Results 21 to 30 of about 279,378 (380)

Protonated nucleobases are not fully ionized in their chloride salt crystals and form metastable base pairs further stabilized by the surrounding anions

IUCrJ, 2018
This paper presents experimental charge-density studies of cytosinium chloride, adeninium chloride hemihydrate and guaninium dichloride crystals based on ultra-high-resolution X-ray diffraction data and extensive theoretical calculations.
Prashant Kumar, Malgorzata Katarzyna Cabaj, Aleksandra Pazio, Paulina Maria Dominiak   +3 more
doaj   +1 more source

Tricky Topology: Persistence of Folded Human Telomeric i-Motif DNA at Ambient Temperature and Neutral pH

Frontiers in Chemistry, 2020
i-Motifs are four-stranded DNA structures formed from sequences rich in cytosine, held together by hemi-protonated cytosine-cytosine base pairs. These structures have been utilized extensively as pH-switches in DNA-based nanotechnology.
Mahmoud A. S. Abdelhamid, Mahmoud A. S. Abdelhamid, Zoë A. E. Waller, Zoë A. E. Waller   +3 more
doaj   +1 more source

Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice

Science, 2019
Spotting off-targets from gene editing Unintended genomic modifications limit the potential therapeutic use of gene-editing tools. Available methods to find off-targets generally do not work in vivo or detect single-nucleotide changes.
Shuai Jin, Y. Zong, Q. Gao, Zixu Zhu, Yanpeng Wang, P. Qin, Chengzhi Liang, Daowen Wang, J. Qiu, Feng Zhang, Caixia Gao   +10 more
semanticscholar   +1 more source

Radiological Evaluation of Huntington’s Disease: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Huntington’s Disease (HD) is a rare neurodegenerative condition inherited in an autosomal dominant pattern, where Gamma Amino Butyric Acid-ergic (GABAergic) neurons in the basal ganglia progressively deteriorate.
Soumyabrata Debnath, R Harshith
doaj   +1 more source

5-Fluorocytosine/Isocytosine Monohydrate. The First Example of Isomorphic and Isostructural Co-Crystal of Pyrimidine Nucleobases

Crystals, 2020
To date, despite the crucial role played by cytosine, uracil, and thymine in the DNA/RNA replication process, no examples showing isomorphic and isostructural behavior among binary co-crystals of natural or modified pyrimidine nucleobases have been so ...
Gustavo Portalone
doaj   +1 more source

Methylated DNA recognition during the reversal of epigenetic silencing is regulated by cysteine and cerine residues in the Epstein-Barr Virus lytic switch protein [PDF]

, 2008
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with various malignancies, including Burkitt's lymphoma and nasopharyngeal carcinoma.
A Prokhortchouk, AJ Sinclair, Alison J. Sinclair, Bill Sugden, C Petosa, C Schelcher, C Schelcher, Carlo Petosa, Celine Schelcher, E Flemington, EA Merritt, Elizabeth Verrall, F Watt, G Miller, KF Macsween, LS Young, M Gromiha, MR Hicks, MR Hicks, N Nagano, P Wang, PM Bhende, PM Bhende, Questa H. Karlsson, R Feederle, RJ Klose, RM Esnouf, SJ Bark-Jones, T Tsurumi, TA Jones, U Heinemann, YF Chiu   +31 more
core   +3 more sources

Detecting DNA cytosine methylation using nanopore sequencing

Nature Methods, 2017
In nanopore sequencing devices, electrolytic current signals are sensitive to base modifications, such as 5-methylcytosine (5-mC). Here we quantified the strength of this effect for the Oxford Nanopore Technologies MinION sequencer.
J. Simpson, J. Simpson, R. Workman, P. Zuzarte, Matei David, L. Dursi, W. Timp   +6 more
semanticscholar   +1 more source

Synthesis and Structural Study of Some Pyrimidinium Hexafluoridosilicates

Acta Chimica Slovenica, 2015
The synthesis and spectroscopic characterization of some pyrimidinium hexafluoridosilicate salts with the formula (RH)2[SiF]6 (where R = 2-aminopyrimidine (1), cytosine (2) and 5-cyanocytosine (3)) is obtained in the reaction of SiO2 with hydrofluoric ...
Andrej Pevec
doaj   +1 more source

Assessing the preservation of cytosine methylation in ancient DNA from five prehistoric Native American populations [PDF]

, 2015
textCytosine methylation of CpG dinucleotides is an important epigenetic mark that regulates gene expression in humans. While methylation patterns in extant populations have been widely studied, few studies have attempted to analyze methylation in ...
Smith, Ricky Wayne Aldon
core   +1 more source

Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses

Nature Biomedical Engineering, 2019
The success of base editors for the study and treatment of genetic diseases depends on the ability to deliver them in vivo to the relevant cell types. Delivery via adeno-associated viruses (AAVs) is limited by AAV packaging capacity, which precludes the ...
Jonathan M. Levy, Wei-Hsi Yeh, Nachiket Pendse, Jessie R. Davis, E. Hennessey, Rossano Butcher, Luke W. Koblan, J. Comander, Qin Liu, David R. Liu   +9 more
semanticscholar   +1 more source