Results 151 to 160 of about 60,691 (243)

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, EarlyView.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source

Cytochemical Characterization for Macrophages Engulf Cholesterol Crystals and Myeloperoxidase in Neutrophil Extracellular Traps (NETs) Sampled From Disrupted Aortic Plaques. [PDF]

J Histochem Cytochem
Iwa N, Noda H, Yutani C, Komatsu S, Takahashi S, Takewa M, Ohara T, Kodama K.   +7 more
europepmc   +1 more source

Cytoplasmic protein-free mRNA induces stress granules by two G3BP1/2-dependent mechanisms [PDF]

Sean J. Ihn, Laura Farlam-Williams, Alexander F. Palazzo, Hyun O. Lee   +3 more
openalex   +1 more source

Calponin‐3 is associated with epilepsy through the regulation of astrocyte activity

Brain Pathology, EarlyView.
Increased calponin‐3 expression correlates with astrocyte activation in epileptic mice, modulating adenosine metabolism regulators ADK and ENT1. Calponin‐3 overexpression increased susceptibility to epileptic seizures, while its downregulation reduces spontaneous recurrent seizures, identifying it as a potential therapeutic target for epilepsy ...
Lu Chen, Fei Yang, Wen‐Qian Yang, Ke Wang, Meng‐Shi Yang, Cheng Gou, Yan‐Ying Yu, Li‐Ling Chen, Ting‐Wan Xu, Dan Wang, Qian Wu, Qi‐Xin Zhou, Yan‐Bing Han   +12 more
wiley   +1 more source

Recognize the Significance of Detecting Toxic Granules in Sepsis. [PDF]

Juntendo Med J
Sato S.
europepmc   +1 more source

A circadian clock translational control mechanism targets specific mRNAs to cytoplasmic messenger ribonucleoprotein granules

, 2022
Kathrina Castillo, Cheng Wu, Zhaolan Ding, Osiris K. Lopez-Garcia, Emma Rowlinson, Matthew S. Sachs, Deborah Bell‐Pedersen   +6 more
openalex   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Rapid activation of p62 body-mediated autophagy in human cells under hyperosmotic stress. [PDF]

Commun Biol
Tamura N, Waguri S.
europepmc   +1 more source

Cytolytic and biochemical properties of cytoplasmic granules of murine lymphokine-activated killer cells. [PDF]

, 1986
Pierre A. Henkart, Chongkang Yue, James C. Yang, S A Rosenberg   +3 more
openalex   +1 more source

Transcription Factor TCF12‐Mediated Maternal Gene Expressions in Mouse Oocyte Are Prerequisites of Successful Fertilisation and Zygotic Genome Activation

Cell Proliferation, EarlyView.
Maternal TCF12 ensures the competence of fertilisation by controlling the expression of Astl and the proper location of cortical granules. Furthermore, maternal TCF12 maintains the phosphatase activity of PP2A by regulating the expression of Arpp19. Oocyte‐specific deletion of Tcf12 leads to fertilisation defects as well as ZGA failure at the 2‐cell ...
Lan‐Rui Cao, Chi Zhang, Zuo‐Qi Deng, Yue‐xin Qiu, Zhao Zhang, Heng‐Yu Fan, Jing Li, Hong‐Bo Wu   +7 more
wiley   +1 more source