Results 201 to 210 of about 453,295 (313)

Identification of microprotein-coding intronic polyadenylation isoforms and function in genotoxic anticancer drug response. [PDF]

Genome Biol
Devaux A, Tanaka I, Fouilleul Q, Heneman-Masurel A, Cadix M, Michallet S, Chakraborty A, Labbé CM, Fontrodona N, Sahoo S, Claude JB, Deloger M, Gestraud P, Tessier L, Mortada H, Lameiras S, Raynal V, Baulande S, Servant N, Auboeuf D, Eymin B, Vagner S, Dutertre M.   +22 more
europepmc   +1 more source

Purification and properties of a 3α-hydroxysteroid dehydrogenase of rat liver cytosol and its inhibition by anti-inflammatory drugs [PDF]

, 1984
T.M. Penning, I Mukharji, S Barrows, Paul Talalay   +3 more
openalex   +1 more source

Gigaxonin Potentiates Antiviral Innate Immune Responses by Targeting cGAS and TREX1

Advanced Science, EarlyView.
TREX1 antagonizes DNA sensor cGAS by degrading cytosolic DNA. This work identifies gigaxonin as a molecular switch that coordinates DNA sensing and clearance pathways to amplify antiviral responses. Under the steady state, gigaxonin maintains cellular homeostasis by mediating TREX1 ubiquitination and proteasomal degradation. During DNA virus infection,
Ben‐Zhe Ji, Jie Wang, Yi Tu, Shan Zhang, Yong‐Sheng Wei, Yan He, Bin Zhang, Qing‐Qing Zhao, Hao‐Min Hu, Yu Liu   +9 more
wiley   +1 more source

Identification of Chalcone Synthase Genes and Their Responses to Salt and Cold Stress in <i>Poncirus trifoliata</i>. [PDF]

Plants (Basel)
Jiang L, Sheng Y, Song C, Liu T, Sheng S, Xu X.   +5 more
europepmc   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

Botulinum neurotoxin Light Chain/A1 uses fast synaptic vesicle cycling to cleave plasma membrane bound SNAP-25. [PDF]

Commun Biol
Gardner A, Sneller M, Tepp WH, Barbieri JT, Pellett S.   +4 more
europepmc   +1 more source

Neutrophil elastase produces 52-kD and 30-kD glucocorticoid receptor fragments in the cytosol of human leukemia cells [PDF]

, 1987
CW Distelhorst, KE Janiga, KJ Howard, SE Strandjord, Campbell Ej   +4 more
openalex   +1 more source

PM2.5 Induce Endothelial‐Mesenchymal Transition and Cardiac Fibrosis via the NCOA4‐Mediated Ferritinophagy

Advanced Science, EarlyView.
This study primarily reveals that PM2.5‐derived Fe‐containing particles, particularly magnetite, are specifically enriched in the heart. Here, they interact with NCOA4 in endothelial cells, disrupt iron homeostasis by enhancing ferritinophagy, and subsequently trigger the process of EndMT through the NCOA4/KLF5 pathway.
Qinglin Sun, Mengyuan Wang, Lin Liu, Ruiyang Ding, Kanglin Yan, Shiqian Liu, Xiaoke Ren, Qing Xu, Zhiwei Sun, Qian Liu, Yi Yang, Junchao Duan   +11 more
wiley   +1 more source

Advancing Sustainable Agriculture: Molecular and Physiological Insights into Rapeseed Responsiveness to Organic Amendment Fertilization. [PDF]

Plants (Basel)
Picazo PJ, Ancín M, Gakière B, Gilard F, Soba D, Gámez AL, Houdusse D, Aranjuelo I.   +7 more
europepmc   +1 more source

Androphilic proteins in cytosols of human benign prostatic hypertrophy.

, 1977
TAKAOMI KODAMA, Seiko Honda, Jun Shimazaki   +2 more
openalex   +2 more sources