Results 141 to 150 of about 279,378 (380)

Identification of direct targets and modified bases of RNA cytosine methyltransferases

Nature Biotechnology, 2013
The extent and biological impact of RNA cytosine methylation are poorly understood, in part owing to limitations of current techniques for determining the targets of RNA methyltransferases. Here we describe 5-azacytidine–mediated RNA immunoprecipitation (
Vahid Khoddami, B. Cairns
semanticscholar   +1 more source

SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early‐Onset of Breast Cancer

Advanced Science, EarlyView.
Elevated levels of the plasticizer DEHP associate with earlier breast cancer diagnosis. DEHP enhances glutamine‐powered energy production via the transporter SLC6A14 and pushes mitochondria toward fusion, driving tumor initiation by boosting cancer stemness. Blocking SLC6A14 lowers stemness, slows tumors, and improves chemotherapy response.
Dai‐Wei Hu, Chih‐Hao Huang, Yu‐Hao He, Ya‐Ling Wei, Shu‐Wei Hu, Fang‐Ju Cheng, Thanh Kieu Huynh, Bo‐Rong Chen, Bo‐Wei Wang, Li‐Chi Kuan, Der‐Yen Lee, Ming‐Hsin Yeh, Ya‐Jen Chang, Liang‐Chih Liu, Mien‐Chie Hung, Wei‐Chien Huang   +15 more
wiley   +1 more source

Sequence‐Specific Installation of Aryl Groups in RNA via DNA‐Catalyst Conjugates

Angewandte Chemie, EarlyView.
DNA oligonucleotides carrying amine nucleophilic catalysts are employed to deliver aryl groups to complementary sites in RNA under physiological conditions. The strategy can be used to sequence‐specifically label protein‐coding RNAs, or to knock down expression selectively, with potential applications in basic transcriptome research and in future ...
Sumon Pratihar, Wenrui Zhong, Sheng Feng, Sayantan Chatterjee, Eric T. Kool   +4 more
wiley   +2 more sources

Megaloblastosis Produced by a Cytosine Antagonist [PDF]

, 1963
Robert W. Talley, V. K. Vaitkevicius
openalex   +1 more source

DNA‐Based Hydrogels for Musculoskeletal Reconstruction: Harnessing Dynamic Programmability and Multimodal Therapeutic Integration

Advanced Science, EarlyView.
DNA‐based hydrogels serve dual roles as structural scaffolds and therapeutic platforms, offering innovative solutions for musculoskeletal regeneration with multifunctional abilities. Abstract Musculoskeletal disorders, including bone fractures, osteoarthritis, and muscle injuries, represent a leading cause of global disability, revealing the urgency ...
Ruijianghan Shi, Huilu Zhan, Shan Jiang, Kaili Lin, Changyong Yuan   +4 more
wiley   +1 more source

Brief Report: Cytosine Arabinoside Therapy for Disseminated Herpes Zoster in a Patient with IgG Pyroglobulinemia [PDF]

, 1969
Eugene M. McKelvey, Hau C. Kwaan
openalex   +1 more source

Distinct Phage‐Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes

Advanced Science, EarlyView.
Distinct enzymes including dCTP deaminases (Dcds), dTMP phosphatases (Dtms), and dTTP pyrophosphatases (Dtt) are found to be responsible for dU‐DNA biosynthesis in the phages PBS1, DSS3_VP1, and PhiR1‐37. Both PhiR1‐37‐derived and synthetic dU‐DNA are resistant to cleavage by restriction enzymes and Cas12a nuclease targeting dT‐containing sites.
Yating Li, Jason Tan, Yanqin Tu, Jingnan Wu, Zaifang Zhang, Yifeng Wei, Xinan Jiao, Yan Zhou   +7 more
wiley   +1 more source

iPS cell generation-associated point mutations include many C > T substitutions via different cytosine modification mechanisms

Nature Communications
Genomic aberrations are a critical impediment for the safe medical use of iPSCs and their origin and developmental mechanisms remain unknown. Here we find through WGS analysis of human and mouse iPSC lines that genomic mutations are de novo events and ...
Ryoko Araki, Tomo Suga, Yuko Hoki, Kaori Imadome, Misato Sunayama, Satoshi Kamimura, Mayumi Fujita, Masumi Abe   +7 more
doaj   +1 more source

AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

Nature Communications, 2018
In diffuse large B-cell lymphoma (DLBCL) increased epigenetic heterogeneity in the form of cytosine methylation is known to link to a poor clinical outcome.
Matt Teater, Pilar M. Dominguez, David Redmond, Zhengming Chen, Daisuke Ennishi, David W. Scott, Luisa Cimmino, Paola Ghione, Jayanta Chaudhuri, Randy D. Gascoyne, Iannis Aifantis, Giorgio Inghirami, Olivier Elemento, Ari Melnick, Rita Shaknovich   +14 more
doaj   +1 more source

THE CRYSTAL STRUCTURE OF AN INTERMOLECULAR COMPLEX CONTAINING A GUANINE AND A CYTOSINE DERIVATIVE [PDF]

, 1963
Henry M. Sobell, Ken‐ichi Tomita, Alexander Rich   +2 more
openalex   +1 more source