Results 191 to 200 of about 279,378 (380)

Target-Organ Treatment of Neurotropic Virus Diseases: Efficacy as a Chemotherapy Tool and Comparison of Activity of Adenine Arabinoside, Cytosine Arabinoside, Idoxuridine, and Trifluorothymidine

, 1972
Lois B. Allen, Robert W. Sidwell
openalex   +1 more source

1,3‐Diazetidin‐2‐Ones: Synthetic Approaches and Therapeutic Promise within the Aza‐β‐Lactam Family

European Journal of Organic Chemistry, EarlyView.
This review explores the synthesis, reactivity, and therapeutic potential of 1,3‐diazetidin‐2‐ones—an underexplored class of aza‐β‐lactams. Emphasis is placed on synthetic challenges, emerging methodologies, and their promise as β‐lactamase‐resistant scaffolds in medicinal chemistry. 1,3‐diazetidin‐2‐ones, overlooked members of the aza‐β‐lactam family,
Jozef Kristek, Jiří Pospíšil
wiley   +1 more source

ASPICULAMYCIN, A NEW CYTOSINE NUCLEOSIDE ANTIBIOTIC IV. ANTIMYCOPLASMA ACTIVITY OF ASPICULAMYCIN IN VITRO AND IN VIVO

, 1974
Fusao Kondo, Noritoshi KITANO, Haruki Domon, MAMORU ARAI, TATSUO HANEISHI   +4 more
openalex   +2 more sources

Cytosine methylation and the ecology of intragenomic parasites.

Trends in Genetics, 1997
J. Yoder, C. Walsh, T. Bestor
semanticscholar   +1 more source

Diagnostic performance of a circulating tumor DNA‐based blood test compared to fecal immunochemical test in colorectal cancer screening

Cancer Communications, EarlyView.
Hermann Brenner, Teresa Seum, Megha Bhardwaj, Michael Hoffmeister   +3 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Effect of cytosine arabinoside on viral-specific protein synthesis in cells infected with herpes simplex virus

, 1975
Robyn L. Ward, J G Stevens
openalex   +1 more source

S-adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line [PDF]

, 1975
Thomas W. Sneider, W. Martin Teague, L.M. Rogachevsky   +2 more
openalex   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source