Results 231 to 240 of about 52,861 (267)
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
Small, EarlyView.The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa +4 more
wiley +1 more source
Nano‐Phase Separation and Analyte Binding in Aptasensors Investigated by Nano‐IR Spectroscopy
Small, EarlyView.An atomic force microscopy ‐ infrared spectroscopy (AFM‐IR) study on the fabrication of an aptamer‐based biosensor revealed the formation of nanodomains rich in DNA aptamers and blocking polyethylene glycol (PEG) molecules. Single‐molecule spectroscopy of the analyte protein is also reported.
Nafiseh Samiseresht +5 more
wiley +1 more source
Understanding of endo/lysosomal escape of nanomaterials in biomedical application
Smart Molecules, EarlyView.This review summarized mainstream mechanisms of endo/lysosomal escape and design strategies of endo/lysosomal escapable nanoparticles in view of surface charge, polarity & hydrophobicity, particle morphology, and lysosomal escape agents. The utilization of endo/lysosomal escapable nanoparticles for vaccine delivery and genetic engineering are ...
Xin Wang +3 more
wiley +1 more source
Small Science, EarlyView.Two‐dimensional graphene‐based nanomaterials are of significant interest in biomedical applications due to their unique physicochemical properties. Computational modeling provides useful insights into their structure and interactions with biological systems, aiding the nanoparticle design.
Alexa Kamboukos +2 more
wiley +1 more source
Recent Advances in Biosensors Based on Hybridization Chain Reaction and Silver Nanoclusters
Small Methods, EarlyView.This review explores the integration of hybridization chain reaction (HCR) with silver nanoclusters (AgNCs) to form hybrid HCR‐AgNCs biosensors, highlighting advancements in their design, performance, and practical applications. It covers recent innovations, methodological improvements, and the potential of HCR‐AgNCs systems as detectors across various
Zheng Wei Wong, Siu Yee New
wiley +1 more source
Shining Bright at 960 nm: A 28‐Silver‐Atom Nanorod Stabilized by DNA
Small Structures, EarlyView.Single‐crystal X‐ray data reveal the structure of a 28‐silver‐atom cluster wrapped within two DNA oligomers. In the crystalline state, two chlorido ligands are detected, which are absent in the mass spectrometry data of the solution state. With 12 valence electrons, the silver cluster has an absorption band situated at 835 nm and an emission peaking at
Giacomo Romolini +8 more
wiley +1 more source
United European Gastroenterology Journal, EarlyView.ABSTRACT The heterogeneity and suboptimal efficacy of biological treatments and small molecule drugs necessitate their precise selection based on biomarkers that predict therapeutic responses in inflammatory bowel disease. Recent studies have identified numerous novel biomarkers predictive of responses to biologics and small molecule modulators ...
Liru Chen +14 more
wiley +1 more source