Results 111 to 120 of about 52,861 (267)

Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases.

Chemical Reviews, 2016
The AID/APOBEC family enzymes convert cytosines in single-stranded DNA to uracils, causing base substitutions and strand breaks. They are induced by cytokines produced during the body's inflammatory response to infections, and they help combat infections
Sachini U. Siriwardena, Kang Chen, A. Bhagwat   +2 more
semanticscholar   +1 more source

Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake

Advanced Science, EarlyView.
Based on the poor cartilage penetration of tFNA, a novel tFNA‐2WL with excellent cartilage permeability and perfect chondrocyte endocytosis properties is designed and fabricated. As a result, tFNA‐2WL has a nearly seven‐fold increase in the penetration depth into the cartilage, with the same excellent cell entry properties as tFNA.
Kui Huang, Qiumei Li, Huixuan Lin, Qian Shen, Yaping Wu, Taoran Tian, Chuan Ma, Sirong Shi, Jingang Xiao, Yunfeng Lin   +9 more
wiley   +1 more source

Non‐traditional encryption methods: Moving toward electrochemical cryptography

Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022
Abstract Cybersecurity and encryption are critical in diverse applications from simple emails to high‐priority government secrets. It is best accomplished by an “unbreakable” cipher or one which is only decrypted by those with a matching cipher key to the initial encryption.
Giana Biddle, Leif McGoldrick, Jan Halamek   +2 more
wiley   +1 more source

Direct Base-to-Base Transitions in ssDNA Revealed by Tip-Enhanced Raman Scattering [PDF]

arXiv, 2016
In the present contribution, specifically designed single-stranded DNA (ssDNA) sequences composed of adenine and cytosine were used as nanometric rulers to target the maximum achievable spatial resolution of tip-enhanced Raman spectroscopy (TERS) under ambient conditions.
arxiv  

Dynamics of a DNA Mismatch Site Held in Confinement Discriminate Epigenetic Modifications of Cytosine.

Journal of the American Chemical Society, 2017
The identification and discrimination of four epigenetic modifications to cytosine in the proposed active demethylation cycle is demonstrated at the single-molecule level, without the need for chemical pretreatment or labeling.
Robert P. Johnson, A. Fleming, Rukshan T. Perera, C. Burrows, H. White   +4 more
semanticscholar   +1 more source

The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression

BMC Genomic Data
CGGBP1 is a GC-rich DNA-binding protein which is important for genomic integrity, gene expression and epigenome maintenance through regulation of CTCF occupancy and cytosine methylation.
Ishani Morbia, Praveen Kumar, Aditi Lakshmi Satish, Akanksha Mudgal, Subhamoy Datta, Umashankar Singh   +5 more
doaj   +1 more source

The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC‐derived neurons to amyloid beta and phosphorylated tau‐induced neuronal dysfunction

Alzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION Human tau protein, composed of six brain‐specific isoforms, is a major driver of Alzheimer's disease (AD). The role of its isoforms however remains unclear and human AD models are scarce. METHODS We generated human MAPT– (tau–) knockout (KO) induced pluripotent stem cells (iPSC) using CRISPR/Cas9, differentiated these into ...
Sarah Buchholz, Mohamed Aghyad Al Kabbani, Michael Bell‐Simons, Lena Kluge, Cagla Cagmak, Jennifer Klimek, Natja Haag, Lukas C. Iohan, Audrey Coulon, Marcos R. Costa, Devrim Kilinc, Hans Zempel   +11 more
wiley   +1 more source

Enzymatic approaches for profiling cytosine methylation and hydroxymethylation

Molecular Metabolism, 2022
Background: In mammals, modifications to cytosine bases, particularly in cytosine-guanine (CpG) dinucleotide contexts, play a major role in shaping the epigenome.
Tong Wang, Christian E. Loo, Rahul M. Kohli   +2 more
doaj  

Corrigendum: Single Molecule Investigation of Ag+ Interactions with Single Cytosine-, Methylcytosine- and Hydroxymethylcytosine-Cytosine Mismatches in a Nanopore

Scientific Reports, 2015
Both cytosine-Ag-cytosine interactions and cytosine modifications in a DNA duplex have attracted great interest for research. Cytosine (C) modifications such as methylcytosine (mC) and hydroxymethylcytosine (hmC) are associated with tumorigenesis ...
Yong Wang, Binquan Luan, Zhiyu Yang, Xinyue Zhang, B. Ritzo, K. Gates, L. Gu   +6 more
semanticscholar   +1 more source

Global cytosine methylation in Daphnia magna depends on genotype, environment, and their interaction

Environmental Toxicology and Chemistry, 2015
The authors characterized global cytosine methylation levels in 2 different genotypes of the ecotoxicological model organism Daphnia magna after exposure to a wide array of biotic and abiotic environmental stressors.
J. Asselman, Dieter I. M. De Coninck, M. Vandegehuchte, Mieke Jansen, E. Decaestecker, L. De Meester, J. Vanden Bussche, L. Vanhaecke, Colin R. Janssen, K. D. De Schamphelaere   +9 more
semanticscholar   +1 more source