Results 1 to 10 of about 6,788 (129)

Central Role of the Actomyosin Ring in Coordinating Cytokinesis Steps in Budding Yeast [PDF]

Journal of Fungi
Eukaryotic cells must accurately transfer their genetic material and cellular components to their daughter cells. Initially, cells duplicate their chromosomes and subsequently segregate them toward the poles.
Magdalena Foltman, Alberto Sanchez-Diaz
doaj   +4 more sources

Spatiotemporal recruitment of RhoGTPase protein GRAF inhibits actomyosin ring constriction in Drosophila cellularization [PDF]

eLife, 2021
Actomyosin contractility is regulated by Rho-GTP in cell migration, cytokinesis and morphogenesis in embryo development. Whereas Rho activation by Rho-GTP exchange factor (GEF), RhoGEF2, is well known in actomyosin contractility during cytokinesis at the
Swati Sharma, Richa Rikhy
doaj   +2 more sources

Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels [PDF]

eLife, 2020
Cytokinesis, which enables the physical separation of daughter cells once mitosis has been completed, is executed in fungal and animal cells by a contractile actin- and myosin-based ring (CAR).
Elisa Gómez-Gil, Rebeca Martín-García, Jero Vicente-Soler, Alejandro Franco, Beatriz Vázquez-Marín, Francisco Prieto-Ruiz, Teresa Soto, Pilar Pérez, Marisa Madrid, Jose Cansado   +9 more
doaj   +2 more sources

Mechanical Ring Interfaces between Adherens Junction and Contractile Actomyosin to Coordinate Entotic Cell-in-Cell Formation

Cell Reports, 2020
Summary: Entosis is a cell-in-cell (CIC)-mediated death program. Contractile actomyosin (CA) and the adherens junction (AJ) are two core elements essential for entotic CIC formation, but the molecular structures interfacing them remain poorly understood.
Manna Wang, Zubiao Niu, Hongquan Qin, Banzhan Ruan, You Zheng, Xiangkai Ning, Songzhi Gu, Lihua Gao, Zhaolie Chen, Xiaoning Wang, Hongyan Huang, Li Ma, Qiang Sun   +12 more
doaj   +3 more sources

Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly [PDF]

Nature Communications, 2017
The fission yeast cytokinetic ring assembles by Search-Capture-Pull-Release from precursor nodes that include formin Cdc12 and myosin Myo2. The authors reconstitute Search-Capture-Pull in vitro and find that Myo2 pulling on Cdc12-associated actin ...
Dennis Zimmermann, Kaitlin E. Homa, Glen M. Hocky, Luther W. Pollard, Enrique M. De La Cruz, Gregory A. Voth, Kathleen M. Trybus, David R. Kovar   +7 more
doaj   +2 more sources

CHI3L1 promotes cell division through activation of RhoA in lung cancer cells [PDF]

Cell Communication and Signaling
Background Cytokinesis, the final stage of cell division, is crucial for maintaining genomic stability. Dysregulation of cytokinesis can contribute to cancer development. This study aimed to investigate the role of CHI3L1 in cytokinesis and its influence
Ji Eun Yu, Jung-Hyun Shim, In Jun Yeo, Dong Ju Son, Jaesuk Yun, Key-Hwan Lim, Hanseul Park, Yoon Seok Roh, Sang-Bae Han, Jin Tae Hong   +9 more
doaj   +2 more sources

Distinct actomyosin–septin coordination governs conidiation and septation in Verticillium dahliae [PDF]

mLife
Conidiation is the primary mode of reproduction in filamentous fungi and is essential for the dispersal of pathogenic species. However, the fundamental cellular mechanisms regulating conidiation in plant pathogenic fungi remain largely unexplored.
Juan Tian, Mengli Pu, Bin Chen, Xiaxia Zhang, Yanjun Yu, Chunli Li, Haiyun Wang, Zhaosheng Kong   +7 more
doaj   +2 more sources

Myosin cluster dynamics determines epithelial wound ring constriction [PDF]

iScience
Summary: Collection of myosin motors and actin filaments can self-assemble into submicrometric clusters under the regulation of RhoA. Emergent dynamics of these clusters have been reported in a variety of morphogenetic systems, ranging from Drosophila to
Alka Bhat, Rémi Berthoz, Simon Lo Vecchio, Coralie Spiegelhalter, Shigenobu Yonemura, Olivier Pertz, Daniel Riveline   +6 more
doaj   +2 more sources

Actomyosin dynamics in detached cells: linking clutch model to cell migration and cytokinesis [PDF]

BMC Molecular and Cell Biology
Summary Background Cortical retrograde flow of actomyosin plays a critical role in cell migration and cytokinesis. While such flows have been extensively studied in adherent cells, their underlying mechanisms in non-adherent conditions remain poorly ...
Shigehiko Yumura, Yumi Kikuta, Go Itoh
doaj   +2 more sources

Structure of the fission yeast actomyosin ring during constriction [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2018
Matthew T Swulius, Mark S Ladinsky, Davi R Ortega   +2 more
exaly   +2 more sources