Results 71 to 80 of about 132,024 (267)

Prevention and treatment of cytomegalovirus infections in solid organ transplantation

Zdravniški Vestnik, 2011
: Human cytomegalovirus, a member of the Betaherpesviridae, has the ability to establish lifelong persistent and usually latent infection. Following primary infection (asymptomatic or symptomatic: CMV mononucleosis), cytomegalovirus disease is generally ...
Janez Tomažič
doaj  

Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. [PDF]

, 2019
Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Balogun, Rilwan, Chan, Karen, Dai, Xinghong, Jih, Jonathan, Liu, Fenyong, Liu, Wei, Mei, Ye, Trang, Phong, Yu, Xuekui, Zhou, Z Hong   +9 more
core   +2 more sources

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

An age-of-infection model with both symptomatic and asymptomatic infections [PDF]

arXiv, 2021
We formulate a general age-of-infection epidemic model with two pathways: the symptomatic infections and the asymptomatic infections. We then calculate the basic reproduction number $\mathcal{R}_0$ and establish the final size relation. It is shown that the ratio of accumulated counts of symptomatic patients and asymptomatic patients is determined by ...
arxiv  

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Adult patients with Ph+ ALL benefit from conditioning regimen of medium‐dose VP16 plus CY/TBI

Hematological Oncology, Volume 40, Issue 5, Page 1041-1055, December 2022., 2022
Abstract The medium‐dose etoposide (VP16) added on cyclophosphamide (CY)/total body irradiation (TBI) is one of the intensified myeloablative conditioning regimens used in allogenic hematopoietic stem cell transplantation (allo‐HSCT) for acute lymphoblastic leukemia (ALL).
Mari Morita‐Fujita, Yasuyuki Arai, Tadakazu Kondo, Kaito Harada, Naoyuki Uchida, Takashi Toya, Yukiyasu Ozawa, Takahiro Fukuda, Shuichi Ota, Makoto Onizuka, Yoshinobu Kanda, Yumiko Maruyama, Satoru Takada, Toshiro Kawakita, Takahide Ara, Tatsuo Ichinohe, Takafumi Kimura, Yoshiko Atsuta, Shinichi Kako   +18 more
wiley   +1 more source

Modeling viral infectious diseases and development of antiviral therapies using human induced pluripotent stem cell-derived systems [PDF]

, 2015
The recent biotechnology breakthrough of cell reprogramming and generation of induced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study the mechanisms of human diseases and to test new drugs, can be exploited to generate ...
Barzon, Luisa, Berto, Alessandro, Desole, Giovanna, Pacenti, Monia, Palu', Giorgio, Sinigaglia, Alessandro, Trevisan, Marta   +6 more
core   +5 more sources

Infecciones por citomegalovirus

Revista Cubana de Medicina General Integral, 1998
Se ofrece una revisión actualizada sobre la infección por citomegalovirus a partir de la consulta de artículos referidos de 1990 a 1996 en las bases de datos MEDLINE, LILACS, Literatura Cubana de Medicina y Noticias de Salud.
Ana Gloria Díaz Martínez, Manuela de la Caridad Valdés Abreu, Sonia Resik Aguirre   +2 more
doaj  

Belatacept associated - cytomegalovirus retinitis in a kidney transplant recipient: a case report and review of the literature

BMC Ophthalmology, 2020
Background To report the first case of belatacept-associated multidrug-resistant Cytomegalovirus retinitis in a kidney transplant recipient. Case presentation A 76-year-old African male renal allograft recipient was admitted for acute visual loss of the ...
Pierre-Guillaume Deliège, Justine Bastien, Laetitia Mokri, Charlotte Guyot-Colosio, Carl Arndt, Philippe Rieu   +5 more
doaj   +1 more source

Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection. [PDF]

, 2018
Innate immune cells quickly infiltrate the site of pathogen entry and not only stave off infection but also initiate antigen presentation and promote adaptive immunity.
A Gladiator, A Ray, AC Patera, AD Joshi, AK Furuya, AM Owyang, AV Ivanov, AY Wen, BC Xu, C Zhao, CE Andoniou, CO Simon, CR Crowe, CW Lio, D Burdette, EH Kobayashi, GJ Bancroft, GM DeNicola, H Kato, H Kawasaki, HS Zhang, HY Cho, J Bystrom, J Lee, JL Bowen, JM Lee, K Tabeta, KA Daniels, KJ Livak, KL Hokeness, KL Hokeness, KM Hsu, LR Johnson, M Boeckh, M Wagner, MA Stacey, MC Cheeran, MJ Crane, MJ Kesic, MJ Reddehase, MK Arababadi, N Nagai, NM Reddy, P Balanescu, P Ye, Q Ma, R Guabiraba, R Saddawi-Konefka, R Seelige, R Seelige, RK Thimmulappa, RL Wheat, S Jonjic, S Jordan, S Kohyama, S Mamo, S Schaedler, S Sell, SL Deshmane, SL Gaffen, SP Francis, T O’Sullivan, T Starnes, TP Salazar-Mather, V Ramirez-Carrozzi, VA Rathinam, W Hou, W Hou, X Song, X Wang, Y Iwakura, Y Shinkai, Y Yageta, Y Zhang, YL Cheng, Z Huang   +75 more
core   +3 more sources