Results 71 to 80 of about 398,785 (313)

Both Orai1 and TRPC1 are involved in excessive store-operated calcium entry in striatal neurons expressing mutant huntingtin exon 1

Frontiers in Physiology, 2015
It has been previously reported that N-terminus of mutant huntingtin (product of the 1st exon) is sufficient to cause a Huntington’s disease (HD) pathological phenotype. In view of recent data suggesting that improper regulation of store-operated calcium
Vladimir eVigont, Juliya eKolobkova, Anton eSkopin, Olga eZimina, Lyuba eGlushankova, Elena eKaznacheyeva   +5 more
doaj   +1 more source

Tear ferning test and pathological effects on ocular surface before and after topical cyclosporine in vernal keratoconjunctivitis patients [PDF]

, 2018
Background: Vernal keratoconjunctivitis (VKC) is a rare ocular surface inflammatory disease that affects mainly boys in the first decade of life.
Bianchi, Guia, Del Regno, Paola, Duse, Marzia, Lambiase, Alessandro, Nebbioso, Marcella, Sacchetti, Marta, Zicari, Anna Maria   +6 more
core   +1 more source

Artificial Intelligence‐Assisted Urine Cytology for Noninvasive Detection of Muscle‐Invasive Urothelial Carcinoma: A Multi‐Center Diagnostic Study with Prospective Validation

Advanced Science, EarlyView.
Accurate preoperative detection of muscle‐invasive urothelial carcinoma (MIUC) is crucial for clinical decision‐making. This study developed PUCAS‐M, an artificial intelligence (AI) model that analyzes urine cytology to assist in differentiating MIUC from non‐MIUC.
Runnan Shen, Fan Jiang, Xiaowei Huang, Guibin Hong, Yun Luo, Huan Wan, Ye Xie, Mengyi Zhu, Yun Wang, Bohao Liu, Ping Qin, Yahui Wang, Haoxuan Wang, Hongkun Yang, Zhen Lin, Rui Chen, Nengtai Ouyang, Jian Huang, Tianxin Lin, Shaoxu Wu   +19 more
wiley   +1 more source

Pancreatic cysts suspected to be branch duct intraductal papillary mucinous neoplasm without concerning features have low risk for development of pancreatic cancer. [PDF]

, 2015
BackgroundThe risk of developing pancreatic cancer is uncertain in patients with clinically suspected branch duct intraductal papillary mucinous neoplasm (BD-IPMN) based on the "high-risk stigmata" or "worrisome features" criteria proposed in the 2012 ...
Fehmi, Syed A, Giap, Andrew Q, Gonzalez, Ingrid, Hunt, Gordon C, Krinsky, Mary L, Kwong, Wilson T, Lawson, Robert D, Savides, Thomas J, Slezak, Jeff, Tang, Raymond S   +9 more
core   +1 more source

A Field‐Deployable RotEx‐LAMP‐LFA Platform for Molecular Triage of HPV‐Driven Oncogenesis

Advanced Science, EarlyView.
This study presents RotEx‐LAMP‐LFA, a fully integrated, battery‐powered, low‐cost point‐of‐care device for rapid cervical cancer risk detection based on HPV16/18 E6/E7 mRNA. Clinically validated, the system demonstrated high sensitivity and specificity, and showed full concordance between self‐collected and clinician‐collected samples, offering a ...
Yuan Gao, Qiang Wen, Siyuan Qiao, Linyi Deng, Keyue Li, Zhuyan Shao, Xiaonan Liu, Tao Zhu, Chao Zhang, Da Han, Weihong Tan   +10 more
wiley   +1 more source

Hippocampal glucocorticoid receptor and microRNA gene expression and serum cortisol concentration in foxes selected for behavior toward humans

Вавиловский журнал генетики и селекции, 2018
In many cases, stress reactivity is one of the important bases of aggressive behavior. It appears as if reduced stress reactivity underlies an abrupt decrease in aggression towards man in domesticated animals.
V. Yu. Ovchinnikov, E. V. Antonov, G. V. Vasilyev, S. G. Shihevich, D. V. Shepeleva, Yu. E. Herbeck   +5 more
doaj   +1 more source

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

Advanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera, Suneesh Thilak, Asha Patel, Prashant Nasa, Zubair Ahmed, Lorraine Jacques, William J. Scotton, Cyril Chacko, Randeep Mullhi, Ruoling Chen, Vikram Patil, Suresh Renukappa, Tonny Veenith   +12 more
wiley   +1 more source

History of Cervical Cancer and the Role of the Human Papillomavirus, 1960-2000 [PDF]

, 2009
Annotated and edited transcript of a Witness Seminar held on 13 May 2008. Introduction by Professor Anne M Johnson, Division of Population Health and Institute for Global Health, UCL.
Reynolds, LA, Tansey, EM
core  

A Twist in the Diagnosis: Chronic Arthropathy Without Inflammation

Arthritis Care &Research, EarlyView.
María Á. Puche‐Larrubia, Inmaculada C. Aranda‐Valera, Alejandro Escudero‐Contreras, Rosa Roldán‐Molina   +3 more
wiley   +1 more source

SP1‐Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer

Advanced Science, EarlyView.
Laser capture microdissection‐based proteomics of pancreatic intraepithelial neoplasia (PanIN) identifies specificity protein 1 (SP1) as a key driver of tumorigenesis and progression in pancreatic cancer through glycolytic remodeling. SP1 enhances aerobic glycolysis by transcriptionally activating 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase ...
Hexing Hang, Mengyu Yu, Linxi Zhu, Neng Tang, Xiao Fu, Zhenghua Cai, Minghao Yan, Yi Chen, Lei Yang, Jianzhuang Wu, Jiatong Tang, Yu Xie, Qi Li, Xu Fu, Liang Mao, Jun Chen, Fanqing Meng, Bo Kong, Xiaodong Han, Chao Yan, Yudong Qiu, Hao Cheng   +21 more
wiley   +1 more source