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Metabolic Signatures of Aging and Gametogenesis in Hydra oligactis
Hydra oligactis undergoes cold‐induced sexual differentiation and aging, culminating in death. GC–MS‐based metabolite profiling revealed signatures of gametogenesis, for example, polyamine accumulation, and of aging, such as loss of cytoprotection and neurotransmitter function, including taurine depletion.
Nicki Marami‐Zonouz +6 more
wiley +1 more source
Mutant IDH1/2 produces D‐2‐hydroxyglutarate, establishing the G‐CIMP methylation phenotype while permitting epigenetic evolution during glioma progression. DNA methylation profiling supports tumour classification, lower‐ versus high‐grade subclassification and broad copy‐number assessment, but A_IDH_HG/G‐CIMP‐low signatures must be integrated with ...
Pietro Tralongo +10 more
wiley +1 more source
Diversity of cytosine methylation across the fungal tree of life. [PDF]
Bewick AJ +7 more
europepmc +1 more source
ABSTRACT Microorganism and plant interactions are crucial for development and environmental adaptation. Plant growth promoting bacteria enhance agricultural productivity in a sustainable manner, while epigenetic modifications such as DNA methylation regulate gene expression and adaptive responses.
Pedro Igor Zocateli +12 more
wiley +1 more source
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Abstract Epigenetic markers, particularly DNA methylation, are promising tools for monitoring athlete health and training due to their role in cellular regulation, exercise responsiveness and molecular stability. However, exercise‐induced epigenetic changes in peripheral blood in trained individuals remain unexplored.
C. D. Goldsmith +6 more
wiley +1 more source
Reassessment of Viroid RNA Cytosine Methylation Status at the Single Nucleotide Level. [PDF]
Di Serio F +3 more
europepmc +1 more source
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DNA cytosine methylation in plant development
Journal of Genetics and Genomics, 2010Cytosine bases of the nuclear genome in higher plants are often extensively methylated. Cytosine methylation has been implicated in the silencing of both transposable elements (TEs) and endogenous genes, and loss of methylation may have severe functional consequences.
Bao Liu, Meishan Zhang
exaly +3 more sources
Cytosine methylation and human cancer
Current Opinion in Oncology, 2000Abnormalities of genomic methylation patterns have been attributed a role in carcinogenesis since the early 1980s, when large-scale demethylation of the genome was thought be an early event in multistep colorectal carcinogenesis. In the 1990s, local de novo methylation (with or without global demethylation) at tumor suppressor loci was held to be ...
P M, Warnecke, T H, Bestor
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