Results 31 to 40 of about 57,995 (204)
Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP
mBio, 2020 Antibiotic acyldepsipeptides (ADEPs) deregulate ClpP, the proteolytic core of the bacterial Clp protease, thereby inhibiting its native functions and concomitantly activating it for uncontrolled proteolysis of nonnative substrates.
Nadine Silber +5 more
doaj +1 more source
Frontiers in Physiology, 2022 The transformation of a single fertilised egg into an adult human consisting of tens of trillions of highly diverse cell types is a marvel of biology. The expansion is largely achieved by cell duplication through the process of mitosis.
Charlotte Nugues +2 more
doaj +1 more source
Polo-like kinase in trypanosomes: an odd member out of the Polo family [PDF]
Open Biology, 2020 Polo-like kinases (Plks) are evolutionarily conserved serine/threonine protein kinases playing crucial roles during multiple stages of mitosis and cytokinesis in yeast and animals.
Yasuhiro Kurasawa, Tai An, Ziyin Li
doaj +1 more source
Phosphoinositide Function in Cytokinesis [PDF]
Current Biology, 2011 In systems as diverse as yeast, slime mold and animal cells, the levels and distribution of phosphatidylinositol phosphates (PIPs) must be strictly regulated for successful cell cleavage. The precise mechanism by which PIPs function in this process remains unknown.
Brill, Julie A. +2 more
openaire +3 more sources
Live Imaging and Analysis of Meiotic Cytokinesis in Drosophila Testes
Bio-ProtocolAll living organisms require the division of a cell into daughter cells for their growth and maintenance. During cell division, both genetic and cytoplasmic contents are equally distributed between the two daughter cells.
Govind Kunduri, Jairaj Acharya
doaj +1 more source
Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity
eLife, 2018 Cytokinesis, the physical division of one cell into two, is powered by constriction of an actomyosin contractile ring. It has long been assumed that all animal cells divide by a similar molecular mechanism, but growing evidence suggests that cytokinetic ...
Tim Davies +6 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Architecture of the ring formed by the tubulin homologue FtsZ in bacterial cell division
eLife, 2014 Membrane constriction is a prerequisite for cell division. The most common membrane constriction system in prokaryotes is based on the tubulin homologue FtsZ, whose filaments in E. coli are anchored to the membrane by FtsA and enable the formation of the
Piotr Szwedziak +4 more
doaj +1 more source
An ATM-CHK2-INCENP pathway prevents chromatin breakage by regulating the abscission checkpoint
Molecular & Cellular Oncology, 2021 In response to chromatin bridges, the chromosomal passenger complex (CPC) delays completion of cytokinesis (abscission) to prevent chromosome breakage.
Eleni Petsalaki, George Zachos
doaj +1 more source
Frontiers in Oncology, 2021 Defects in cytoskeleton functions support tumorigenesis fostering an aberrant proliferation and promoting inappropriate migratory and invasive features.
Valentina Fragliasso +5 more
doaj +1 more source