A chimeric adenovirus‐vectored vaccine named Ad5‐Beta/Delta was developed by introducing the RBD derived from the Delta variant (containing L452R and T478K) into the full‐length spike protein of Beta variant. Immunization with Ad5‐Beta/Delta induces broad‐spectrum neutralizing activities against BA.5‐included SARS‐CoV‐2 subvariants.
Weiqi Hong+44 more
wiley +1 more source
No significant differences were found in the evolution of both groups of patients while comparing “pulse” to “low dose” groups, despite both were radically different in term of BK viral load and Banff score. Abstract Introduction As there is no specific antiviral treatment currently available for BK polyomavirus associated nephropathy (BKVAN), its ...
Julien Carrillo+8 more
wiley +1 more source
Infection with host-range mutant adenovirus 5 suppresses innate immunity and induces systemic CD4+ T cell activation in rhesus macaques. [PDF]
Ad5 is a common cause of respiratory disease and an occasional cause of gastroenteritis and conjunctivitis, and seroconversion before adolescence is common in humans.
Fritts, Linda+5 more
core +2 more sources
Plant‐derived compounds as potential leads for new drug development targeting COVID‐19
Abstract COVID‐19, which was first identified in 2019 in Wuhan, China, is a respiratory illness caused by a virus called severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Although some patients infected with COVID‐19 can remain asymptomatic, most experience a range of symptoms that can be mild to severe. Common symptoms include fever, cough,
Lingxiu Liu, Maxim Kapralov, Mark Ashton
wiley +1 more source
The potential of Ethiopian medicinal plants to treat emergent viral diseases
Abstract Ethiopians have deep‐rooted traditions of using plants to treat ailments affecting humans and domesticated animals. Approximately 80% of the population continues to rely on traditional medicine, including for the prevention and treatment of viral diseases.
Mekbib Fekadu+10 more
wiley +1 more source
Characterization Of Malaysian Isolates Of Bovine Herpes Virus I Of Buffalo Origin [PDF]
This research was carried out to investigate two isolates of bovine herpes virus I (BHV -l) isolated from buffaloes at Universiti Pertanian Malaysia , Serdang , Selangor Darul Ehsan, and compare them to a reference cattle strain of BHV- l ( Cooper ...
Cheow, Loretta Marie
core
Some observations on the outbreak of encepalo-meningornyelitis encountered in Ehime Syuso area through tweenty-eight hospitalized patients (1956) [PDF]
An outbreak of encephalomeningomyelitis in Ehime·Syuso area from April to June 1956 was clinico-virologically investigated with the materials obtained from 28 hospitalized cases and their healthy visiting relatives.
Kitamura, Isamu
core +1 more source
Treatability of U.S. Environmental Protection Agency Contaminant Candidate List Viruses: Removal of Coxsackievirus and Echovirus using Enhanced Coagulation [PDF]
Enhanced coagulation was evaluated for removal efficacy of coxsackievirus and echovirus (Contaminant Candidate List [CCL] enteroviruses), poliovirus, four potential surrogate bacteriophages, and dissolved organic carbon (DOC).
Abbaszadegan, Morteza+2 more
core +1 more source
Development of a high-throughput colorimetric Zika virus infection assay [PDF]
Zika virus (ZIKV) is an emerging pathogen that causes congenital infections which may result in birth defects, such as microcephaly. Currently, no approved treatment or vaccination is available.
Harms, Mirja+10 more
core +1 more source
Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1)-facilitated HIV restriction in astrocytes is regulated by miRNA-181a [PDF]
Background Although highly active antiretroviral therapy (HAART) has significantly reduced the morbidity and mortality in HIV patients, virus continues to reside in the central nervous system (CNS) reservoir.
Atluri, Venkata+8 more
core +1 more source