Results 181 to 190 of about 57,661 (242)

TET2 as a Context‐Dependent Epigenetic Integrator in Clonal Hematopoiesis, Inflammation, Cancer, and Immunotherapy

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Ten‐Eleven Translocation 2 (TET2) is an Fe(II)‐ and α‐ketoglutarate‐dependent dioxygenase that initiates active DNA demethylation by oxidizing 5‐methylcytosine (5mC). Beyond this enzymatic role, TET2 links DNA methylation dynamics with chromatin regulation, cellular metabolism, immune‐cell identity, and treatment response in a context ...
XiaoJie Liu, Jiangchen Liu, Liu Feng, Dan Xu, Xianling Wei, Dekuai Tong   +5 more
wiley   +1 more source

Correlation of the peripheral blood DNA methylation profile and immune‐related adverse events in patients with solid cancer treated with immune checkpoint inhibitors

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Baseline blood DNA methylation profiles predict early immune‐related adverse events across cancer types. A methylation‐based classifier demonstrated robust discriminatory performance and revealed enrichment of neuronal and developmental regulatory pathways, suggesting a systemic epigenetic predisposition to immune toxicity following immune checkpoint ...
Markus Kleinberger, Angelika Martina Starzer, Erwin Tomasich, Julia Maria Berger, Vincent Sunder‐Plassmann, Lynn Gottmann, Isabella Solano Henao, Martin Korpan, Josef Fuerst, Nikola Vladic, Cihan Ay, Helmuth Haslacher, Julia Furtner, Matthias Preusser, Gerwin Heller, Anna Sophie Berghoff   +15 more
wiley   +1 more source

Effects of Temperature Treatments on Cytosine-Methylation Profiles of Diploid and Autotetraploid Plants of the Alpine Species Ranunculus kuepferi (Ranunculaceae). [PDF]

Front Plant Sci, 2020
Syngelaki E, Schinkel CCF, Klatt S, Hörandl E.   +3 more
europepmc   +1 more source

Correction: Dissecting cytosine methylation mechanics of dysmetabolism. [PDF]

Aging (Albany NY), 2019
Cencioni C, Gaetano C, Spallotta F.
europepmc   +1 more source

Epigenetic and Brain Structure Covariation Patterns in Typical and Atypical Development

Human Brain Mapping, Volume 47, Issue 11, 01 August 2026.
We present a map linking DNA methylation to brain structure in childhood. Genes in which methylation was linked to brain anatomy are highly enriched for those implicated in psychiatric and neurodevelopmental disorders, highlighting potential epigenetic targets for understanding both typical and atypical brain development.
Valentine Chirokoff, Jo Wrigglesworth, Peter Daniel Fransquet, Yen Ting Wong, Jeffrey M. Craig, Tim J. Silk   +5 more
wiley   +1 more source

Challenges in Quantifying Cytosine Methylation in the HIV Provirus. [PDF]

mBio, 2019
LaMere SA, Chaillon A, Huynh C, Smith DM, Gianella S.   +4 more
europepmc   +1 more source

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source

Levels of DNA cytosine methylation in the Drosophila genome. [PDF]

PeerJ, 2018
Deshmukh S, Ponnaluri VC, Dai N, Pradhan S, Deobagkar D.   +4 more
europepmc   +1 more source

Cytosine DNA Methylation Is Found in

Analytical Chemistry, 2014
Floriana Capuano, Michael Mülleder, Robert Kok, Henk J Blom, Markus Ralser   +4 more
openaire   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source