Results 1 to 10 of about 256,621 (293)

Tumor-specific cytosol-penetrating antibodies for antigen- and TME-dependent intracellular cargo delivery [PDF]

Molecular Therapy: Oncology
Although a considerable number of disease-related biomolecular interactions occur in the cytosol, therapeutic and diagnostic application of target-specific binding proteins is largely confined to surface-exposed or extracellular targets.
Carolin Sophie Dombrowsky, Felix Klaus Geyer, Diana Zakharchuk, Harald Kolmar   +3 more
doaj   +2 more sources

Comparison of translational and rotational modes towards passive rheology of the cytoplasm of MCF-7 cells using optical tweezers

Frontiers in Physics, 2023
A colloidal particle placed inside the cell cytoplasm is enmeshed within a network of cytoskeletal fibres immersed in the cytosolic fluid. The translational mode is believed to yield different rheological parameters than the rotational mode, given that ...
Srestha Roy, Rahul Vaippully, Muruga Lokesh, Gokul Nalupurackal, Privita Edwina, Saumendra Bajpai, Basudev Roy   +6 more
doaj   +1 more source

Co-cultured methanogen improved the metabolism in the hydrogenosome of anaerobic fungus as revealed by gas chromatography-mass spectrometry analysis [PDF]

Asian-Australasian Journal of Animal Sciences, 2020
Objective The purpose of this study was to reveal the metabolic shift in the fungus co-cultured with the methanogen (Methanobrevibacter thaueri). Methods Gas chromatography-mass spectrometry was used to investigate the metabolites in anaerobic fungal ...
Yuqi Li, Meizhou Sun, Yuanfei Li, Yanfen Cheng, Weiyun Zhu   +4 more
doaj   +1 more source

Proteomic Shifts Reflecting Oxidative Stress and Reduced Capacity for Protein Synthesis, and Alterations to Mitochondrial Membranes in Neurospora crassa Lacking VDAC

Microorganisms, 2022
Voltage-dependent anion-selective channels (VDAC) maintain the bidirectional flow of small metabolites across the mitochondrial outer membrane and participate in the regulation of multiple cellular processes.
Sabbir R. Shuvo, Anna Motnenko, Oleg V. Krokhin, Victor Spicer, Deborah A. Court   +4 more
doaj   +1 more source

Sub-Cellular Metabolomics Contributes Mitochondria-Specific Metabolic Insights to a Mouse Model of Leigh Syndrome

Metabolites, 2021
Direct injury of mitochondrial respiratory chain (RC) complex I by Ndufs4 subunit mutations results in complex I deficiency (CID) and a progressive encephalomyopathy, known as Leigh syndrome.
Gunter van der Walt, Jeremie Z. Lindeque, Shayne Mason, Roan Louw   +3 more
doaj   +1 more source

Ser-Thr phosphatases in the rat brain that dephosphorylate phospho-Ser(1291)-GluN2A subunit of glutamate receptor [PDF]

The Ukrainian Biochemical Journal, 2023
N-methyl-D-aspartate receptors (NMDARs), are one of the major ionotropic glutamate receptors found in excitatory synapses which play a key role in glutamatergic synaptic transmission.
R. R. Prabhu
doaj   +1 more source

Size of the protein-protein energy funnel in crowded environment

Frontiers in Molecular Biosciences, 2022
Association of proteins to a significant extent is determined by their geometric complementarity. Large-scale recognition factors, which directly relate to the funnel-like intermolecular energy landscape, provide important insights into the basic rules ...
Nathan W. Jenkins, Petras J. Kundrotas, Ilya A. Vakser, Ilya A. Vakser   +3 more
doaj   +1 more source

Simple and Efficient Protocol for Subcellular Fractionation of Normal and Apoptotic Cells

Cells, 2021
Subcellular fractionation approaches remain an indispensable tool among a large number of biochemical methods to facilitate the study of specific intracellular events and characterization of protein functions.
Viacheslav V. Senichkin, Evgeniia A. Prokhorova, Boris Zhivotovsky, Gelina S. Kopeina   +3 more
doaj   +1 more source

Dissecting the Role of SAL1 in Metabolizing the Stress Signaling Molecule 3′-Phosphoadenosine 5′-Phosphate in Different Cell Compartments

Frontiers in Molecular Biosciences, 2022
Plants possess the most highly compartmentalized eukaryotic cells. To coordinate their intracellular functions, plastids and the mitochondria are dependent on the flow of information to and from the nuclei, known as retrograde and anterograde signals ...
Natallia Ashykhmina, Kai Xun Chan, Kai Xun Chan, Henning Frerigmann, Frank Van Breusegem, Frank Van Breusegem, Stanislav Kopriva, Ulf-Ingo Flügge, Tamara Gigolashvili   +8 more
doaj   +1 more source

The boundary of life and death: changes in mitochondrial and cytosolic proteomes associated with programmed cell death of Arabidopsis thaliana suspension culture cells

Frontiers in Plant Science, 2023
IntroductionDespite the critical role of programmed cell death (PCD) in plant development and defense responses, its regulation is not fully understood.
Johanna Schwarze, James C. Carolan, Gavin S. Stewart, Paul F. McCabe, Joanna Kacprzyk   +4 more
doaj   +1 more source