Results 121 to 130 of about 205 (151)
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Chemical radioprotection: A critical review of amifostine as a cytoprotector in radiotherapy
Seminars in Radiation Oncology, 2003The use of chemical radioprotectors represents an obvious strategy to improve the therapeutic index in radiotherapy. Amofostine (WR-2721) has recently been approved for use in head and neck cancer to protect against radiation-induced xerostomia. Currently, the question has arisen whether amifostine could be used for radioprotection in broader terms ...
Andreassen, Christian Nicolaj +2 more
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Cytisin amidophosphate--the new cytoprotector. [PDF]
Hiroshima journal of medical sciences, 2012 This article describes the results of a clinical study of O,O dimethyl-N-cytinizylphosphate in healthy volunteers and 142 patients with the verified diagnosis of acute toxic hepatitis. The tolerability was good. The efficiency of the drug is considered to be very high, normalization of the state took less time in comparison with standard treatment; a ...
Zhumadilov, Zhaxybay +7 more
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Natural Stilbene Polyphenols as Yarrowia lipolytica Cell Cytoprotectors at Heat Stress
Biotekhnologiya, 2021Using the extremophilic yeast of Yarrowia lipolytica, a new model has been proposed to study the protective properties of stilbene polyphenols, namely resveratrol and pinosylvin, under heat shock. It was shown that a short-term thermal exposure of yeast cells (55 C, 25 min) led to a 40% decrease in the colony-forming ability of the population, a ...
N.N. Gessler +2 more
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Cancer incidences in the digestive tube: is cobalamin a small intestine cytoprotector?
Medical Hypotheses, 2000Malignancies are common in the digestive tube, although with unequal distribution among segments. The aim of this paper was to compare available interpretations of the low cancer incidence in the small bowel and high in the large bowel. Supposed mechanisms include relatively small bacterial population, large secretion of liquid and rapid transit in the
Ivandić, Ante +5 more
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The Possibility of Using Myocardial Cytoprotector Tiotriazoline in Cardiology Practice
Kardiologiia, 2016The improvement of approaches to the treatment of cardiovascular diseases is considered the number of primary concerns of modern cardiology. It is undoubtable that the main achievements of the last few decades are creation and introduction into clinical practice of metabolic drugs, which mechanism of action is assotiated with influence on basic ...
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[Cytoprotectors and their application in sports medicine].
Meditsina truda i promyshlennaia ekologiia, 2014The article presents data of literature review on potential use of cytoprotectors in sports medicine (exemplified by Mildronat medication). This group of medications improve metabolism and energy supply in tissues. One of leading indications to Mildronat use is state of low mental and physical performance, including that of athletes.
V V, Petrova +2 more
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Journal of New Medical Technologies, 2013
The article highlights the experiments on white mice and purebred cats, which simulated insulin-dependent diabetes by intra-abdominal injection of water solution streptozotocin in the dose of 15 mg/kg, which destroys (3-cells of the pancreas within 14 days and leads to increased blood glucose animals by 70-80% compared with intact animals.
E. Goncharov +17 more
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The article highlights the experiments on white mice and purebred cats, which simulated insulin-dependent diabetes by intra-abdominal injection of water solution streptozotocin in the dose of 15 mg/kg, which destroys (3-cells of the pancreas within 14 days and leads to increased blood glucose animals by 70-80% compared with intact animals.
E. Goncharov +17 more
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Purpurogallin as a cytoprotector of cultured rabbit corneal endothelium.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1995We examined the protective properties of purpurogallin, a naturally occurring phenol, in delaying necrosis of cultured corneal endothelial cells caused by oxygen free radicals. Endothelial cell cultures were prepared from New Zealand white rabbits using microcarrier cell culture techniques. Corneal endothelial cells were treated with hypoxanthine (2 mM)
D S, Rootman +4 more
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European Journal of Medicinal Chemistry, 2017
Activation of nuclear factor erythroid-2-related factor 2 (Nrf2) has been proven to be an effective means to prevent the development of cancer, and natural curcumin stands out as a potent Nrf2 activator and cancer chemopreventive agent. In this study, we synthesized a series of curcumin analogs by introducing the geminal dimethyl substituents on the ...
Zhi-Shan, Tu +4 more
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Activation of nuclear factor erythroid-2-related factor 2 (Nrf2) has been proven to be an effective means to prevent the development of cancer, and natural curcumin stands out as a potent Nrf2 activator and cancer chemopreventive agent. In this study, we synthesized a series of curcumin analogs by introducing the geminal dimethyl substituents on the ...
Zhi-Shan, Tu +4 more
openaire +2 more sources
2020
An experimental trauma was performed for the studying of morphological changes characteristics of the brain under the action of neuroprotectors soon after the brain injury. The closed craniocerebral injury was modeled by the free fall of a load on the parietooccipital area of the brain.
A.V. Deryugina +4 more
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An experimental trauma was performed for the studying of morphological changes characteristics of the brain under the action of neuroprotectors soon after the brain injury. The closed craniocerebral injury was modeled by the free fall of a load on the parietooccipital area of the brain.
A.V. Deryugina +4 more
openaire +1 more source