Actin–Microtubule Crosstalk Imparts Stiffness to the Contractile Ring in Fission Yeast [PDF]
Cells, 2023 Actin–microtubule interactions are critical for cell division, yet how these networks of polymers mutually influence their mechanical properties and functions in live cells remains unknown.
Kimberly Bellingham-Johnstun +4 more
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The Ringleaders: Understanding the Apicomplexan Basal Complex Through Comparison to Established Contractile Ring Systems [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 The actomyosin contractile ring is a key feature of eukaryotic cytokinesis, conserved across many eukaryotic kingdoms. Recent research into the cell biology of the divergent eukaryotic clade Apicomplexa has revealed a contractile ring structure required ...
Alexander A. Morano +3 more
doaj +4 more sources
Nanoscale architecture of the Schizosaccharomyces pombe contractile ring [PDF]
eLife, 2017 The contractile ring is a complex molecular apparatus which physically divides many eukaryotic cells. Despite knowledge of its protein composition, the molecular architecture of the ring is not known.
Nathan A McDonald +4 more
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Processes Controlling the Contractile Ring during Cytokinesis in Fission Yeast, Including the Role of ESCRT Proteins [PDF]
Journal of FungiCytokinesis, as the last stage of the cell division cycle, is a tightly controlled process amongst all eukaryotes, with defective division leading to severe cellular consequences and implicated in serious human diseases and conditions such as cancer ...
Imane M. Rezig +2 more
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Mechanisms of contractile ring tension production and constriction [PDF]
Biophysical Reviews, 2018 The contractile ring is a remarkable tension-generating cellular machine that constricts and divides cells into two during cytokinesis, the final stage of the cell cycle. Since the ring's discovery, the parallels with muscle have been emphasized. Both are contractile actomyosin machineries, and long ago, a muscle-like sliding filament mechanism was ...
Sathish Thiyagarajan +1 more
exaly +5 more sources
Cytokinetic contractile ring structural progression in an early embryo: positioning of scaffolding proteins, recruitment of α-actinin, and effects of myosin II inhibition [PDF]
Frontiers in Cell and Developmental BiologyOur knowledge of the assembly and dynamics of the cytokinetic contractile ring (CR) in animal cells remains incomplete. We have previously used super-resolution light microscopy and platinum replica electron microscopy to elucidate the ultrastructural ...
John H. Henson +19 more
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Measurement of Contractile Ring Tension Using Two-photon Laser Ablation during Drosophila Cellularization [PDF]
Bio-Protocol, 2022 Cytokinesis occurs at the final step of cell division and leads to the separation of daughter cells. It requires assembly and constriction of the actomyosin contractile ring.
Swati Sharma, Richa Rikhy
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Contractile ring mechanosensation and its anillin-dependent tuning during early embryogenesis [PDF]
Nature Communications, 2023 Cytokinesis plays crucial roles in morphogenesis. Previous studies have examined how tissue mechanics influences the position and closure direction of the contractile ring.
Christina Rou Hsu +4 more
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Contractile ring composition dictates kinetics of in silico contractility. [PDF]
Biophys J, 2023 Constriction kinetics of the cytokinetic ring are expected to depend on dynamic adjustment of contractile ring composition, but the impact of ring component abundance dynamics on ring constriction is understudied. Computational models generally assume that contractile networks maintain constant total amounts of components, which is not always true.
Cortes DB +3 more
europepmc +3 more sources
The Mechanosensitive Pkd2 Channel Modulates the Recruitment of Myosin II and Actin to the Cytokinetic Contractile Ring [PDF]
Journal of FungiCytokinesis, the last step in cell division, separates daughter cells through mechanical force. This is often through the force produced by an actomyosin contractile ring.
Pritha Chowdhury +4 more
doaj +2 more sources