Results 21 to 30 of about 120,463 (173)
Shape resonance induced electron attachment to Cytosine: The effect of aqueous media [PDF]
arXiv, 2023 We have investigated the impact of microsolvation on the shape resonance states of nucleobases, taking cytosine as a case study. To characterize the resonance position and decay width of the metastable states, we employed the newly developed DLPNO-based EA-EOMCCSD method in conjunction with resonance via Pad\'e approximation. Our calculations show that
arxiv
The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites
Nature Structural Biology, 2001 Cryptolepine, a naturally occurring indoloquinoline alkaloid used as an antimalarial drug in Central and Western Africa, has been found to bind to DNA in a formerly unknown intercalation mode. Evidence from competition dialysis assays demonstrates that cryptolepine is able to bind CG-rich sequences containing nonalternating CC sites.
Lisgarten, J.N. +4 more
openaire +5 more sources
An Unusual 500,000 Bases Long Oscillation of Guanine and Cytosine Content in Human Chromosome 21 [PDF]
Computational Biology and Chemistry, 28(5-6): 393-399 (2004), 2004 An oscillation with a period of around 500 kb in guanine and cytosine content (GC%) is observed in the DNA sequence of human chromosome 21. This oscillation is localized in the rightmost one-eighth region of the chromosome, from 43.5 Mb to 46.5 Mb. Five cycles of oscillation are observed in this region with six GC-rich peaks and five GC-poor valleys ...
arxiv +1 more source
Universal 1/f noise, cross-overs of scaling exponents, and chromosome specific patterns of GC content in DNA sequences of the human genome [PDF]
Physical Review E, 71, 041910 (2005), 2004 Spatial fluctuations of guanine and cytosine base content (GC%) are studied by spectral analysis for the complete set of human genomic DNA sequences. We find that (i) the 1/f^alpha decay is universally observed in the power spectra of all twenty-four chromosomes, and that (ii) the exponent alpha \approx 1 extends to about 10^7 bases, one order of ...
arxiv +1 more source
Spectral Analysis of Guanine and Cytosine Fluctuations of Mouse Genomic DNA [PDF]
Fluctuation and Noise Letters, 4(3):L453-L464 (2004), 2004 We study global fluctuations of the guanine and cytosine base content (GC%) in mouse genomic DNA using spectral analyses. Power spectra S(f) of GC% fluctuations in all nineteen autosomal and two sex chromosomes are observed to have the universal functional form S(f) \sim 1/f^alpha (alpha \approx 1) over several orders of magnitude in the frequency ...
arxiv +1 more source
Cytosine Arabinoside-Induced Vasculitis [PDF]
Mayo Clinic Proceedings, 1998 Dermatologic side effects of cytosine arabinoside (ara-C) are rare and most commonly occur after high-dose (more than 100 to 200 mg/m2 per day) therapy has been administered for several days. Although vascular reactions after combination chemotherapeutic regimens with ara-C have been anecdotally described, they have not been previously reported after ...
Ko-Ron Chen +3 more
openaire +2 more sources
Cytosine modifications in neurodevelopment and diseases [PDF]
Cellular and Molecular Life Sciences, 2013 DNA methylation has been studied comprehensively and linked to both normal neurodevelopment and neurological diseases. The recent identification of several new DNA modifications, including 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine, has given us a new perspective on the previously observed plasticity in 5mC-dependent regulatory ...
Bing Yao, Peng Jin
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REMPI spectroscopy of cytosine [PDF]
Chemical Physics Letters, 2002 We report resonant two-photon ionization spectra of laser desorbed, jet cooled, cytosine, 1-methyl cytosine, 5-methyl cytosine, and dimers of these. Unlike other pyrimidine bases, cytosine exhibits vibronic spectra with sharp features in two spectral regions, separated by about 5000 cm 1 .
M. Müller +3 more
openaire +2 more sources
Hidden complexities in the unfolding mechanism of a cytosine-rich DNA strand [PDF]
arXiv, 2011 We investigate the unfolding pathway of a cytosine-rich DNA hairpin structure via Molecular Dynamics simulations. Our results indicate a hidden complexity present in the unfolding process. W e show that this complex behavior arises due to non-stochastic contributions which have an important impact on the description of the dynamics in terms of ...
arxiv
Transcriptional Similarity in Couples Reveals the Impact of Shared Environment and Lifestyle on Gene Regulation through Modified Cytosines [PDF]
, 2016 Gene expression is a complex and quantitative trait that is influenced by both genetic and non-genetic regulators including environmental factors. Evaluating the contribution of environment to gene expression regulation and identifying which genes are more likely to be influenced by environmental factors are important for understanding human complex ...
arxiv +1 more source