Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System
Advanced Functional Materials, EarlyView.A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim +4 more
wiley +1 more source
mTOR pathway inhibition alters proliferation as well as differentiation of neural stem cells
Frontiers in Cellular NeuroscienceIntroductionNeural stem cells (NSCs) are essential for both embryonic development and adult neurogenesis, and their dysregulation causes a number of neurodevelopmental disorders, such as epilepsy and autism spectrum disorders.
Nataliya Romanyuk +8 more
doaj +1 more source
Chemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrest
Frontiers in Immunology, 2012 Leukocyte trafficking to acute sites of injury or infection requires spatial and temporal cues that fine tune precise sites of firm adhesion and guide migration to endothelial junctions where they undergo diapedesis to sites of insult.
Neha eDixit, Scott I Simon
doaj +1 more source
Advanced Functional Materials, EarlyView.Non‐covalent protein–protein interactions mediated by SH3, PDZ, or GBD domains enable the self‐assembly of stable and biocatalytically active hydrogel materials. These soft materials can be processed into monodisperse foams that, once dried, exhibit enhanced mechanical stability and activity and are easily integrated into microstructured flow ...
Julian S. Hertel +5 more
wiley +1 more source
Neurofilaments and tau proteins in cerebrospinal fluid and serum in dementias and neuroinflammation
Biomedical Papers, 2017 Aims: The aim of this study was to evaluate the diagnostic potential of cerebrospinal fluid (CSF) and serum levels of neurocytoskeletal proteins and their ratios for the diagnosis of dementias and to assess the differences in neurocytoskeletal proteins ...
Lenka Fialova +2 more
doaj +1 more source
Diversity and Potential Multifunctionality of Archaeal CetZ Tubulin-like Cytoskeletal Proteins. [PDF]
Biomolecules, 2023 Brown HJ, Duggin IG.
europepmc +1 more source
The cytoplasmic domain of L-selectin interacts with cytoskeletal proteins via alpha-actinin: receptor positioning in microvilli does not require interaction with alpha-actinin. [PDF]
, 1995 Fredrick M. Pavalko +5 more
openalex +1 more source
Advanced Functional Materials, EarlyView.A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker +16 more
wiley +1 more source
Japan-US symposium on cytoskeletal motor proteins and their associated proteins
Biophysics and Physicobiology, 2021 Kumiko Hayashi, Shinsuke Niwa
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Characterisation of the in vitro activity of a Nitazoxanide-N-methyl-1H-benzimidazole hybrid molecule against albendazole and nitazoxanide susceptible and resistant strains of Giardia intestinalis and its in vivo giardicidal activity [PDF]
Memorias do Instituto Oswaldo CruzBACKGROUND It was previously demonstrated that CMC-20, a nitazoxanide and N-methyl-1H-benzimidazole hybrid molecule, had higher in vitro activity against Giardia intestinalis WB strain than metronidazole and albendazole and similar to nitazoxanide ...
Félix Matadamas-Martínez +7 more
doaj +2 more sources