Results 1 to 10 of about 336,446 (348)
Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway
Nature, 2020 In mammalian cells, mitochondrial dysfunction triggers the integrated stress response, in which the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) results in the induction of the transcription factor ATF4 1 – 3 .
Giovanni Aviles +2 more
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Journal of Lipid Research, 1980 This study reports the isolation and partial characterization of a soluble protein with binding specificity for retinoic acid from rat testis cytosol.
A C Ross, N Adachi, D S Goodman
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Efficient Delivery of Quantum Dots into the Cytosol of Cells Using Cell-Penetrating Poly(disulfide)s
Journal of the American Chemical Society, 2017 Quantum dots (QDs) are extremely bright, photostable, nanometer particles broadly used to investigate single molecule dynamics in vitro. However, the use of QDs in vivo to investigate single molecule dynamics is impaired by the absence of an efficient ...
Emmanuel Derivery +2 more
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Mycobacterium tuberculosis subverts the TLR-2-MyD88 pathway to facilitate its translocation into the cytosol. [PDF]
PLoS ONE, 2014 Mycobacterium tuberculosis (M.tb) has evolved mechanisms to evade its destruction in phagolysosomes, where it successfully survives and replicates within phagocytes.
Aejazur Rahman +4 more
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Zinc transporters belonging to the Cation Diffusion Facilitator (CDF) family have complementary roles in transporting zinc out of the cytosol. [PDF]
PLoS Genetics, 2018 Zinc is an essential trace element that is required for the function of a large number of proteins. As these zinc-binding proteins are found within the cytosol and organelles, all eukaryotes require mechanisms to ensure that zinc is delivered to ...
Sangyong Choi +4 more
doaj +3 more sources
Special delivery: distributing iron in the cytosol of mammalian cells [PDF]
Frontiers in Pharmacology, 2014 Eukaryotic cells contain hundreds of proteins that require iron cofactors for activity. These iron enzymes are located in essentially every subcellular compartment; thus, iron cofactors must travel to every compartment in the cell.
Caroline C. Philpott, Moon‐Suhn Ryu
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eLife, 2018 Drugs called bisphosphonates are used to treat a range of bone diseases, but how do they reach the enzymes that are their target?
Michael J Rogers, Marcia A Munoz
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A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol
Nature, 2020 Evelyn Fessler +2 more
exaly +2 more sources
Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells
Molecules and Cells, 2014 Caroline A. Lewis +9 more
openalex +3 more sources