Results 201 to 210 of about 336,446 (348)

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Retraction: Eucommia ulmoides Cortex, Geniposide and Aucubin Regulate Lipotoxicity through the Inhibition of Lysosomal BAX. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant.

, 1989
W. Wayt Gibbs, Michael D. Schaber, T L Schofield, Edward M. Scolnick, Irving S. Sigal   +4 more
openalex   +2 more sources

The effect of hepatic stimulatory substance, isolated from regenerating hepatic cytosol, and 50,000 and 300,000 subfractions in enhancing survival in experimental acute hepatic failure in rats treated with D-galactosamine [PDF]

, 1986
A. Francavilla, Alfredo Di Leo, Lorenzo Polimeno, Judith S. Gavaler, R Pellicci, S Todo, Igal Kam, John Prelich, L Makowka, Thomas E. Starzl   +9 more
openalex   +1 more source

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

Correction: Salicylic acid biosynthesis in plants. [PDF]

Front Plant Sci
Lefevere H, Bauters L, Gheysen G.
europepmc   +1 more source

Cytochrome c is rapidly reduced in the cytosol after mitochondrial outer membrane permeabilization

, 2010
Maureen O. Ripple, Michelle Abajian, Roger Springett   +2 more
openalex   +2 more sources

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

Journal of Biological Chemistry, 1976
A. Poland, E. Glover, A. Kende
semanticscholar   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Origin of class B J-domain proteins involved in amyloid transactions. [PDF]

Proc Natl Acad Sci U S A
Domanski P, Stolarska M, Kalinowska K, Purzycki D, Schilke BA, Wyszkowski H, Pitek M, Szymanska A, Bury K, Czub J, Klosowska AA, Craig EA, Marszalek J, Tomiczek B.   +13 more
europepmc   +1 more source