Results 201 to 210 of about 52,861 (267)

Enhancer‐dependent gene regulation in space, time, and malignancies

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum   +2 more
wiley   +1 more source

Treatment of acute myeloid leukemia of adults with cytosine arabinoside in combination with 6-mercaptopurine [PDF]

open access: bronze, 1973
John G. Buchanan   +4 more
openalex   +1 more source

DNA methylation signatures of cervical pre‐invasive and invasive disease: An epigenome‐wide association study

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Cervical cancer screening programmes could benefit from an accurate triage test for human papillomavirus‐positive women based on self‐sampling. This epigenome‐wide association study examined a large number of cervical cancers and cervical intraepithelial neoplasias grade 3 (CIN3) compared to controls using the 850 k EPIC methylation array ...
Sarah J. Bowden   +9 more
wiley   +1 more source

Radical Transformation in Irradiated Cytosine and Derivatives as Studied by E.P.R. [PDF]

open access: bronze, 1972
Gunter Hartig   +2 more
openalex   +1 more source

Leveraging core enzyme structures for microbiota targeted functional regulation: Urease as an example

open access: yesiMeta, EarlyView.
We present an innovative methodology that integrates core enzyme identification, protein structural characterization, regulator virtual screening, and functional validation to achieve precise microbiome functional regulation. As a proof of concept, we focused on the regulation of urea decomposition by the rumen microbiota in ruminants. This methodology
Shengguo Zhao   +9 more
wiley   +1 more source

Nanomaterials for acute myeloid leukemia therapy: Current progress and future perspectives

open access: yesInterdisciplinary Medicine, EarlyView.
Infographics of this review introducing the current treatment strategies, types of nanomaterials, and their advantages in AML treatment (Created with BioRender.com, a license purchased, accessed on March 26, 2024). Abstract Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy characterized by poor prognosis, high relapse rates ...
Jiarui Zhao   +8 more
wiley   +1 more source

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