Results 51 to 60 of about 57,995 (204)
Clinical Pharmacology &Therapeutics, EarlyView.Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples +10 more
wiley +1 more source
Abscission checkpoint control: stuck in the middle with Aurora B [PDF]
Open Biology, 2012 At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane.
Mar Carmena
doaj +1 more source
The stress and strain of cytokinesis [PDF]
Trends in Cell Biology, 2005 The ultimate goal of all signaling pathways in cytokinesis is to control the mechanical separation of the mother cell into two daughter cells. Because of the intrinsic mechanical nature of cytokinesis, it is essential to understand fully how cell shapes and the material properties of the cell are generated, how these shapes and material properties ...
Elizabeth M, Reichl +2 more
openaire +2 more sources
Embryonic development of the Mediterranean starfish Hacelia attenuata
Developmental Dynamics, EarlyView.Abstract Background Starfish play essential ecological roles as predators and ecosystem regulators; however, detailed developmental descriptions exist for only a handful of species, none of which are from the Mediterranean Sea. Results In this study, we provide the first full account of the development of the Mediterranean starfish Hacelia attenuata ...
Silvia Caballero‐Mancebo +3 more
wiley +1 more source
A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis
Plant Direct, 2023 Meiosis is a specialized cell division that halves the number of chromosomes in two consecutive rounds of chromosome segregation. In angiosperm plants is meiosis followed by mitotic divisions to form rudimentary haploid gametophytes.
Sorin Tanasa +10 more
doaj +1 more source
Centralspindlin: At the heart of cytokinesis [PDF]
Cytoskeleton, 2012 AbstractThe final step in the cell cycle is the formation of two genetically identical daughter cells by cytokinesis. At the heart of cytokinesis in animal cells is the centralspindlin complex which is composed of two proteins, a kinesin‐like protein, Mitotic kinesin‐like protein 1, and a Rho GTPase activating protein (RhoGAP), CYK‐4.
Erin A, White, Michael, Glotzer
openaire +2 more sources
Interdisciplinary Medicine, EarlyView.In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang +11 more
wiley +1 more source
Minor Kinases with Major Roles in Cytokinesis Regulation
Cells, 2022 Cytokinesis, the conclusive act of cell division, allows cytoplasmic organelles and chromosomes to be faithfully partitioned between two daughter cells.
Stefano Sechi +2 more
doaj +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos +4 more
wiley +1 more source
Developmental Cell, 2006 Temporal and spatial coordination of cytokinesis with chromosome segregation is key for successful cell division, but it is poorly understood. A recent article in Science by Pellman and coworkers (Yoshida et. al., 2006) reveals how the yeast polo-like kinase Cdc5 triggers Rho1/RhoA activation and the assembly of the contractile actin ring during ...
Rauter H, Barral Y
openaire +3 more sources