Results 91 to 100 of about 555,685 (380)

Force balance and membrane shedding at the Red Blood Cell surface

, 2006
During the aging of the red-blood cell, or under conditions of extreme echinocytosis, membrane is shed from the cell plasma membrane in the form of nano-vesicles.
D. E. Discher, J. M. Werre, L. Backman, N. G. Van Kampen, Nir Gov, Pierre Sens, R. Bucki, R. E. Waugh, S. Levin, S.-C. Liu, S. P. Sutera, V. Bennett, W. H. Reinhart, Z. Tochner   +13 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Motor-driven advection competes with crowding to drive spatiotemporally heterogeneous transport in cytoskeleton composites

Frontiers in Physics, 2022
The cytoskeleton–a composite network of biopolymers, molecular motors, and associated binding proteins–is a paradigmatic example of active matter. Particle transport through the cytoskeleton can range from anomalous and heterogeneous subdiffusion to ...
Janet Y. Sheung, Janet Y. Sheung, Jonathan Garamella, Stella K. Kahl, Brian Y. Lee, Ryan J. McGorty, Rae M. Robertson-Anderson   +6 more
doaj   +1 more source

HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells [PDF]

, 2015
The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in
Angela, Catizone, Caruso, Maria, Galdieri, Michela, Ricci, Giulia, Rita, Canipari, Scheri, Katia Corano, Virginia, Di Paolo   +6 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Deregulated expression of cytoskeleton related genes in the spinal cord and sciatic nerve of presymptomatic SOD1G93A Amyotrophic Lateral Sclerosis mouse model

Frontiers in Cellular Neuroscience, 2014
Early molecular events related to cytoskeleton are poorly described in Amyotrophic Lateral Sclerosis (ALS), especially in the Schwann cell (SC), which offers strong trophic support to motor neurons.
Jessica Ruivo Maximino, Gabriela Pintar de Oliveira, Chrystian Junqueira Alves, Gerson eChadi   +3 more
doaj   +1 more source

Compartmentalisation and localisation of the translation initiation factor (eIF) 4F complex in normally growing fibroblasts [PDF]

, 2006
Previous observations of association of mRNAs and ribosomes with subcellular structures highlight the importance of localised translation. However, little is known regarding associations between eukaryotic translation initiation factors and cellular ...
Barbarese, Bassell, Bergamini, Biegel, Bonneau, Bushell, Bushell, Caron, Carson, Cervera, Chicurel, Clore, Coldwell, Cowan, Cuesta, Culjkovic, Dang, Delom, Farina, Farmer, Hamill, Hasek, Hill, Hou, Hovland, Hudder, Jansen, Jansen, Jockusch, Kedersha, Kedersha, Kedersha, Kedersha, Kim, Kimball, Kislauskis, Kloc, Latham, Lemieux, Lenk, Lerner, Lerner, Levadoux, Lin, Lindemann, Liu, Mark Willett, Mickleburgh, Micklem, Moore, Moore, Munshi, Murray, Negrutskii, Negrutskii, Negrutskii, Nicchitta, Ornelles, Palacek, Patrick, Pincheira, Prahlad, Pramanik, Prevot, Ramaekers, Shestakova, Simon A. Flint, Simon J. Morley, Smart, Stapulionis, Stapulionis, Svitkin, Svitkin, Taneja, Thoma, Traub, Trombetta, Umikawa, Valouev, van Venrooij, Virginia M. Pain, Wang, Woods   +82 more
core   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis

Molecular Cancer, 2018
Some of the key steps in cancer metastasis are the migration and invasion of tumor cells; these processes require rearrangement of the cytoskeleton.
Yanyan Tang, Yi He, Ping Zhang, Jinpeng Wang, Chunmei Fan, Liting Yang, F. Xiong, Shanshan Zhang, Zhaojian Gong, Shaolin Nie, Q. Liao, Xiayu Li, Xiaoling Li, Yong Li, Gui-yuan Li, Zhaoyang Zeng, W. Xiong, Can Guo   +17 more
semanticscholar   +1 more source

Receptor-Mediated Endocytosis of a Cylindrical Nanoparticle in the Presence of Cytoskeleton Substrate

, 2019
Internalization of particles by cells plays a crucial role for adsorbing nutrients and fighting infection. Endocytosis is one of the most important mechanisms of the particles uptake which encompass multiple pathways.
Khosravanizadeh, Amir, Mohammad-Rafiee, Farshid, Sens, Pierre   +2 more
core   +1 more source