Results 81 to 90 of about 1,471,694 (149)

Curative‐Intent Pancreatectomy for Pancreatic Metastasis From Renal Cell Carcinoma 30 Years After Nephrectomy Following Lenvatinib Plus Pembrolizumab Therapy: A Case Report

IJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction Renal cell carcinoma (RCC) is the most common primary site of pancreatic metastases, and complete resection confers a favorable prognosis. Lenvatinib plus pembrolizumab (LEN + PEM) is standard first‐line therapy for advanced RCC; however, induction therapy before resection of pancreatic metastasis has not been reported.
Yuta Kaneko, Reo Kotorii, Kaishi Shimizu, Kazuma Miura, Yosuke Nakanishi, Ken Nakamura, Seiya Hattori, Yasuto Yagi, Toru Nishiyama, Tetsuo Momma   +9 more
wiley   +1 more source

Tumor‐Associated Mast Cells Drive Immunosuppression and Resistance to Anti‐PD‐1 Therapy in Hepatocellular Carcinoma Through CCL17/CCR4‐mediated Regulatory T‐Cell Recruitment

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Our graphical abstract summarizes a novel immunosuppressive axis in HCC whereby tumor cell‐derived SCF recruits and activates mast cells, leading to CCL17 secretion and subsequent recruitment of CCR4+ regulatory T cells. This cascade suppresses CD8+ T cell‐mediated antitumor immunity and promotes resistance to anti‐PD‐1 therapy.
Shuai Yang, Chuang Yang
wiley   +1 more source

Reply to: When surgery changes PSA: refining a cytoreductive prostatectomy trial endpoint

BJU International, EarlyView.
Xiangwei Yang, Hanqi Lei, Binyuan Yan, Jun Pang   +3 more
wiley   +1 more source

Estimating Individualized Survival Benefit of Consolidative Metastasis‐Directed Radiotherapy Following Chemoimmunotherapy in Nasopharyngeal Carcinoma With Exclusive Distant Metastasis

MedComm, Volume 7, Issue 11, November 2026.
This study integrates target trial emulation and causal machine learning to individualize consolidative metastasis‐directed radiotherapy (MDRT) for exclusively distant metastatic nasopharyngeal carcinoma. Using a multicenter cohort of 1083 patients, we confirmed overall MDRT efficacy via a cloning–censoring–weighting approach.
Xuguang Wang, Shuwei Chen, Xing Zhang, Linfei Mao, Jingtao Chen, Shida Yan, Jiawei Xie, Xianlu Gao, Liji Zheng, Yujie Zeng, Shiting Zhang, Zekun Deng, Mingyuan Du, Ming Song   +13 more
wiley   +1 more source

Evaluation of triplet therapy combined with robot‐assisted cytoreductive prostatectomy for high‐volume metastatic prostate cancer: a multicentre randomised controlled trial protocol

BJU International, Volume 138, Issue 5, Page 807-814, November 2026.
Background Prostate cancer (PCa) is the second most common cancer in men. For patients with high‐volume metastatic PCa (mPCa) who are fit for docetaxel, a triplet therapy regimen consisting of androgen deprivation therapy (ADT), chemotherapy, and an androgen receptor pathway inhibitor (ARPI) is recommended.
Xiangwei Yang, Zhuobin He, Jian Chen, Hanqi Lei, Binyuan Yan, Linze Chen, Hong Liu, Jun Pang   +7 more
wiley   +1 more source

Sustained disease control in ovarian carcinosarcoma treated with postoperative hyperthermic intraperitoneal chemotherapy and targeted maintenance: a case report

Frontiers in Medicine
ObjectiveOvarian carcinosarcoma (OCS) is a rare and highly aggressive malignancy with no established standard treatment and a poor prognosis. This case describes sustained disease control achieved through the combination of cytoreductive surgery followed
Shuo Xu, Xinjun Li, Xiangnan Zhang, Ren Xu, Lu Sang, Yanan Ren, Ning Sun, Xiao Shao, Shengpu Wang   +8 more
doaj   +1 more source

Selection of patients with DSRCT without extra-peritoneal metastases and complete cytoreductive surgery among all the patients with DSRCT.

, 2017
Selection of patients with DSRCT without extra-peritoneal metastases and complete cytoreductive surgery among all the patients with DSRCT.
A. LeCesne (3778477), J. B. Delhorme (3778444), O. Glehen (3778474), D. Orbach (3778465), S. Bonvalot (3778453), P. Terrier (3778456), D. Elias (3778480), O. Mir (3778468), S. Msika (3778462), S. Sarnacki (3778438), H. Martelli (3778447), C. Honoré (3778450), V. Atallah (3778429), P. Philippe-Chomette (3778483), V. Minard-Colin (3778471), J. Y. Blay (3778435), P. Sargos (3778432), G. Ferron (3778459), F. Bertucci (3524012), C. LePéchoux (3778441)   +19 more
core   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Subset analyses of CSM in matched cohort between cytoreductive nephrectomy versus no surgery using univariate Cox proportional hazard model.

, 2019
Subset analyses of CSM in matched cohort between cytoreductive nephrectomy versus no surgery using univariate Cox proportional hazard model.
Wenqi Wu (22612), Zhijian Zhao (389825), Guohua Zeng (288129), Yongda Liu (6260804), Xiaolu Duan (331534)   +4 more
core   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, Volume 13, Issue 55, 5 October 2026.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source