Stabilization of the Actomyosin Ring Enables Spermatocyte Cytokinesis in Drosophila [PDF]
The scaffolding protein anillin is required for completion of cytokinesis. Anillin binds filamentous (F) actin, nonmuscle myosin II, and septins and in cell culture models has been shown to restrict actomyosin contractility to the cleavage furrow. Whether anillin also serves this function during the incomplete cytokinesis that occurs in developing germ
Goldbach, Philip +5 more
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Involvement of an Actomyosin Contractile Ring in Saccharomyces cerevisiae Cytokinesis [PDF]
In Saccharomyces cerevisiae, the mother cell and bud are connected by a narrow neck. The mechanism by which this neck is closed during cytokinesis has been unclear. Here we report on the role of a contractile actomyosin ring in this process. Myo1p (the only type II myosin in S.
E, Bi +6 more
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A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation [PDF]
The cytoskeleton is a major determinant of cell-shape changes that drive the formation of complex tissues during development. Important roles for actomyosin during tissue morphogenesis have been identified, but the role of the microtubule cytoskeleton is
Blanchard, Guy B. +3 more
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MPF governs the assembly and contraction of actomyosin rings by activating RhoA and MAPK during chemical-induced cytokinesis of goat oocytes. [PDF]
The interplay between maturation-promoting factor (MPF), mitogen-activated protein kinase (MAPK) and Rho GTPase during actin-myosin interactions has yet to be determined.
Yan-Guang Wu +7 more
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Force Generation and Contraction of Random Actomyosin Rings [PDF]
Cytokinetic rings and stress fibers generate effective contraction, but how organized respective actomyosin arrays are, and how semi-random actomyosin bundles generate contraction is not clear.We investigate computationally the self-organization and contraction of an actomyosin ring that is completely disorganized initially. To this end, we formulate a
Oelz, Dietmar B. +2 more
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Actomyosin Rings: The Riddle of the Sphincter [PDF]
Contractile rings consisting of actin filaments and myosin-2 have long been known to power cytokinesis, but recent work has shown that single-cell and multicellular actomyosin rings participate in processes ranging from wound healing to extrusion of apoptotic cells from epithelia.
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Author response image 1. Actomyosin ring closure dynamics. [PDF]
Cytokinesis in eukaryotic cells is often accompanied by actomyosin cortical flow. Over 30 years ago, Borisy and White proposed that cortical flow converging upon the cell equator compresses the actomyosin network to mechanically align actin filaments ...
Erzberger, Anna +14 more
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Cortical flow aligns actin filaments to form a furrow
Cytokinesis in eukaryotic cells is often accompanied by actomyosin cortical flow. Over 30 years ago, Borisy and White proposed that cortical flow converging upon the cell equator compresses the actomyosin network to mechanically align actin filaments ...
Anne-Cecile Reymann +4 more
doaj +1 more source
Cell polarity protein Spa2 coordinates Chs2 incorporation at the division site in budding yeast. [PDF]
Deposition of additional plasma membrane and cargoes during cytokinesis in eukaryotic cells must be coordinated with actomyosin ring contraction, plasma membrane ingression and extracellular matrix remodelling.
Magdalena Foltman +3 more
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Summary: Animal cell cytokinesis requires activation of the GTPase RhoA (Rho1 in Drosophila), which assembles an F-actin- and myosin II-dependent contractile ring (CR) at the equatorial plasma membrane.
Sabrya C. Carim, Gilles R.X. Hickson
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