Results 11 to 20 of about 75,941 (270)
Nanoscale architecture of the Schizosaccharomyces pombe contractile ring [PDF]
eLife, 2017 The contractile ring is a complex molecular apparatus which physically divides many eukaryotic cells. Despite knowledge of its protein composition, the molecular architecture of the ring is not known.
Nathan A McDonald +4 more
doaj +4 more sources
Mechanisms of contractile ring tension production and constriction [PDF]
Biophysical Reviews, 2018 The contractile ring is a remarkable tension-generating cellular machine that constricts and divides cells into two during cytokinesis, the final stage of the cell cycle. Since the ring's discovery, the parallels with muscle have been emphasized. Both are contractile actomyosin machineries, and long ago, a muscle-like sliding filament mechanism was ...
Ben O'Shaughnessy +1 more
exaly +5 more sources
Molecular model of the contractile ring [PDF]
Physical Review Letters, 2005 We present a model for the actin contractile ring of adherent animal cells. The model suggests that the actin concentration within the ring and consequently the power that the ring exerts both increase during contraction.
Tlusty, T +3 more
core +5 more sources
Redistribution of actin during assembly and reassembly of the contractile ring in grasshopper spermatocytes. [PDF]
PLoS ONE, 2009 Cytokinesis in animal cells requires the assembly of an actomyosin contractile ring to cleave the cell. The ring is highly dynamic; it assembles and disassembles during each cell cleavage, resulting in the recurrent redistribution of actin.
G Bradley Alsop +4 more
doaj +2 more sources
Cell Reports, 2014 Cdc15p is known to contribute to cytokinesis in fission yeast; however, the protein is not required to assemble the contractile ring of actin and myosin, but it helps to anchor the ring to the plasma membrane.
Rajesh Arasada, Thomas D. Pollard
doaj +2 more sources
Physical Model of Contractile Ring Initiation in Dividing Cells [PDF]
Biophysical Journal, 2008 We present a physical mechanism to describe initiation of the contractile ring during cell division. The model couples the membrane curvature with the contractile forces produced by protein clusters attached to the membrane.
Shlomovitz, Roie, Gov, Nir S.
core +3 more sources
Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly
Nature Communications, 2017 The fission yeast cytokinetic ring assembles by Search-Capture-Pull-Release from precursor nodes that include formin Cdc12 and myosin Myo2. The authors reconstitute Search-Capture-Pull in vitro and find that Myo2 pulling on Cdc12-associated actin ...
Dennis Zimmermann +7 more
doaj +2 more sources
Cell size sets the diameter of the budding yeast contractile ring [PDF]
Nature Communications, 2020 Budding yeast cell polarization is known to self-assemble, but it is still not clear what controls the size of the resulting septin ring. Here the authors show that the septin ring diameter is set by cell volume, ensuring that larger cells have larger ...
I. V. Kukhtevich +4 more
doaj +2 more sources
Mechanism of cytokinetic contractile ring constriction in fission yeast. [PDF]
Dev Cell, 2014 SummaryCytokinesis involves constriction of a contractile actomyosin ring. The mechanisms generating ring tension and setting the constriction rate remain unknown because the organization of the ring is poorly characterized, its tension was rarely ...
Stachowiak MR +6 more
europepmc +5 more sources
Mechanical power is maximized during contractile ring-like formation in a biomimetic dividing cell model [PDF]
Nature CommunicationsThe spatial and temporal dynamics of forces in cells coordinate essential behaviors like division, polarization, and migration. While intracellular signaling initiates contractile ring assembly during cell division, how mechanical forces coordinate ...
Ryota Sakamoto, Michael P. Murrell
doaj +2 more sources