The MO25 protein Pmo25 functions in contractile ring stability and Sid2 localization during cytokinesis [PDF]
iScienceSummary: Mouse protein-25 (MO25) family proteins are crucial in development and morphogenesis from plants to humans. The fission yeast MO25 protein Pmo25 is essential for cell polarity and division.
Yanfang Ye +6 more
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Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis [PDF]
Open Biology, 2013 Cytokinesis is a highly ordered cellular process driven by interactions between central spindle microtubules and the actomyosin contractile ring linked to the dynamic remodelling of the plasma membrane.
Tetsuya Takeda +6 more
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Curr Biol, 2011 What is the contractile ring? During cell division, the contractile ring generates the constricting force to separate one cell into two cells. Formed during cytokinesis, the last step of cell division, the contractile ring is composed of filamentous actin (F-actin) and the motor protein myosin-2, along with additional structural and regulatory proteins.
Miller AL.
europepmc +4 more sources
The Myosin-V Myo51 and Alpha-Actinin Ain1p Cooperate during Contractile Ring Assembly and Disassembly in Fission Yeast Cytokinesis [PDF]
Journal of FungiCytokinesis is driven in part by the constriction of a ring of actin filaments, myosin motors and other proteins. In fission yeast, three myosins contribute to cytokinesis including a Myosin-V Myo51.
Zoe L. Tyree +3 more
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Mechanisms of contractile-ring assembly in fission yeast and beyond [PDF]
Seminars in Cell and Developmental Biology, 2010 Most eukaryotes including fungi, amoebas, and animal cells assemble an actin/myosin-based contractile ring during cytokinesis. The majority of proteins implied in ring formation, maturation, and constriction are evolutionarily conserved, suggesting that common mechanisms exist among these divergent eukaryotes.
Jian-Qiu Wu
exaly +3 more sources
Cell size sets the diameter of the budding yeast contractile ring [PDF]
Nature Communications, 2020 Budding yeast cell polarization is known to self-assemble, but it is still not clear what controls the size of the resulting septin ring. Here the authors show that the septin ring diameter is set by cell volume, ensuring that larger cells have larger ...
I. V. Kukhtevich +4 more
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Mechanical power is maximized during contractile ring-like formation in a biomimetic dividing cell model [PDF]
Nature CommunicationsThe spatial and temporal dynamics of forces in cells coordinate essential behaviors like division, polarization, and migration. While intracellular signaling initiates contractile ring assembly during cell division, how mechanical forces coordinate ...
Ryota Sakamoto, Michael P. Murrell
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Mechanistic insights into the anchorage of the contractile ring by anillin and Mid1. [PDF]
Dev Cell, 2015 Anillins and Mid1 are scaffold proteins that play key roles in anchorage of the contractile ring at the cell equator during cytokinesis in animals and fungi, respectively. Here, we report crystal structures and functional analysis of human anillin and S. pombe Mid1.
Sun L +7 more
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Regulation of contractile ring formation and septation in Schizosaccharomyces pombe. [PDF]
Curr Opin Microbiol, 2015 The fission yeast Schizosaccharomyces pombe has become a powerful model organism for cytokinesis studies, propelled by pioneering genetic screens in the 1980s and 1990s. S. pombe cells are rod-shaped and divide similarly to mammalian cells, utilizing a medially-placed actin-and myosin-based contractile ring.
Willet AH, McDonald NA, Gould KL.
europepmc +4 more sources
An essential contractile ring protein controls cell division in Plasmodium falciparum [PDF]
Nature Communications, 2019 Schizogony is essential for blood stage infection of Plasmodium parasites and produces several daughter cells. Here, Rudlaff et al. identify PfCINCH and interacting proteins as essential components of the basal complex required to establish daughter cell
Rachel M. Rudlaff +3 more
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