Results 51 to 60 of about 132,024 (267)
The role of cytomegalovirus in the development of opportunistic infections [PDF]
The Moldovan Medical Journal, 2019 Background: About one century ago, was found and described a new virus, which, due to its particular way of damaging cells, was called cytomegalovirus. Human is the only natural source of cytomegalovirus infection.
Elena Cirjau, Emilia Behta
doaj +1 more source
Dynamic Kernel Matching for Non-conforming Data: A Case Study of T-cell Receptor Datasets [PDF]
arXiv, 2021 Most statistical classifiers are designed to find patterns in data where numbers fit into rows and columns, like in a spreadsheet, but many kinds of data do not conform to this structure. To uncover patterns in non-conforming data, we describe an approach for modifying established statistical classifiers to handle non-conforming data, which we call ...
arxiv
Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics
Advanced Healthcare Materials, EarlyView.This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold +2 more
wiley +1 more source
A Noisy-Label-Learning Formulation for Immune Repertoire Classification and Disease-Associated Immune Receptor Sequence Identification [PDF]
arXiv, 2023 Immune repertoire classification, a typical multiple instance learning (MIL) problem, is a frontier research topic in computational biology that makes transformative contributions to new vaccines and immune therapies. However, the traditional instance-space MIL, directly assigning bag-level labels to instances, suffers from the massive amount of noisy ...
arxiv
Advanced Science, EarlyView.AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang +8 more
wiley +1 more source
Asymptomatic cytomegalovirus gastritis in an immunocompetent COVID-19 patient: a case report
Journal of the Pakistan Medical AssociationA number of complications are associated with COVID-19 due to reduced immunity. Of these, opportunistic infections are of great significance because of their atypical presentation and low detection rates.
Fizza Najeeb +3 more
doaj +1 more source
'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection. [PDF]
, 2010 Natural killer (NK) cells expressing inhibitory receptors that bind to self major histocompatibility complex (MHC) class I are 'licensed', or rendered functionally more responsive to stimulation, whereas 'unlicensed' NK cells lacking receptors for self ...
Lanier, Lewis L +2 more
core +3 more sources
Parasite infection in a cell population with deaths and reinfections [PDF]
arXiv, 2021 We introduce a model of parasite infection in a cell population, where cells can be infected, either at birth through maternal transmission, from a contact with the parasites reservoir, or because of the parasites released in the cell medium after the lyses of infected cells.
arxiv
Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication
Advanced Science, EarlyView.Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He +6 more
wiley +1 more source
European Journal of Inflammation, 2009 The hypothesis for a role of viral infections on the pathogenesis of systemic lupus erythematosus has been discussed in many works, particularly that of cytomegalovirus and Epstein Barr virus infections as trigger of autoimmune processes.
A. Riccio MD +5 more
doaj +1 more source