
Green, R., Paluch, E., Oegema, K.
core