Results 81 to 90 of about 1,082,029 (359)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Heterogeneous anomalous diffusion of virus in cytoplasm of a living cell [PDF]

arXiv, 2010
The infection pathway of virus in cytoplasm of a living cell is studied from the viewpoint of diffusion theory. The cytoplasm plays a role of a medium for stochastic motion of the virus contained in the endosome as well as the free virus. It is experimentally known that the exponent of anomalous diffusion fluctuates in localized areas of the cytoplasm.
arxiv  

Activity-dependent glassy cell mechanics II: Non-thermal fluctuations under metabolic activity [PDF]

arXiv, 2023
The glassy cytoplasm, crowded with bio-macromolecules, is fluidized in living cells by mechanical energy derived from metabolism. Characterizing the living cytoplasm as a non-equilibrium system is crucial in elucidating the intricate mechanism that relates cell mechanics to metabolic activities.
arxiv  

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

A coiled‐coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor

FEBS Letters, EarlyView.
Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston, Jérôme Feuillard, Aurélie Ancelin, Joséphine Lai‐Kee‐Him, Konstantin Brodolin, Christian Chalut, Pontus Gourdon, Mickaël Blaise   +7 more
wiley   +1 more source

Vimentin downregulation is an inherent feature of murine erythropoiesis and occurs independently of lineage [PDF]

, 1990
In mammalian erythropoiesis, the mature cells of the primitive lineage remain nucleated while those of the definitive lineage are anuclear. One of the molecular and structural changes that precedes enucleation in cells of the definitive lineage is the ...
Lazarides, Elias, Sangiorgi, Frank, Woods, Catherine M.   +2 more
core  

The DNA damage response promotes Polyomavirus JC infection by nucleus to cytoplasm NF-Kappa B activation. [PDF]

, 2017
Background: Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA.
Bellizzi, Anna, Ibba, G, Palamara, ANNA TERESA, Pietropaolo, Valeria Antonietta, White, Mk, Wollebo, Hs   +5 more
core   +1 more source

Unsupervised Segmentation of Overlapping Cervical Cell Cytoplasm [PDF]

arXiv, 2015
Overlapping of cervical cells and poor contrast of cell cytoplasm are the major issues in accurate detection and segmentation of cervical cells. An unsupervised cell segmentation approach is presented here. Cell clump segmentation was carried out using the extended depth of field (EDF) image created from the images of different focal planes. A modified
arxiv  

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Sex-specific alterations in creatine metabolism in cellular compartments of peripheral blood leukocytes in type 1 diabetes

AIMS Bioengineering
The creatine (Cr)/creatine kinase (CK) system plays a crucial role in cellular energy metabolism, glucose control, and the immune response. This study aimed to investigate this system in the peripheral blood leukocytes (PBL) of Armenians with type 1 ...
Nina Alchujyan, Elena Aghajanova, Nina Movsesyan, Arthur Melkonyan, Artashes Guevorkian, Armen Andreasyan, Margarita Hovhannisyan   +6 more
doaj   +1 more source